Search results for "DAS"
showing 10 items of 4164 documents
La Ley 41/2002, de 14 de noviembre, básica reguladora de la autonomia del paciente y de los derechos y obligaciones en materia de información y docum…
2003
En el presente trabajo se va a exponer (por su extensión en dos partes) el contenido básico de la reciente Ley sobre autonomía de los pacientes, con referencia expresa a las leyes autonómicas sobre la misma materia. Es de destacar que en todas ellas se consagra como un principio fundamental en la relación médico-paciente el principio de información y requerimiento del consentimiento al paciente para la realización de cualquier intervención sobre el mismo. Asimismo, se establecen los mecanismos de sustituciónde ese consentimiento cuando el paciente no se encuentre en condiciones de darlo por incapacidad o minoría de edad. Por otra parte, se regula mínimamente el documento de voluntades antic…
Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoG…
2019
This multicenter/multinational, open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat-dose avalglucosidase alfa (neoGAA), a second-generation, recombinant acid α-glucosidase replacement therapy, in late-onset Pompe disease (LOPD). Patients ≥18 years, alglucosidase alfa naïve (Naïve) or previously receiving alglucosidase alfa for ≥9 months (Switch), with baseline FVC ≥50% predicted and independently ambulatory, received every-other-week avalglucosidase alfa 5, 10, or 20 mg/kg over 24 weeks. 9/10 Naïve and 12/14 Switch patients completed the study. Avalglucosidase alfa was well-tolerated; no deaths…
Evaluation of yeasts from Ecuadorian chicha by their performance as starters for alcoholic fermentations in the food industry
2020
Yeasts involved in the spontaneous fermentation of traditional beverages like chicha (indigenous Andean beer) may have the potential to be used as starter cultures to improve the quality and microbiological safety of these products, but also as non-conventional alternatives to other food alcoholic fermentations. In this research, we isolated, identified and characterised yeast strains from four Ecuadorian chichas made by using four different raw materials: rice (RC), oat (OC), grape (GC) and a mixture of seven corn varieties (yamor, YC). Finally, 254 yeast isolates were obtained and identified by molecular methods. Eleven yeast genera and 16 yeast species were identified with relatively few…
El llano de inundación del Xúquer (País Valenciano): Geometría y repercusiones morfológicas y paisajísticas
1980
Ajudes públiques i SAE
2008
El autor analiza el problema de las ayudas publicas a los equipos de fútbol profesionales en relación con la prohibición impuesta por el derecho comunitario de subvencionar a las empresas para no falsear la competencia.
Ayudas y beneficiarios en la multa al Valencia
2017
En el articulo se razona el por qué es injusto que sea el Valencia CF el que deba de asumir en exclusiva el pago de la restitución que le exige la Comisión Europea por una ayuda ilegal dispensada por el Instituto Valenciano de Financias a una entidad para que ésta pudiera comprar un paquete accionarial en una ampliación de capital del propio Valencia. La ayuda se dispensó a la entidad que compró las acciones y sin embargo, ahora la comisión europea dice que el beneficiado es el Valencia CF porque gracias a ello se capitalizó. Los autores discuten esta decisión.
Venenos, cadáveres, excrementos
1999
Efficacy of the antioxidant ebselen in experimental uveitis.
1999
Inflammation results in the production of free radicals. In a model of experimental uveitis upon subcutaneous injection of endotoxin to Lewis rats, i.e., endotoxin-induced experimental uveitis (EIU), we have evaluated the status of the antioxidant capacity of ocular tissues. EIU results in a decrease of glutathione (GSH) content and glutathione peroxidase (GPx) activity in whole eye homogenates 24-h after endotoxin administration. Furthermore, an increase in malondialdehyde (MDA) content was observed in these same samples, thus confirming the involvement of oxidative stress in the pathophysiology of the process. In view of the ability of the antioxidant ebselen as GPx enzyme mimic, we teste…
Some aspects of cardiac antioxidant defence: Ebselen (PZ 51) treatment increases glutathione peroxidase activity in the rat heart
1990
Ebselcn (PZ 5 1 : 2-phenyl1.2-benzisoelenazol-3-( 2H)-one 1 is ii synthetic organoselenium compound with anti-inflammatory activity ( I . 21, which exhibits glutathione peroxidase (GSH-Px)-like activity, catalysing the reduction o f hydrogen peroxide as well as other organic peroxides [3-5]. Its antiinflammatory effect may be mediated by either the GSH-Px activity, the inhibition of leukotriene B4 formation [6], the antioxidant capacity, or a combination of all of them. Many attempts have been made to increase the antioxidant capacity of the myocardium, since free radical generation has been demonstrated in ischaemia-reperfusion damage [7, 81; superoxide dismutase (SOD) and catalase have be…
Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen.
2002
This study was aimed at examining the role of oxygen and nitrogen reactive species in a model of experimental uveitis upon intravitreal injection of bacterial endotoxin to albino New Zealand rabbits. The inflammatory response was evaluated in terms of: (i) the integrity of the blood aqueous barrier (protein and cell content in samples of aqueous humor), (ii) histopathological changes of the eyes, (iii) clinical evaluation (with a score index based on clinical symptoms), and (iv) the concentration of malondialdehyde (MDA), in aqueous humor, as a marker of oxidative stress. Betamethasone was used as reference treatment, superoxide dismutase as quencher of superoxide anion, L-N(G)-nitro-L-argi…