Search results for "DAT"
showing 8 items of 28078 documents
Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry
2021
The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiological (e.g., signaling) and pathological (e.g., oxidative stress) states. This PTM typically maps at multiple protein sites, generating a heterogeneous population of proteoforms with specific biophysical and biochemical properties. The identification and quantitation of the variety of oxidized proteoforms originated under a given condition is required to assess the exact molecular nature of the species responsible for the process under investigation…
Atklāts, krustota dizaina ultra-ilgstošas darbības β2-agonista olodaterola un īsas darbības β2-agonista salbutamola bronhodilatējošas ietekmes ātruma…
2018
Astmai un hroniskai obstruktīvai plaušu slimībai (HOPS) ir liela socio-ekonomiska ietekme uz sabiedrīebu un tās ir vienas no galvenajiem saslimstības un mirstības cēloņiem pasaulē. Šo obstruktīvo plaušu slimību ārstēšana balstās uz β2-agonistu un citu zāļu bronhodilatatora iedarbību. Lai salīdzinātu ilgstošas-darbības β2-agonista olodaterola bronhodilatācijas efektu ar īslaicīgas-darbības β2-agonistu salbutamolu tika veikts atklāto pārbaužu eksperimentāls pētījums, kurā piedalījās 10 pacienti ar HOPS vai astmu, un tika noteikts abu zāļu bronhodilatācijas efekts, izmantojot FEV1 kā galveno parametru. Tika veikti ķermeņa plejismogrāfijas izmeklējumi, kuru laikā nolasīja sākumpunkta vērtību. 5…
High-precision measurement of a low Q value for allowed β−-decay of 131I related to neutrino mass determination
2022
The ground-state-to-ground-state β−-decay 131I (7/2+) → 131Xe (3/2+) Q value was determined with high precision utilizing the double Penning trap mass spectrometer JYFLTRAP at the IGISOL facility. The Q value of this β−-decay was found to be Q = 972.25(19) keV through a cyclotron frequency ratio measurement with a relative precision of 1.6 × 10−9. This was realized using the phase-imaging ion-cyclotron-resonance technique. The new Q value is more than 3 times more precise and 2.3σ higher (1.45 keV) than the value extracted from the Atomic Mass Evaluation 2020. Our measurement confirms that the β−-decay to the 9/2+ excited state at 971.22(13) keV in 131Xe is energetically allowed with a Q va…
On the Amount of Nonconstructivity in Learning Recursive Functions
2011
Nonconstructive proofs are a powerful mechanism in mathematics. Furthermore, nonconstructive computations by various types of machines and automata have been considered by e.g., Karp and Lipton [17] and Freivalds [11]. They allow to regard more complicated algorithms from the viewpoint of much more primitive computational devices. The amount of nonconstructivity is a quantitative characterization of the distance between types of computational devices with respect to solving a specific problem. In the present paper, the amount of nonconstructivity in learning of recursive functions is studied. Different learning types are compared with respect to the amount of nonconstructivity needed to lea…
Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period
2016
This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resol…
Взаимодействие автоматизированных систем управления
1989
Сборник научных трудов посвящен теоретическим и практическим проблемам создания интегрированной системы обработки данных агро-промышленного комплекса. В сборнике гредставлены результаты исследований по проблемам методического, информационного, программного и технического обеспечения интегрированной системы обработки данных.
Cilvēka kustību novērošana, izmantojot inerciālos sensorus
2020
Cilvēka kustību novērošana, izmantojot inerciālos sensorus, mūsdienas ir ļoti populāra pētniecības metode, ko pielieto medicīnā, rehabilitācijā, sportā un citās nozarēs. Darbā tika izpētītas tehnoloģiskās iespējas, lai veiktu cilvēka kustību novērošanu, kā arī esošie pielietojumi cilvēka kustību novērošanai hokejā. Darba mērķis ir veikt profesionāla un entuziasta līmeņa hokejistu hokeja metienu kustību novērošanu, lai noteiktu, kura entuziasta hokeja metiens procentuāli visvairāk atbilst profesionāla hokeja metiena sasniegtajam lineārajām paātrinājumam. Novēroto datu apstrādei, tika izmantota “Python” programmēšanas valoda, ar kuru tika …
High frequency data entry: statistical findings at high frequency
2010
We introduce some of the most common types of high-frequency financial data: tick-by-tick data, trade andquote data, order bookdata, andmarket member data. We describe the types of variables that are usually available in the most popular high-frequency financial databases. We discuss the issues related to the handling of these data, including cleaning protocols, timing issues, and issues related to data size. We then briefly consider the issues related to the stylized facts detected in the empirical analysis of high- frequency data. Specifically, we consider (i) the irregular temporal spacing of the events at high frequency and its relevance for the econometric modeling of financial variables, (…