Search results for "DDE"

Genetic parameters for somatic cell score according to udder infection status in Valle del Belice dairy sheep and impact of imperfect diagnosis of in…

2010

Abstract Background Somatic cell score (SCS) has been promoted as a selection criterion to improve mastitis resistance. However, SCS from healthy and infected animals may be considered as separate traits. Moreover, imperfect sensitivity and specificity could influence animals' classification and impact on estimated variance components. This study was aimed at: (1) estimating the heritability of bacteria negative SCS, bacteria positive SCS, and infection status, (2) estimating phenotypic and genetic correlations between bacteria negative and bacteria positive SCS, and the genetic correlation between bacteria negative SCS and infection status, and (3) evaluating the impact of imperfect diagno…

Visceral fat area as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with antiangiogenic age…

2011

Abstract Purpose. A better identification of patients who are more likely to benefit from vascular endothelial growth factor–targeted therapy is warranted in metastatic renal cell carcinoma (mRCC). As adipose tissue releases angiogenic factors, we determined whether parameters such as visceral fat area (VFA) were associated with outcome in these patients. Experimental Design. In 113 patients with mRCC who received antiangiogenic agents (bevacizumab, sunitinib, or sorafenib) (n = 64) or cytokines (n = 49) as first-line treatment, we used computed tomography to measure VFA and subcutaneous fat area (SFA). We evaluated associations linking body mass index (BMI), SFA, and VFA to time to progres…

What links BRAF to the heart function? new insights from the cardiotoxicity of BRAF inhibitors in cancer treatment

2015

The RAS-related signalling cascade has a fundamental role in cell. It activates differentiation and survival. It is particularly important one of its molecules, B-RAF. B-RAF has been a central point for research, especially in melanoma. Indeed, it lacked effective therapeutic weapons since the early years of its study. Molecules targeting B-RAF have been developed. Nowadays, two classes of molecules are approved by FDA. Multi-target molecules, such as Sorafenib and Regorafenib, and selective molecules, such as Vemurafenib and Dabrafenib. Many other molecules are still under investigation. Most of them are studied in phase 1 trials. Clinical studies correlate B-RAF inhibitors and QT prolonga…

An Agile methodology for Manufacturing Control Systems development

2007

Robotized manufacturing cells are required more and more often to process high variety of short life-cycle product. This increases the need for methods and techniques for easy reconfiguration of software programs running in Programmable Logic Controllers (PLC), i.e., devices able to control manufacturing systems. PLCs run embedded code characterized by a procedural nature that does not make it quite reconfigurable. In this paper we propose an AGIle COntrol System Development (AGICOSD) methodology that uses various practices of Agile software development methodologies and the Design By Contract (DBC) practice for modeling and programming manufacturing control systems. In this context we prop…

Development of the BCI Device Controlling C++ Software, Based on Existing Open Source Projects

2021

The possibility of using the BCI open source code for building BCI controlled device, based on small AVR or ARM microcontrollers was considered. Some techniques to extract code snippets from other BCI projects were presented in the case of OpenViBE as the code donor. Problem with obtaining driver source codes for factory BCI devices has been pointed out.

Usage of HMM-Based Speech Recognition Methods for Automated Determination of a Similarity Level Between Languages

2019

The problem of automated determination of language similarity (or even defining of a distance on the space of languages) could be solved in different ways – working with phonetic transcriptions, with speech recordings or both of them. For the recordings, we propose and test a HMM-based one: in the first part of our article we successfully try language detection, afterwards we are trying to calculate distances between HMM-based models, using different metrics and divergences. The Kullback-Leibler divergence is the only one we got good results with – it means that the calculated distances between languages correspond to analytical understanding of similarity between them. Even if it does not …

Intravesical gemcitabine in superficial bladder tumors. Results of a phase I-II study

2004

the good tolerability of intravesical gemcitabine have been recently published. The evaluation of the activity on a papillary marker lesion is the best tool to measure the efficacy of a drug by intravesical route against superficial transitional cell carcinoma of the bladder (TCCB). The scientific background and the ethical acceptability of this approach have been validated by the European Organization for Research and Treatment of Cancer Urological Group. The aim of the present study was to evaluate the ablative efficacy of weekly intravesical instillations of gemcitabine against a histologically proven papillary marker lesion. MATERIAL & METHODS: Twenty-seven patients, affected by recurre…

FPGA implementation of Spiking Neural Networks supported by a Software Design Environment

2011

Abstract This paper is focused on the creation of Spiking Neural Networks (SNN) in hardware due to their advantages for certain problem solving and their similarity to biological neural system. One of the main uses of this neural structure is pattern classification. The chosen model for the spiking neuron is the Spike Response Model (SRM). For SNN design and implementation, a software application has been developed to provide easy creation, simulation and automatic generation of the hardware model. VHDL was used for the hardware model. This paper describes the functionality of SNN and the design procedure followed to obtain a working neural system in both software and hardware. Designed VHD…

Progressive Isolated Hypoglossal Nerve Palsy and Sudden Asphyzial Death

2008

The pathology of bladder cancer: An update on selected issues

2006

OBJECTIVE: To achieve a closer relationship between urologists and pathologists and to use a common language and identical objectives in the pathology of bladder cancer. METHODS AND RESULTS: Special emphasis was given to an analysis of the new World Health Organization (WHO) grading system, to the interpretation of the last Tumour-Nodes-Metastasis staging rules, and to identifying new markers of prognostic significance in clinical practice. A consensus was achieved on the main points. CONCLUSIONS: The 2004 WHO grading system must become acceptable to clinicians, perhaps by a minimal modification of the present terminology. Simple transurethral resection-biopsy should be expressed in terms o…