Search results for "DDE"
showing 10 items of 1858 documents
Diet-Induced Metabolic Syndrome Reduced Heart Rate Variability and Increased Irregularity and Complexity of Short-Term RR Time Series in Rabbits.
2019
Simple Summary In recent years, obesity and metabolic syndrome (MetS) have become more prevalent, owing to increased unhealthy habits and sedentary lifestyles becoming public health problems. Both conditions are linked with a higher prevalence of sudden cardiac death (SCD), but the exact mechanisms are not known. An autonomic nervous system imbalance can produce atrial and ventricular arrhythmias, which cause SCD, and this can be quantified by analyzing heart rate variability (HRV). We investigated HRV using time-domain, frequency-domain and nonlinear analyses during the development of MetS in rabbits and found HRV modifications that could be associated with the higher prevalence of SCD in …
Intravesical chemotherapy for intermediate risk non-muscle invasive bladder cancer recurring after a first cycle of intravesical adjuvant therapy
2015
Context: The therapeutic strategy in intermediate risk (IR) non-muscle invasive bladder cancer (NMIBC) recurring after intravesical therapy (IT) is not well defined. Most patients are usually retreated by Bacillus Calmette-Guerin (BCG). Aims: To evaluate the efficacy of intravesical chemotherapy (ICH) given at recurrence after the first cycle of ICH in IR-NMIBC recurring 6 months or later. Settings and Design: Retrospective analysis of the efficacy of ICH given after previous IT. Materials and Methods: The clinical files of IR-NMIBC patients recurring later than 6 months after transurethral resection (TUR) and IT and retreated by IT were reviewed. The patients should be at intermediate risk…
An Anti-Ubiquitin Antibody Response in Transitional Cell Carcinoma of the Urinary Bladder
2015
BackgroundTo use combinatorial epitope mapping ("fingerprinting") of the antibody response to identify targets of the humoral immune response in patients with transitional cell carcinoma (TCC) of the bladder.MethodsA combinatorial random peptide library was screened on the circulating pool of immunoglobulins purified from an index patient with a high risk TCC (pTa high grade plus carcinoma in situ) to identify corresponding target antigens. A patient cohort was investigated for antibody titers against ubiquitin.ResultsWe selected, isolated, and validated an immunogenic peptide motif from ubiquitin as a dominant epitope of the humoral response. Patients with TCC had significantly higher anti…
Kinezjologia w edukacji dziecka
2014
IL PAGAMENTO “NECESSARIAMENTE INTERMEDIATO” DELL’OBBLIGAZIONE PECUNIARIA NELLA LEGISLAZIONE DI DERIVAZIONE EUROPEA: VERSO IL SUPERAMENTO DELL’UNICITÀ…
2015
Il lavoro muove dall’idea di analizzare il sistema delle regole che definiscono, sul piano dell’an, del quando e del quomodo, l’esattezza dell’adempimento che può definirsi (necessariamente) intermediato dell’obbligazione pecuniaria: nella vicenda solutoria della quale, cioè, risulti indefettibile, per volontà della legge o per scelta dei privati, l’interposizione di uno o più soggetti, altri rispetto al debitore e al creditore parti originarie del rapporto obbligatorio, con funzioni ausiliarie. Ciò al fine di saggiare la bontà della ipotesi ricostruttiva in base alla quale l’adempimento dell’obbligazione pecuniaria per mezzo di operazioni di pagamento intermediato non sia governato dalla l…
Zespół przerostu bakteryjnego jelita cienkiego
2021
Zespół przerostu bakteryjnego jelita cienkiego (SIBO) jest heterogennym zespołem charakteryzującym się wzrostem liczby i/lub obecnością nietypowych bakterii w jelicie cienkim. Na złożoną etiologię SIBO składają się zaburzenia ochronnych mechanizmów przeciwbakteryjnych jak zmniejszona kwaśność soku żołądkowego, zewnątrzwydzielnicza niewydolność trzustki, zespoły niedoboru odporności oraz nieprawidłowości anatomiczne jak niedrożność jelita cienkiego, uchyłki, przetoki, hirurgiczna ślepa pętla, wcześniejsze resekcje krętniczo-kątnicze oraz zaburzenia ruchliwości. Objawy kliniczne SIBO mogą być niespecyficzne. Najczęściej występuje niestrawność, biegunka, wzdęcia, dyskomfort w jamie brzusznej. …
Model selection procedure for mixture hidden Markov models
2021
This paper proposes a model selection procedure to identify the number of clusters and hidden states in discrete Mixture Hidden Markov models (MHMMs). The model selection is based on a step-wise approach that uses, as score, information criteria and an entropy criterion. By means of a simulation study, we show that our procedure performs better than classical model selection methods in identifying the correct number of clusters and hidden states or an approximation of them
Clickstream Data Analysis: A Clustering Approach Based on Mixture Hidden Markov Models
2023
Nowadays, the availability of devices such as laptops and cell phones enables one to browse the web at any time and place. As a consequence, a company needs to have a website so as to maintain or increase customer loyalty and reach potential new customers. Besides, acting as a virtual point-of-sale, the company portal allows it to obtain insights on potential customers through clickstream data, web generated data that track users accesses and activities in websites. However, these data are not easy to handle as they are complex, unstructured and limited by lack of clear information about user intentions and goals. Clickstream data analysis is a suitable tool for managing the complexity of t…
«The Uneasy Modernist: John Middelton Murry »
2014
International audience; This presentation discusses John Middleton Murry "The Trajectory of an Intellectual" (1919)