Search results for "DECIPHER"
showing 10 items of 11 documents
The search for novel targets in Alzheimer's disease—The 90s redux
2021
Alzheimer's disease (AD) is a complex disease of the brain. Despite over 100 years of basic and clinical research, significantly intensified in the last three decades, the exact cause of this neurodegeneration is still an enigma. Based on neuroanatomical, experimental, and clinical findings, a series of hypotheses on AD pathogenesis have evolved. Among them, the "amyloid cascade hypothesis" has been most prominent. Clinical efforts targeting the biochemistry of amyloid β-protein (Aβ) as causal therapy have all failed so far, which may mean that the pathogenic mechanism of AD is less straightforward than initially thought. While there was good scientific reason to support this hypothesis bef…
High-Throughput Mapping of 2′-O-Me Residues in RNA Using Next-Generation Sequencing (Illumina RiboMethSeq Protocol)
2017
Detection of RNA modifications in native RNAs is a tedious and laborious task, since the global level of these residues is low and most of the suitable physico-chemical methods require purification of the RNA of interest almost to homogeneity. To overcome these limitations, methods based on RT-driven primer extension have been developed and successfully used, sometimes in combination with a specific chemical treatment. Nowadays, some of these approaches have been coupled to high-throughput sequencing technologies, allowing the access to transcriptome-wide data. RNA 2'-O-methylation is one of the ubiquitous nucleotide modifications found in many RNA types from bacteria, archaea, and eukarya.…
A Generalization of Girod’s Bidirectional Decoding Method to Codes with a Finite Deciphering Delay
2012
In this paper we generalize an encoding method due to Girod (cf. [6]) using prefix codes, that allows a bidirectional decoding of the encoded messages. In particular we generalize it to any finite alphabet A, to any operation defined on A, to any code with finite deciphering delay and to any key x ∈ A+ , on a length depending on the deciphering delay. We moreover define, as in [4], a deterministic transducer for such generalized method. We prove that, fixed a code X ∈ A* with finite deciphering delay and a key x ∈ A *, the transducers associated to different operations are isomorphic as unlabelled graphs. We also prove that, for a fixed code X with finite deciphering delay, transducers asso…
Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency
2020
International audience; PURPOSE: Lamb-Shaffer syndrome (LAMSHF) is a neurodevelopmental disorder described in just over two dozen patients with heterozygous genetic alterations involving SOX5, a gene encoding a transcription factor regulating cell fate and differentiation in neurogenesis and other discrete developmental processes. The genetic alterations described so far are mainly microdeletions. The present study was aimed at increasing our understanding of LAMSHF, its clinical and genetic spectrum, and the pathophysiological mechanisms involved.METHODS: Clinical and genetic data were collected through GeneMatcher and clinical or genetic networks for 41 novel patients harboring various ty…
CODING PARTITIONS OF REGULAR SETS
2009
A coding partition of a set of words partitions this set into classes such that whenever a sequence, of minimal length, has two distinct factorizations, the words of these factorizations belong to the same class. The canonical coding partition is the finest coding partition that partitions the set of words in at most one unambiguous class and other classes that localize the ambiguities in the factorizations of finite sequences. We prove that the canonical coding partition of a regular set contains a finite number of regular classes and we give an algorithm for computing this partition. From this we derive a canonical decomposition of a regular monoid into a free product of finitely many re…
Automated facies identification by Direct Push-based sensing methods (CPT, HPT) and multivariate linear discriminant analysis to decipher geomorpholo…
2021
In ad 1362, a major storm surge drowned wide areas of cultivated medieval marshland along the north‐western coast of Germany and turned them into tidal flats. This study presents a new methodological approach for the reconstruction of changing coastal landscapes developed from a study site in the Wadden Sea of North Frisia. Initially, we deciphered long‐term as well as event‐related short‐term geomorphological changes, using a geoscientific standard approach of vibracoring, analyses of sedimentary, geochemical and microfaunal palaeoenvironmental parameters and radiocarbon dating. In a next step, Direct Push (DP)‐based Cone Penetration Testing (CPT) and the Hydraulic Profiling Tool (HPT) wer…
Neutron tomography of ancient lead artefacts
2014
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. The investigations presented here show the results of an epigraphic analysis on ancient Roman lead ingots rescued from shipwrecks along the coast of Sicily (Italy) by means of Neutron Tomography (NT). The artefacts, including a lead horn, can be dated back to a period between the 3rd and 1st century BC. The three dimensional NT reconstructions helped the decipherment of hidden s…
Exotic Models May Offer Unique Opportunities to Decipher Specific Scientific Question: The Case ofXenopusOlfactory System
2013
The fact that olfactory systems are highly conserved in all animal species from insects to mammals allow the generalization of findings from one species to another. Most of our knowledge about the anatomy and physiology of the olfactory system comes from data obtained in a very limited number of biological models such as rodents, Zebrafish, Drosophila, and a worm, Caenorhabditis elegans. These models have proved useful to answer most questions in the field of olfaction, and thus concentrating on these few models appear to be a pragmatic strategy. However, the diversity of the organization and physiology of the olfactory system amongst phyla appear to be greater than generally assumed and th…
The Power of Literature to Decipher the Archetype of Lone-Wolf
2021
The Soviet Union collapse marked the end of the Cold War and the rise of the US as the only superpower, at least until 9/11, a foundational event where four civil aeroplanes were directed against the commercial and military hallmarks of the most powerful nation. Terrorism and the so-called War on Terror characterized the turn of a bloody century whose legacy remains to date. The chapter explores the dilemmas of lone-wolf terrorism from the lens of literature as well as cultural theory. The authors hold the thesis that terrorism activates some long-dormant narrative forged in the colonial period respecting to the “non-Western other.” Having said this, the chapter dissects the plot of some no…
A Generalization of Girod's Bidirectional Decoding Method to Codes with a Finite Deciphering Delay
2012
Girod’s encoding method has been introduced in order to efficiently decode from both directions messages encoded by using finite prefix codes. In the present paper, we generalize this method to finite codes with a finite deciphering delay. In particular, we show that our decoding algorithm can be realized by a deterministic finite transducer. We also investigate some properties of the underlying unlabeled graph.