Search results for "DECLINE"
showing 10 items of 261 documents
RETA A TU MENTE, DESAFÍA A TU CEREBRO: COMPLEJIDAD AMBIENTAL Y SALUD CEREBRAL
2016
Abstract.According to the World Health Organization, it is estimated that more than 30 million people suffer from Alzheimer’s disease in the world. Currently, there is great interest in developing strategies to counteract the cognitive decline that accompanies aging and, to a greater extent, neurodegenerative diseases. The aim of the current study is to analyze the experimental evidence supporting the hypothesis that interventions based on novelty and complexity are more effective in order to achieve successful aging. In animal models it has shown that enriched environments and performing voluntary exercise can improve performance in learning and memory tasks, decrease anxiety response and …
Differential evolution of PSA-NCAM expression during aging of the rat telencephalon
2007
Changes in the ability of neuronal networks to undergo structural remodeling may be involved in the age-associated cognitive decline. The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) declines dramatically during postnatal development, but persists in several regions of the young-adult rat telencephalon, where it participates, through its anti-adhesive properties, in neuronal structural plasticity. However, PSA-NCAM expression during aging has only been studied in the dentate gyrus and the piriform cortex layer II, where it is strongly downregulated in adult (middle-aged) individuals. Using immunohistochemistry, we have observed that in most of the telencephalic areas …
Association of basal forebrain volumes and cognition in normal aging.
2013
The basal forebrain cholinergic system (BFCS) is known to undergo moderate neurodegenerative alterations during normal aging and severe atrophy in Alzheimer's disease (AD). It has been suggested that functional and structural alterations of the BFCS mediate cognitive performance in normal aging and AD. But, it is still unclear to what extend age-associated cognitive decline can be related to BFCS in normal aging. We analyzed the relationship between BFCS volume and cognition using MRI and a comprehensive neuropsychological test battery in a cohort of 43 healthy elderly subjects spanning the age range from 60 to 85 years. Most notably, we found significant associations between general intell…
L’IPOTIROIDISMO NELLE PERSONE ANZIANE: IMPORTANZA DI UNA ADEGUATA TERAPIA SOSTITUTIVA ORMONALE
2013
La prevalenza dei disturbi della ghiandola tiroidea aumenta con l’età, soprattutto nelle donne. L’ipofunzione tiroidea conclamata in età avanzata può manifestarsi clinicamente con sintomi e segni simili alle modificazioni che normalmente accompagnano l’invecchiamento o come disturbi di altri organi. Per tale motivo, un alto indice di sospetto è essenziale per rilevare l’ipotiroidismo in anziani con comorbilità multiple, alterazioni nutrizionali e/o polifarmacoterapia. La decisione di iniziare una terapia sostitutiva ormonale nell’ipotiroidismo conclamato non è discutibile. Viceversa, esiste ancora controversia sulla decisione di trattare o non trattare l’ipotiroidismo subclinico; le raccoma…
Urban structure changes and environmental factors of Valencian Community towns as potentital drivers of the House Sparrow decline
2021
El gorrión común Passer domesticus (Linnaeus, 1758) se encuentra en declive en gran parte de Europa. En España, destaca el caso de la Comunidad Valenciana, área de estudio de esta tesis, con descensos superiores al 95% en zonas rurales y al 70% en zonas urbanas. Las causas del declive en zonas urbanas no son claras. En los pueblos y ciudades de la Comunidad Valenciana se están produciendo importantes procesos de transformación de la estructura urbana que afectan a la disponibilidad y adecuación del hábitat para la especie. El objetivo de la tesis fue explorar esos cambios como potenciales impulsores del declive del gorrión común. La tesis se distribuye en 8 capítulos. El capítulo 1 contiene…
Prevention of Functional Decline by Reframing the Role of Nursing Homes?
2017
Institutionalization is generally a consequence of functional decline driven by physical limitations, cognitive impairments, and/or loss of social supports. At this stage, intervention to reverse functional losses is often too late. To be more effective, geriatric medicine must evolve to intervene at an earlier stage of the disability process. Could nursing homes (NHs) transform from settings in which many residents dwell to settings in which the NH residents and those living in neighboring communities benefit from staff expertise to enhance quality of life and maintain or slow functional decline? A task force of clinical researchers met in Toulouse on December 2, 2015, to address some of t…
Giustizia ambientale e recupero delle aree verdi: il caso di Palermo
2021
L’urban shrinkage è diventata una questione centrale tanto nel dibattito scientifico quanto nell’agenda politica di diverse città europee. Secondo i dati EUROSTAT (2019), circa il 40% delle città europee con più di 200.000 abitanti stanno perdendo popolazione; una contrazione che si esplicita maggiormente, sotto il profilo spaziale, in una progressiva sottoutilizzazione del patrimonio edificato, così come nel contestuale incremento di aree e terreni in stato di abbandono. In questo quadro controverso di mutazione strutturale della città, così come l’abbiamo conosciuta, le politiche urbane alla prova in Europa tentano di declinare la decrescita quale occasione strategica di investimento sull…
A new paradox of the digital economy - Structural sources of the limitation of GDP statistics
2018
The Internet has dramatically changed the way we conduct business and our daily lives by provided us with unprecedented services and conveniences. However, contrary to such accomplishments, productivity in industrialized countries is now experiences an apparent decline. This has raised the question of a possible productivity paradox in the digital economy. The limitation of GDP statistics in measuring the advancement of the digital economy has thus become an important subject. This paper analyzed the structural sources of this problem. Utilizing the results of empirical analyses of national, industrial, and individual behavior in the digital economy, solutions to these critical issues were …
Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-…
2021
Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18–60 years at baseline (female 51%), BMI and the ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) as well as forced mid-expiratory flow (FEF25–75%) were measured three times over 20 follow-up years. The causal effects of BMI in childhood and adulthood on FEV1/FVC and FEF25–75% were assessed in predictive (BMI averaged over 1st and 2nd, lung function (LF) averaged over 2nd and 3rd fol…
Spatial Bayesian Modeling Applied to the Surveys of Xylella fastidiosa in Alicante (Spain) and Apulia (Italy)
2020
The plant-pathogenic bacterium Xylella fastidiosa was first reported in Europe in 2013, in the province of Lecce, Italy, where extensive areas were affected by the olive quick decline syndrome, caused by the subsp. pauca. In Alicante, Spain, almond leaf scorch, caused by X. fastidiosa subsp. multiplex, was detected in 2017. The effects of climatic and spatial factors on the geographic distribution of X. fastidiosa in these two infested regions in Europe were studied. The presence/absence data of X. fastidiosa in the official surveys were analyzed using Bayesian hierarchical models through the integrated nested Laplace approximation (INLA) methodology. Climatic covariates were obtained from …