Search results for "DECLINE"
showing 10 items of 261 documents
Metformin Use and Cognitive Function in Older Adults With Type 2 Diabetes Following a Mediterranean Diet Intervention
2021
Background and Purpose: Both adherence to the Mediterranean diet (MedDiet) and the use of metformin could benefit the cognitive performance of individuals with type 2 diabetes, but evidence is still controversial. We examined the association between metformin use and cognition in older adults with type 2 diabetes following a MedDiet intervention. Methods: Prospective cohort study framed in the PREDIMED-Plus-Cognition sub-study. The PREDIMED-Plus clinical trial aims to compare the cardiovascular effect of two MedDiet interventions, with and without energy restriction, in individuals with overweight/obesity and metabolic syndrome. The present sub-study included 487 cognitively normal subjects…
Arthrinium phaeospermum , Phoma cladoniicola and Ulocladium consortiale , New Olive Pathogens in Italy
2013
In recent years, leaf necrosis and twig dieback in the olive crop have been detected in Sicily (Italy). In this article, we identify the predominant fungal species associated with symptomatic leaves and twigs, using morphological features and DNA sequencing of the internal transcribed spacer (ITS) region, as Alternaria alternata, Arthrinium phaeospermum, Phoma cladoniicola and Ulocladium consortiale. The pathogenicity of these four species was tested on olive plants cv. Biancolilla. All species were pathogenic on leaves, but only U. consortiale produced cortical lesions on twigs, thus suggesting its main role in the Olea europaea twig dieback. To our knowledge, this is the first report of A…
Reflections on the questionnaire at the workshops: Methodology for assessing the campus sustainability from the perspective of multi-level antifragil…
2017
Aim: The author provides a critical reflection of the questionnaire discussed at the workshop “Methodology for assessing the campus sustainability from the perspective of multi-level antifragility” held on Friday 13 May 2016 at the WSB University in Wrocław. The aim is to make a general diagnosis of the current situation in higher education in Poland, and to propose a direction of change than can enable its survival and improve its quality. Design / Research methods: In the article, the author gives his personal reflections regarding the research questionnaire discussed at the workshop “Methodology for assessing the campus sustainability from the perspective of multi-level antifragility” in…
The Role of Human Microbiota in Myasthenia Gravis: A Narrative Review
2023
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fluctuating weakness of the skeletal muscles. Although antibodies against the neuromuscular junction components are recognized, the MG pathogenesis remains unclear, even if with a well-known multifactorial character. However, the perturbations of human microbiota have been recently suggested to contribute to MG pathogenesis and clinical course. Accordingly, some products derived from commensal flora have been demonstrated to have anti-inflammatory effects, while other have been shown to possess pro-inflammatory properties. In addition, patients with MG when compared with age-matched controls showed a distinctive …
The effect of obesity combined with low muscle strengthon decline in mobility in older persons - Results from the InCHIANTI Study
2009
Objective: Both obesity and muscle impairment are increasingly prevalent among older persons and negatively affect health and physical functioning. However, the combined effect of coexisting obesity and muscle impairment on physical function decline has been little studied. We examined whether obese persons with low muscle strength experience significantly greater declines in walking speed and mobility than persons with only obesity or low muscle strength. Design: Community-dwelling adults aged ⩾65 years (n=930) living in the Chianti geographic area (Tuscany, Italy) were followed for 6 years in the population-based InCHIANTI study. Measurements: On the basis of baseline measurements (1998–2…
Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young
2021
Metabolic syndrome (MetS) is a known risk factor for cognitive decline. Using polygenic rat models selectively bred for high and low intrinsic exercise capacity and simultaneously modelling as low and high innate risk factor for MetS respectively, we have previously shown that adult animals with lower exercise capacity/higher MetS risk perform poorly in tasks requiring flexible cognition. However, it is not known whether these deficits in cognition are present already at young age. Also, it is unclear whether the high risk genome is related also to lower-level cognition, such as sensory gating measured as prepulse inhibition. In this study, young and adult (5-8 weeks and ∼9 months) rats sel…
Executive function and life-space mobility in old age
2018
Life-space assessment incorporates all movements in terms of the distance from home, the frequency of movement and the need of assistance for movement. Executive function (EF) is an important higher order cognitive ability that controls and guides people’s goal-directed actions. We examined the cross-sectional and longitudinal associations between EF and life-space mobility, and investigated if perceived walking difficulties, lower extremity performance, and transportation difficulties explain the association. Methods 157 community-dwelling persons aged 76–91 years participated in the study at the baseline, and 103 of them in 2-year follow-up study. Based on the distribution on the Trail Ma…
Implications of fisheries‐induced evolution for population recovery: Refocusing the science and refining its communication
2019
The argument that sufficiently high fishing mortality (selective or not) can effect genetic change in fished populations has gained considerable traction since the late 1970s. The intervening decades have provided compelling experimental and model‐based evidence that fisheries‐induced evolution (FIE) can cause genetic changes in life history, behaviour and body shape, given sufficiently high trait heritability, selection intensity and time. Fisheries‐induced evolution research has also identified or inferred negative implications to population recovery and sustainable yield, prompting calls for evolutionarily enlightened management to reduce the probability of FIE and mitigate its risks. Su…
Sequestrati dalla vendetta: “rimanere chiusi fuori dall’oggetto”
2013
RiassuntoA partire dal loro lavoro di psicoterapeute e attraverso alcuni frammenti clinici che si riferiscono ad un gruppo di adolescenti svoltosi in un quartiere a rischio di Palermo, le Autrici analizzano la dimensione mafiosa non restringendola al solo comportamento criminale; piuttosto declinandola lungo alcuni significanti: non identità e gruppo mafioso che colonizza e sottomette lo psichismo del singolo; fantasmi familiari potenti e spietati che impediscono il costituirsi di sé originali e autonomi; personalità impastate di indifferenza emotiva e vendicatività. Significanti che rendono conto delle vaste aree di desertificazione e pietrificazione – resistenza al cambiamento – avvertita…
Effect Declines Are Systematic, Strong, and Ubiquitous: A Meta-Meta-Analysis of the Decline Effect in Intelligence Research
2019
Empirical sciences in general and psychological science in particular are plagued by replicability problems and biased published effect sizes. Although dissemination bias-related phenomena such as publication bias, time-lag bias, or visibility bias are well-known and have been intensively studied, another variant of effect distorting mechanisms, so-called decline effects, have not. Conceptually, decline effects are rooted in low initial (exploratory) study power due to strategic researcher behavior and can be expected to yield overproportional effect declines. Although decline effects have been documented in individual meta-analytic investigations, systematic evidence for decline effects in…