Search results for "DECORIN"

showing 4 items of 14 documents

Anti-oncogenic role of decorin: identification of new markers.

2009

Settore BIO/18 - Geneticadecorin breast cancerSettore BIO/06 - Anatomia Comparata E Citologia
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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Decorin Expression and Oncosuppression in Human Embryonic Carcinomas

2019

Human embryonic stem cells in culture can transform into malignant, cancer-like cells exhibiting lesser differentiation. After transplantation, these transformed cells can form highly malignant germ cell tumors. In humans, germ cell tumors often appear at gonadal sites, like in the testis. In this study, we examined the expression of small leucine rich proteoglycans in normal and karyotypically abnormal human embryonic stem cells using a publicly available transcriptome data. We also examined the expression of the small leucine rich proteoglycans in healthy human testis and in different human testicular non-seminoma germ cell tumors using IST Online database. Furthermore, we localized the e…

embryonal carcinomaendocrine systemDecorinCellular differentiationEmbryonal carcinomamedicinesoluväliaineteratomaproteoglycanbiologyGeneral Medicinemedicine.diseaseEmbryonic stem cellkantasolutkarsinoomatCell biologycarbohydrates (lipids)stem cellmedicine.anatomical_structuresyöpäsolutProteoglycanbiology.proteinGerm cell tumorsin situ hybridizationproteiinitStem cellGerm cell
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Developmental expression of human cartilage matrix protein.

1994

Cartilage matrix protein (CMP) is a non-collagenous component of cartilage with a yet unknown function. In this study we used in situ hybridization to investigate the temporal and sptial distribution of CMP transcripts during human embryonic and early fetal development, and compared it to the pattern of expression observed for collagen types I, II, X, and decorin. The distribution of CMP and collagen type II transcripts followed a similar pattern in the embryonic bone anlage, the fetal growth plate, and the developing vertebral column. Expression was highest in the upper hypertrophic and lower proliferative zone, whereas calcified cartilage was negative throughout the different stages of bo…

medicine.medical_specialtyTranscription GeneticDecorinBiologyMatrix (biology)Cartilage Oligomeric Matrix ProteinKidneyChondrocyteBone and BonesExtracellular matrixEmbryonic and Fetal DevelopmentInternal medicinemedicinePerichondriumHumansMatrilin ProteinsRNA MessengerIn Situ HybridizationGlycoproteinsSkinExtracellular Matrix ProteinsCartilageCell DifferentiationDNAChondrogenesisSpineCell biologycarbohydrates (lipids)Collagen type I alpha 1Endocrinologymedicine.anatomical_structureCartilagePhenotypeJointsProteoglycansCollagenDecorinDevelopmental BiologyDevelopmental dynamics : an official publication of the American Association of Anatomists
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