Search results for "DEFICIENCY"
showing 10 items of 1071 documents
Hereditary combined deficiency of the vitamin K-dependent clotting factors
2010
Abstract Hereditary combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X as well as natural anticoagulants protein C, protein S and protein Z. The spectrum of bleeding symptoms ranges from mild to severe with onset in the neonatal period in severe cases. The bleeding symptoms are often life-threatening, occur both spontaneously and in a surgical setting, and usually involve the skin and mucosae. A range of non-haemostatic symptoms are often present, including developmental and skeletal anomalies. VKCFD is an autosomal recessive disorder caused by mutations in …
OP0159 THE EFFECT OF HIGH-INTENSITY RESISTANCE TRAINING AND VITAMIN D SUPPLEMENTATION ON MUSCLE STRENGTH IN PATIENTS WITH KNEE OSTEOARTHRITIS: A RAND…
2019
Background Exercise therapy is the cornerstone of knee osteoarthritis (OA) management. In particular muscle strengthening exercise, targeting the characteristic loss of muscle strength present in knee OA, is a key factor for the beneficial effects reported for exercise therapy. The optimal training intensity for resistance training in patients with knee OA, however, is not known to date. Besides resistance training, vitamin D supplementation in patients with vitamin deficiency may optimize muscle strength. Objectives To assess (i) whether high-intensity resistance training leads to greater improvements in muscle strength compared to moderate-intensity resistance training in patients with kn…
Vitamin D deficiency in South Europe: effect of smoking and aging
2012
Summary The main source of vitamin D is synthesis in the skin during exposure to ultraviolet radiation. The existence of photoaggravated diseases and the increasing incidence of skin cancer have prompted recommendations to avoid the sun. Here, we study the status of vitamin D in a healthy population and its relation to their habits of sun exposure. To do so, we designed a cross-sectional study that included 177 healthy people. We analyzed parameters about demographic data, sun exposure, and protection habits and estimated vitamin D dietary intake. We performed blood tests to measure serum 25-hydroxyvitamin D [25(OH)D], calcium, phosphorus, and intact parathyroid hormone. Mean levels (± stan…
A Shock to the System: HIV among Older African Women in Zimbabwe
2018
HIV remains a threat to the ordinary everyday life of older woman in African society. In what can be called “a reality shock,” HIV challenges most of the ordinary everyday endeavors in conservative African societies as it imposes new Western prevention, treatment, and health-management methods over long-held African traditions. The reality of the “Western” HIV epidemic, and its impact on the “African” ordinary everyday life, demands that the infected undergo a paradigm shift in order for them to live harmoniously within their society. This calls for a re-examination of traditional values and a strong sense of responsibility, courage, and determination to remain relevant and not be considere…
Cadmium availability at different soil pH to transgenic tobacco overexpressing ferritin
2003
International audience; Knowledge on physiological mechanisms and plant metabolism can be used to enhance metal uptake. The capacity to uptake metals of transgenic tobaccos overexpressing ferritin in plastids (P6) or in cytoplasm (C5) and a control tobacco (A) is assessed in three polluted soils from the same soil series, with a similar Cd content, but displaying pH from 5.8 to 7 (8b2, 8b3, S11). Differences in dry leave weight were not significant between the three tobaccos growing on each soil. Iron concentration in ferritin overexpression either in P6 or in C5 tobaccos increased only on the S11 soil, which had a soil pH 7, in comparison to A tobacco. In both 8b2 and 8b3 soils at pH lower…
How does sulfur deficiency modulate pea response to water stress? Impact on early developing and mature seeds
2018
National audience; Pea (Pisum sativum L.) produces seeds rich in proteins but yield and quality remain unstable across years due to various stresses. Sulfur (S) deficiency and water stress are two abiotic stresses that interact in the current context of climate change and low-input practices, and recent studies suggest an important role for sulfate transport and metabolism in the plant response to water stress. To investigate the interplay between sulfur nutrition and the water stress response, sulfate-deprived pea plants were subjected to a 9-days period of water stress during the early reproductive phase. While water stress did not impact seed yield, sulfur deficiency alone or combined wi…
Comment le mode de nutrition azotée influence-t-il le prélèvement, le stockage et la remobilisation des nutriments en conditions hydriques fluctuante…
2019
National audience; Pea seeds have interesting nutritional properties through their protein, vitamin and mineral contents. However, environmental conditions such as soil water availability during plant growth influence both final yield and seed quality in pea. Soil water conditions not only modulates pea nitrogen acquisition whatever the mode of nitrogen nutrition: mineral nitrogen acquisition by roots and atmospheric di-nitrogen fixation by nodules in interaction with rhizobia, but also the overall plant mineral nutrition. The aim of this study is to get a better understanding of soil water deficit impact on nutrient acquisition, storage and distribution inside the plant according to the mo…
Disentangling the complexity and diversity of crosstalks between S and other mineral nutrients in cultivated plants
2018
International audience
The plant resistance inducer β-aminobutyric acid (BABA) induces an iron deficiency response in A. thaliana
2012
β-aminobutyric acid (BABA) is a well-known plant resistance inducer. However, the molecular mechanisms underlying its effects are poorly understood. In the present study, we investigated whether BABA could act through the modification of iron homeostasis in Arabidopsis thaliana. Supporting this assumption, we obtained first evidences that BABA chelates iron with high affinity. We showed that pre-treatment of plants with BABA induced a drastic but transient iron deficiency response. Quantification of iron indicated that this response is related to the perturbation of iron distribution/availability rather than a reduction of iron assimilation. Finally, we provided evidence that the iron defic…
A holistic overview of the impact of sulfur deficiency in pea facing water deficit
2022
We report on the interplay between water deficit and sulfur deficiency, two constraints that are increasingly faced by crops due to climate change and low-input agricultural practices. In particular, we aim at better understanding the role of sulfur nutrition in the trade-off between seed quality establishment and plant stress tolerance in pea (Pisum sativum L.), a grain legume crop which has a pivotal role to play in both agroecological and food transitions. Like other legumes, pea is able to accumulate large amounts of seed proteins even in the absence of nitrogen fertilizers thanks to its symbiosis with N2-fixing soil bacteria. In this study, we deprived pea plants (cv. Caméor) of sulfur…