Search results for "DELE"

Transport of C(4)-dicarboxylates in Wolinella succinogenes.

2000

ABSTRACT C 4 -dicarboxylate transport is a prerequisite for anaerobic respiration with fumarate in Wolinella succinogenes , since the substrate site of fumarate reductase is oriented towards the cytoplasmic side of the membrane. W. succinogenes was found to transport C 4 -dicarboxylates (fumarate, succinate, malate, and aspartate) across the cytoplasmic membrane by antiport and uniport mechanisms. The electrogenic uniport resulted in dicarboxylate accumulation driven by anaerobic respiration. The molar ratio of internal to external dicarboxylate concentration was up to 10 3 . The dicarboxylate antiport was either electrogenic or electroneutral. The electroneutral antiport required the prese…

Zīmola "Andele Mandele" komunikācija un tās vērtējums

2017

Bakalaura darba nosaukums ir “Zīmola “Andele Mandele” komunikācija un tās vērtējums”. Pētījuma laikā tiek apskatīta zīmola Andele Mandele komunikācija un vērtēti ar to saistīti aspekti. Darba mērķis ir novērtēt zīmola Andele Mandele komunikāciju un lietotāju iesaistīšanos zīmola veidošanā, kā arī komunikācijas uztveri auditorijā. Pētījuma laikā izmantotas kvalitatīvās un kvantitatīvās pētniecības metodes, lai iegūtie dati tiktu savstarpēji papildināti. Darba gaitā veikta daļēji strukturēta intervija, aptauja, fokusa grupas diskusija un sekundāro datu analīze. Bakalaura darbs sastāv no trīs daļām: teorētiskā pamatojuma, izstrādātas pētījuma metodoloģijas un empīriskās daļas. Nobeigumā autore…

Endothelial Leptin Receptor Deletion Promotes Cardiac Autophagy and Angiogenesis Following Pressure Overload by Suppressing Akt/mTOR Signaling.

2019

Background: Cardiac remodeling is modulated by overnutrition or starvation. The adipokine leptin mediates energy balance between adipose tissue and brain. Leptin and its receptors are expressed in the heart. Methods and Results: To examine the importance of endothelial leptin signaling in cardiac hypertrophy, transverse aortic constriction was used in mice with inducible endothelium-specific deletion of leptin receptors (End.LepR-KO) or littermate controls (End.LepR-WT). End.LepR-KO was associated with improved left ventricular function (fractional shortening, 28.4% versus 18.8%; P =0.0114), reduced left ventricular dilation (end-systolic inner left ventricular diameter, 3.59 versus 4.08 m…

Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resist…

2007

In Candida albicans, the ATC1 gene, encoding a cell wall-associated acid trehalase, has been considered as a potentially interesting target in the search for new antifungal compounds. A phenotypic characterization of the double disruptant atc1Delta/atc1Delta mutant showed that it was unable to grow on exogenous trehalose as sole carbon source. Unlike actively growing cells from the parental strain (CAI4), the atc1Delta null mutant displayed higher resistance to environmental insults, such as heat shock (42 degrees C) or saline exposure (0.5 M NaCl), and to both mild and severe oxidative stress (5 and 50 mM H(2)O(2)), which are relevant during in vivo infections. Parallel measurements of int…

Pga13 in Candida albicans is localized in the cell wall and influences cell surface properties, morphogenesis and virulence.

2011

The fungal cell wall is an essential organelle required for maintaining cell integrity and also plays an important role in the primary interactions between pathogenic fungi and their hosts. PGA13 encodes a GPI protein in the human pathogen Candida albicans, which is highly up-regulated during cell wall regeneration in protoplasts. The Pga13 protein contains a unique tandem repeat, which is present five times and is characterized by conserved spacing between the four cysteine residues. Furthermore, the mature protein contains 38% serine and threonine residues, and therefore probably is a highly glycosylated cell wall protein. Consistent with this, a chimeric Pga13-V5 protein could be localiz…

NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines

1997

Proteomic Analysis of Saccharomyces cerevisiae Response to Oxidative Stress Mediated by Cocoa Polyphenols Extract

2020

The present study addressed the protective effects against oxidative stress (OS) of a cocoa powder extract (CPEX) on the protein expression profile of S. cerevisiae. A proteomic analysis was performed after culture preincubation with CPEX either without stress (&minus

Developments in Amphibian Parental Care Research : History, Present Advances, and Future Perspectives

2020

Despite rising interest among scientists for over two centuries, parental care behavior has not been as thoroughly studied in amphibians as it has in other taxa. The first reports of amphibian parental care date from the early 18th century, when Maria Sibylla Merian went on a field expedition in Suriname and reported frog metamorphs emerging from their mother's dorsal skin. Reports of this and other parental behaviors in amphibians remained descriptive for decades, often as side notes during expeditions with another purpose. However, since the 1980s, experimental approaches have proliferated, providing detailed knowledge about the adaptive value of observed behaviors. Today, we recognize mo…

Wandering through the Mesolithic. An archaeostatistical approach to explore the mobility patterns in eastern Iberia

2019

Abstract Tracing hunter-gatherer's mobility has been a recurring topic both in anthropological and archaeological literature. Following Binford's approach (1980), ethnographic comparisons have been brought out in order to better understand mobility patterns among Palaeolithic and Mesolithic groups, and how they relate with their environment, thus formulating a system where a main difference in mobility structure is pronounced on the distinction between residential and logistical camps. After some efforts made in order to relate the lithic record with such model (Clark and Barton, 2017), in this work we explore how lithic industry can be a reliable proxy for understanding the mobility patter…

Antiguas excavaciones, nuevas respuestas. El yacimiento epimagdaleniense de la Cova del Clot de l'Hospital (Roquetes, Baix Ebre)

2015

El objetivo de este trabajo ha sido estudiar los materiales obtenidos con las excavaciones de Francesc Esteve Gálvez en la Cova del Clot de l’Hospital (Bajo Ebro), yacimiento de finales del Pleistoceno-inicios del Holoceno, descubierto por él mismo el año 1945. La representación de raspadores, truncaduras, buriles y laminitas de dorso, entre otros tipos, permite atribuirlo al Epimagdaleniense, atribución corroborada por dos fechas radiocarbónicas sobre huesos de fauna: 11.115 y 10.045 BP. De esta forma, este yacimiento se suma a un numeroso conjunto de yacimientos del período citado, conocidos en las provincias de Tarragona y de Castellón de la Plana. Así mismo, el estudio de los restos fau…