Search results for "DEP"
showing 10 items of 10555 documents
Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1+ Chemoresistant Lung Cancer Cells
2022
Abstract Purpose: Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non–small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyte-independent, therapeutic activity of aPD-1 against NSCLC, blocking the tumor-intrinsic PD-1 receptors on chemoresistant cells. Experimental Design: PD-1 in NSCLC cells was explored in vitro at baseline, including stem-like pneumospheres, and following treatment with cisplatin both at transcriptional and protein levels. PD-1 signaling and RNA sequencing were assessed. The lymphocyte-independent antitumor activity of aPD-1 was explored in…
The influence of the out-of-family care institutions onto child’s development
2013
The article offers the analysis of the out-of-family care institutions and their influence on child’s development. Despite the fact that the institutional out-of-family care provides the subject with physical security and satisfies his basic needs it cannot provide the most important aspect of the development of the child - the close relationship with at least of one of the adults who would be able to captivate and become a legal guardian for several years.
Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up
2023
Background: Despite its high prevalence, the clinical course of pediatric migraine has not been fully understood, and previous studies present conflicting results. We present here the findings of a 10-year follow-up study involving children with severe migraine pain admitted to our emergency department. Furthermore, all studies were carried out on selected outpatient clinical case studies. Our aim was to evaluate a population of migraine children admitted to an emergency department because of increased severity or frequency of pain or even because of very anxious parents concerning their child’s headache in order to describe their long-term outcomes, whether it differed from that of o…
Charge-dependent flow and the search for the chiral magnetic wave in Pb-Pb collisions at √sNN = 2.76 TeV
2016
We report on measurements of a charge-dependent flow using a novel three-particle correlator with ALICE in Pb-Pb collisions at the CERN Large Hadron Collider (LHC), and discuss the implications for observation of local parity violation and the chiral magnetic wave (CMW) in heavy-ion collisions. Charge-dependent flow is reported for different collision centralities as a function of the event charge asymmetry. While our results are in qualitative agreement with expectations based on the CMW, the nonzero signal observed in higher harmonics correlations indicates a possible significant background contribution. We also present results on a differential correlator, where the flow of positive and …
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channe…
2021
Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases, monoamine oxidase A/B, and glycogen synthase kinase 3β and as calcium channel antagonists via the Biginelli multicomponent reaction. Among these MTDLs, (±)-BIGI-3h was identified as a promising new hit compound showing in vitro balanced activities toward the aforementioned recognized AD targets. Additional in vitro studies demonstrated antioxidant effects and brain penetration, along with the ability to inhibit the aggregation of both τ protein…
Effect of the color of the intraocular lens on optical and visual quality
2014
Purpose: To analyze the optical quality of intraocular lenses (IOL) with an orange (PC440Y) and a yellow (SN60AT) filter, and correlate these results with the visual quality of patients with these implants. Setting: Fisabio Oftalmología Médica, Valencia, Spain. Design: Randomized prospective study. Materials and Methods: The IOL optical quality was determined using the modulation transfer function (MTF) and the spectral transmission. The visual quality of 87 eyes with cataract (51 with orange filter and 36 with yellow filter) was determined by best corrected visual acuity (BCVA) and contrast sensitivity function (CSF) under photopic and mesopic conditions. To analyze the results, we use a S…
THERMOBIKE: aplicabilidad de la termografía infrarroja en la evaluación de la eficiencia, rendimiento y postura del ciclista
2017
La termografía infrarroja es una técnica de imagen no invasiva y a distancia que permite captar la radiación infrarroja emitida por los cuerpos, y con ello estimar su temperatura superficial. La termografía infrarroja es utilizada en muchos ámbitos, siendo algunos de los más importantes el sector militar y el industrial, seguida de otros sectores como el médico y el veterinario. La aplicación de la termografía infrarroja en el deporte es un tema reciente y existen aspectos a resolver en relación a la metodología, así como a su aplicación en el contexto de la evaluación del rendimiento deportivo en el ciclismo. En este sentido, la presente tesis doctoral tiene la siguiente hipótesis general:…
Sustainable recycling technologies for thermoplastic polymers and their composites: A review of the state of the art
2022
This review article discusses the environmental and economic effects of recycling, as well as sustainable thermoplastic polymer recycling technologies. Several researchers have utilized recycled thermoplastics as matrices in the production of a variety of natural and synthetic-based composites, which is also the focus of this study. All of the industries (food and packaging, construction and building, transportation, and indoor usage) where recycled thermoplastics have a large market share (food and packaging, construction and building, transportation, and indoor usage) are covered in this review. The desirable properties of thermoplastic polymers, such as corrosion resistance, low density,…
¿Quién decide qué y cómo? el conflicto en torno a la participación ciudadana en el contexto del desarrollo de la iniciativa urbana: Cuenca-San Antón …
2018
This article describes the main results of an ethnographic study on citizen participation carried out in the context of the development of the Urban Initiative (2007-2015): Cuenca-Barrio de San Antón. Managed by the City Council of Cuenca and financed by the European Regional Development Funds (FEDER) under the Ministry of Economy and Finance at the Government of Spain The results of the research show how in the context of the application of neoliberal policies, citizen participation becomes the trigger for new conflicts between institutions and citizens. In this sense, it is worth noting how, in practice, institutions in their capacity as experts and not willing to dis-empower themselves, …
Victor Schoelcher, abolitionniste et républicain : approche juridique et politique de l'oeuvre d'un fondateur de la République
2000
The aim of this judicial and political analysis is to reveal Victor Schoelcher's decisive influence in the fight for equal rights and for the republic, in the French mainland as well as in its colonies. His well known fight against slavery was just a part of his humanist defense of the republican principles : Liberty, Equality, Fraternity. Schoelcher truly was a founder of the republic, taking part in the barricade insurrections against the 1851 coup and fighting against any kind of slavery or absolutism. His work addressed many aspects of our society, among which : - Slavery and the colonies (legal status of slaves, emancipated slaves and of the colonies) - Rights and liberties of men and …