Search results for "DEP"
showing 10 items of 10555 documents
Advancing stem cells: New therapeutic strategies for treating central nervous system disorders
2018
In this special issue, we explore new methods and knowledge to improve stem cell transplantation in diseases and conditions such as stroke, PD, and depression. Advancing the conventional idea regarding cell replacement in stem cell therapy, stem cells may also transfer healthy mitochondria to diseased ischemic neurons in stroke and improve the therapeutic time window of tissue plasminogen activator (tPA) in a conjunctive therapy for stroke, and human Wharton’s Jelly-derived mesenchymal stromal cells (hWJ-MSCs) may rely mainly on trophic factor secretion to induce neuroprotective effects. In addition, trophic factors such as neurotrophin-4/5 (NT-4/5) and glial cell line-derived neurotrophic …
Characterization of the seismic dynamical state through joint analysis of earthquakes and seismic noise: the example of Ischia Volcanic Island (Italy)
2020
This work is devoted to the study of both earthquakes and background seismic noise at Ischia Island (Italy) recorded pre and post the Md 4.0 earthquake occurred on 21 August 2017 (18:57 UTC). We compare and characterize noise and earthquakes in terms of Independent Component Analysis, energy and polarization properties. The earthquakes' waveforms and the background noise are decomposed into a few independent components with two main common signals peaked around 1–2 and 3–4 Hz, respectively. A slight increase of the energy of the background seismic noise is observed comparing samples recorded in 2016 and 2017, whereas no variations are detected in 2017 pre and post the main ear…
LFER and the Effect of Temperature on Oxyanion Adsorption by Goethite
2019
A linear relationship between the Gibbs free energy, ΔGr,H+, of the aqueous complex deprotonation reaction, and the Gibbs free energy, ΔGr,ads, of bidentate surface complexation reaction of oxyanions was derived from modelling of temperature dependent batch equilibrium adsorption experiments. As exemplified in this study, this relationship may be exploited to predict temperature-dependent adsorption behavior of oxyanions not yet known such as pertechnetate.
EL FÚTBOL COMO POTENCIADOR DE TURISMO DEPORTIVO
2018
El turismo deportivo se puede definir como un viaje de ocio con el fin de participar, de distintas formas, en actividades físico-deportivas. Respecto al fútbol, sus encuentros constituyen grandes eventos deportivos, atracciones donde el turista vivencia, principalmente de forma pasiva, distintas actividades, ya sea como espectador o como visitante de las atracciones turístico-futbolísticas. Sin duda, el fútbol tiene un importante valor turístico, en especial para la estructura turística local, incidiendo de manera directa en aspectos como la promoción y difusión de un destino turístico. En este marco, los clubs de fútbol se convierten en promotores turísticos de su ciudad, además de desarro…
Decision-Making Tools to Manage the Microbiology of Drinking Water Distribution Systems
2020
[EN] This paper uses a two-fold multi-criteria decision-making (MCDM) approach applied for the first time to the field of microbial management of drinking water distribution systems (DWDS). Specifically, the decision-making trial and evaluation laboratory (DEMATEL) was applied removing the need for reliance on expert judgement, and analysed interdependencies among water quality parameters and microbiological characteristics of DWDS composed of different pipe materials. In addition, the fuzzy technique for order preference by similarity to ideal solution (FTOPSIS) ranked the most common bacteria identified during trials in a DWDS according to their relative abundance while managing vagueness…
Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer ste…
2018
Despite marked advancements in its treatment, breast cancer is still the second leading cause of cancer death in women, due to relapses and distal metastases. Breast cancer stem cells (CSCs), are a cellular reservoir for recurrence, metastatic evolution and disease progression, making the development of novel therapeutics that target CSCs, and thereby inhibit metastases, an urgent need. We have previously demonstrated that the cystine-glutamate antiporter xCT (SLC7A11), a protein that was shown to be overexpressed in mammary CSCs and that plays a key role in the maintenance of their redox balance, self-renewal and resistance to chemotherapy, is a potential target for mammary cancer immunoth…
Human γδ T-Cells: From Surface Receptors to the Therapy of High-Risk Leukemias
2018
γδ T lymphocytes are potent effector cells, capable of efficiently killing tumor and leukemia cells. Their activation is mediated by γδ T-cell receptor (TCR) and by activating receptors shared with NK cells (e.g., NKG2D and DNAM-1). γδ T-cell triggering occurs upon interaction with specific ligands, including phosphoantigens (for Vγ9Vδ2 TCR), MICA-B and UL16 binding protein (for NKG2D), and PVR and Nectin-2 (for DNAM-1). They also respond to cytokines undergoing proliferation and release of cytokines/chemokines. Although at the genomic level γδ T-cells have the potential of an extraordinary TCR diversification, in tissues they display a restricted repertoire. Recent studies have identified …
Advanced chronic kidney disease. Association between anxiety, depression and resilience
2019
Resumen Introducción: el padecimiento de la enfermedad renal crónica avanzada (ERCA) se asocia con una mayor probabilidad de padecer sintomatología depresiva y ansiosa. No obstante, la resiliencia puede amortiguar estos efectos. El objetivo general fue valorar la sintomatología ansiosa, depresiva y la resiliencia de los pacientes con ERCA. Métodos: 70 pacientes (80 % varones), con edades entre 38-88 años (M=68,88; DT= 9,98) fueron evaluados mediante la Escala Hospitalaria de Ansiedad y Depresión y la de Resiliencia de Connor Davidson. Se realizaron análisis descriptivos, pruebas t, d de Cohen y correlaciones de Pearson. Resultados: un 41,79 % presentó sintomatología ansiosa y un 25,38 % dep…
LA CRISIS ECONÓMICA COMO OPORTUNIDAD PARA REPENSAR LAS RELACIONES DE GÉNERO
2012
Resumen: Las situaciones de crisis son poco propicias para sostener reivindicaciones igualitaristas, tanto por el lado de la desinversión en medidas reparadoras de la desigualdad como por el de la presión de sectores refractarios a la emancipación. Se revelan así algunos déficits sustanciales en la producción reciente de ciencia social y de políticas públicas desde la perspectiva del género, incapaces aún de aportar una cultura antidiscriminatoria consistente. Aquí se plantea una reflexión sobre el género que pueda basar nuevos discursos y nuevas políticas reorientadas hacia la igualdad, subrayándose la importancia de los movimientos sociales y de las alianzas horizontales en su seno. Abstr…
Sobre el teatre independent valencià i la nova escriptura teatral
2015
This article aims to study the independent Valencian drama (1968-1978) especially the activity of the groups who work with the Catalan language. In the first part there is a review of the development of this movement, centered above all on the relationship that these groups had with the Valencian drama tradition. The second part reviews the most remarkable dramatists and groups of the period: Josep Lluís Sirera, Rodolf Sirera, Manuel Molins and the Group 49, Pluja Teatre and Juli Leal and Carnestoltes.