Search results for "DEPICT"

showing 10 items of 29 documents

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

2018

International audience; C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 1…

0301 basic medicineMaleNetherlands Twin Register (NTR)Bipolar DisorderLD SCORE REGRESSION[SDV]Life Sciences [q-bio]Genome-wide association study[SDV.GEN] Life Sciences [q-bio]/GeneticsBody Mass Indexinflammatory disorder80 and overWIDE ASSOCIATIONEPIDEMIOLOGYta318International HapMap ProjectChildGenetics (clinical)2. Zero hungerGeneticsGenetics & HeredityAged 80 and over[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyC-reactive proteingenome-wide association studyinflammationMendelian randomizationinflammatory disordersDEPICTcoronary artery diseaseschizophreniasystem biologysystem biologyDEPICTMendelian Randomization Analysis11 Medical And Health SciencesMiddle AgedC-reactive protein; coronary artery disease; DEPICT; genome-wide association study; inflammation; inflammatory disorders; Mendelian randomization; schizophrenia; system biology; Adolescent; Adult; Aged; Aged 80 and over; Biomarkers; Bipolar Disorder; Body Mass Index; C-Reactive Protein; Child; Female; Genetic Loci; Genome-Wide Association Study; Humans; Inflammation; Liver; Male; Mendelian Randomization Analysis; Metabolic Networks and Pathways; Middle Aged; Schizophrenia; Young Adult3. Good health[SDV] Life Sciences [q-bio]LiverMedical geneticsBiomarker (medicine)/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemaleinflammatory disordersLife Sciences & BiomedicineMetabolic Networks and Pathwayscoronary artery diseaseHumanAdultmedicine.medical_specialtyAdolescentCHARGE Inflammation Working GroupC-reactive protein ; DEPICT ; Mendelian randomization ; coronary artery disease ; genome-wide association study ; inflammation ; inflammatory disorders ; schizophrenia ; system biologyBiologyIMMUNITYta3111ArticleC-reactive protein03 medical and health sciencesYoung AdultSDG 3 - Good Health and Well-beingMendelian randomizationGeneticsmedicine/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_Mendelian randomizationHumansCORONARY-HEART-DISEASEMendelian Randomization Analysi1000 Genomes ProjectMETAANALYSISGenetic associationAged[SDV.GEN]Life Sciences [q-bio]/GeneticsScience & Technologygenome-wide association studyta1184Metabolic Networks and PathwayBiomarkerINSTRUMENTS06 Biological SciencesMendelian Randomization Analysisschizophrenia030104 developmental biologyGenetic LociinflammationC-reactive protein; DEPICT; Mendelian randomization; coronary artery disease; genome-wide association study; inflammation; inflammatory disorders; schizophrenia; system biology[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyBiomarkersLifeLines Cohort Study
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NOTES ON A STATUE FROM THE COLLECTIONS OF THE NATIONAL MUSEUM OF UNION FROM ALBA IULIA

2016

This study proposes to re-evaluate a marble statue from the old collections of the National Museum of Union Alba Iulia. It was discovered by A. Cserni during excavations carried out at the Palace of the Governors of Roman Dacia, in 1898. It has been repeatedly published by Á. Hekler and Al. Diaconescu. While the latter author established dating and iconographic prototype of the statue, we believe that further details as discovery place and context, depiction, iconographic attribution and role of this work of art can be offered. Presence of a follower at the feet of the divinity, more precisely the right foot of a character – child, conveys us the idea of depiction of Eros, god of love. Usua…

ArcheologyHistorybusiness.industryapulum eros goddess marble statue prototype venus.Art historyContext (language use)Character (symbol)Representation (arts)Ancient historyD51-90PoliticsArchaeologyDivinityMedicineDepictionStatueClassicsbusinessCC1-960EclecticismJOURNAL OF ANCIENT HISTORY AND ARCHAEOLOGY
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Icarus and Daedalus in Toni Morrison's "Song of Solomon"

2012

In Song of Solomon Toni Morrison rewrites the legend of the Flying Africans and the Myth of Icarus to create her own Myth. Her depiction of the black hero’s search for identity has strong mythical overtones. Morrison rescues those elements of mythology black culture which are still relevant to blacks and fuses them with evident allusions to Greek mythology. She reinterprets old images and myths of flight, the main mythical motif in the story. Her Icarus engages on an archetypical journey to the South, to his family past, led by his Daedalic guide, on which he finally recovers his ancestral ability to fly. His flight signals a spiritual epiphany in the hero’s quest for self-definition in the…

Cultural StudiesLinguistics and LanguageHistoryLiterature and Literary Theorydaedalusmedia_common.quotation_subjectPE1-3729Language and LinguisticsMotif (narrative)icarusHEROidentitymedia_commonLiteratureICARUSquestbusiness.industryMythologymythLegendEnglish languageflightEpiphanyDepictionbusinessGreek mythologyJournal of English Studies
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The State of the Unions

2021

What defines an economic region and distinguishes it from other spatial concepts? This fundamental question is addressed based on the dimensions of space, borders, action and time. An overview of the landscape of African Regional Economic Communities (RECs) follows. RECs are briefly portrayed, and the bewildering multitude of RECs is demystified to create a better understanding of the pattern of economic integration in Africa. The exercise is guided by a matrix of general-purpose versus functional/sectoral as well as effectual versus ineffectual/dormant economic unions. This analysis forms the basis for a critical discussion of the African Union’s practice of only granting official recognit…

Economic integrationAction (philosophy)State (polity)Economic regionPolitical economyPolitical sciencemedia_common.quotation_subjectMultitudeDepictionSpace (commercial competition)media_commonCritical discussion
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David Malcolm Raup (1933-2015) at the starting point of a new paradigm for Palaeontology

2020

This is a tribute to the late David Malcolm Raup, one of the major palaeontologists of the second half of the 20 th century. In addition, it is a critical review of his outstanding contributions, mainly in the field of theoretical palaeontology: quantitative modelling, the introduction of probabilistic methods in palaeontology, as well as his great imagination to use techniques from other fields, such as insurance actuary. After a general outline of his youth, I present a general depiction of the main topics of his research as a palaeobiologist: morphology, the structure of the fossil record, evolution, and extinction. He covered areas ranging from the theoretical morphology of coiled shell…

Extinction eventPaleontologyHistoryExtinctionFossil RecordPoint (typography)fossil record evolution extinction time series simulationTributeDepictionPaleontologyMorphology (biology)QE701-760Theoretical morphologySpanish Journal of Palaeontology
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Glasgow ou l’Écosse urbaine dans les poèmes de Hugh MacDiarmid

2012

Hugh MacDiarmid is sometimes still thought a parochial poet, mostly interested in the depiction of rural Scotland. However, in the 1930s, he wrote several poems about the city of Glasgow but his work on urban predicaments has been largely forgotten. In his Glasgow sequence, MacDiarmid, along with many other writers in the 30s, redefines Scotland as an urban nation. Post-industrial Glasgow urges the whole country to ‘re-write’ itself and the canonical representation of rural Scotland to fade away. Scotland is mercilessly deconstructed in Glasgow 1938: Glasgow is no longer ‘a dear green place’, Scotland no longer a land of peasants but urban hell where filthy disease and dirty capitalism spre…

Glasgow 1938History[SHS.LITT]Humanities and Social Sciences/LiteraturehellÉcosseillocutionnairemedia_common.quotation_subjectlangage performatifArt historyPerformative utteranceCapitalismGlasgowCapitalisme[SHS]Humanities and Social Sciences[SHS.LITT] Humanities and Social Sciences/LiteratureFaithenferPoliticsindustrialisationCommunismCommunismmedia_commonperlocutionaryillocutionaryPoetryrun-on-lineSentimentalitynominalisationcommunismeenjambementcultureCalvinismScotlandDepictionperformative[SHS] Humanities and Social SciencesHugh MacDiarmidHumanitiesÉtudes écossaises
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Alan Moore's America: The Liberal Individual and American Identities in Watchmen

2011

core is an ensemble of diverse characters that explores fundamental issues for American national identity during the second half of the twentieth century. Moore’s work performs thi st ask in two ways, fi rstly, by presenting a group of diverse ideologically contingent American figures in the individual characters, and secondly, by highlighting a sacrosanct element of America’s image of itself, the primacy of the ‘‘liberal individual’’ not just as an American type but as the naturalized core of the national ethos. This article maps this subject identity into a national identity such as that typified in Benedict Anderson’s Imagined Communities ,as mall-n nationalism as a successor to kinship …

HistoryHistoryLiterature and Literary TheoryCulture of the United StatesAnthropologyIdentity (social science)Art historyNationalismEthosPoliticsArts and Humanities (miscellaneous)Collective identityNational identityDepictionThe Journal of Popular Culture
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Singing the News of Punishment

2021

Abstract This article explores the pan-European phenomenon of the execution ballad, songs that told the news of true crimes and their punishment by public execution. Looking at examples across nine languages, from the sixteenth through the nineteenth century, this comparison reveals that these ballads share multiple features in textual content and format: a recognisable, formulaic narrative; sensationalist and emotive language; and a conservative perspective that confirms that the condemned is guilty and that ‘justice’ is being served. We also note key regional differences, such as in the use (or not) of contrafactum, the setting of new lyrics to familiar melodies, in the use of the first v…

HistoryHistoryPunishmentmedia_common.quotation_subjectComparative literatureMedia studiesLibrary and Information SciencesLyricsEconomic JusticeBalladEmotiveDepictionNarrativemedia_commonQuaerendo
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Bernardine Evaristo’s The Emperor’s Babe: Re-narrating Roman Britannia, De-essentialising European History

2019

Bernardine Evaristo’s The Emperor’s Babe (2001) contributes to the imaginative disentanglement of the traditional British ethnicity-and-nation nexus and questions the related founding myth of racial purity by featuring the character of Zuleika, a young black woman who is born of Sudanese parents in Roman London. Through the depiction of Zuleika, Evaristo offers a subversive reshaping of some versions of the official British national history in the context of a wider revision of the European classical past. However, in spite of its temporal setting, Evaristo’s historical novel simultaneously engages with contemporary issues of gendered racialisation and national belonging. In its highly orch…

Historybiologymedia_common.quotation_subjectcommoncommon.demographic_typeBernardine EvaristoArt historyContext (language use)Mythologybiology.organism_classificationRacismBlack BritishRoman EmpireBlack womenEmperorDepictionRoman Londonblack cultureCitizenshipmedia_commonSynthesis: an Anglophone Journal of Comparative Literary Studies
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How Do Viewers Spontaneously Segment Animated Diagrams of Mechanical and Biological Subject Matter?

2012

A challenges for learning from animated diagrams is to first parse the continuous flow of information into discrete event units. Inadequacies in this parsing process can prejudice the quality of the mental model constructed from the depiction. One approach that has been proposed for ameliorating such problems is for the designer to pre-segment the animation. However, the pre-segmentation techniques used tend to be either intuitive or based on an expert's understanding of the subject matter. Neither of these approaches takes proper account of the psychological processing that must occur for an external animation to be properly internalized. This poster reports a study of the processes that l…

Identification (information)ParsingMultimediaComputer scienceHuman–computer interactionProcess (engineering)Event (computing)DepictionSegmentationAnimationMacrocomputer.software_genrecomputer
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