Search results for "DIABETES MELLITUS"

showing 10 items of 2077 documents

Microsatellite allele A5.1 of MHC class I chain-related gene A is associated with latent autoimmune diabetes in adults in Latvia.

2006

NIDDM is one of the most common forms of diabetes. The diagnosis is based on WHO classification, which is a clinical classification and misses the autoimmune diabetes in adults. Therefore, among the clinically diagnosed NIDDM cases, there can be a certain number of patients with latent autoimmune diabetes in adults (LADA). The MICA gene is located in the MHC class I region and is expressed by monocytes, keratinocytes, and endothelial cells. Sequence determination of the MICA gene identifies trinucleotide repeat (GCT) microsatellite polymorphism, which identifies 5 alleles with 4, 5, 6, and 9 repetitions of GCT (A4, A5, A6, and A9) or 5 repetitions of GCT with 1 additional G insertion for al…

AdultMaleGeneral Biochemistry Genetics and Molecular Biologylaw.inventionHistory and Philosophy of ScienceGene FrequencylawDiabetes mellitusMHC class ImedicineHumansGenetic Predisposition to DiseaseAlleleAge of OnsetPolymerase chain reactionAllelesbiologyGeneral NeuroscienceHistocompatibility Antigens Class Imedicine.diseaseLatviastomatognathic diseasesDiabetes Mellitus Type 2HaplotypesImmunologybiology.proteinMicrosatelliteFemaleAge of onsetAntibodyTrinucleotide repeat expansionMicrosatellite RepeatsAnnals of the New York Academy of Sciences
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Different KIRs Confer Susceptibility and Protection to Adults with Latent Autoimmune Diabetes in Latvian and Asian Indian Populations

2008

KIRs (killer Ig-like receptors) expressed on natural killer (NK) cells are an important component of innate (and adaptive) immunity. They are either activatory or inhibitory, and certain KIRs are known to interact with specific motifs of HLA Class I molecules, which is very crucial in determining whether a cell is targeted to lysis or otherwise. Latent autoimmune diabetes in adults (LADA) is a slowly progressive form of autoimmune diabetes, with an adult onset (>30 years). Because autoantibodies and autoimmunity involved are involved in the etiology of LADA, KIRs might play an important role in conferring susceptibility to or protection against the disease. The purpose of this study was to …

AdultMaleGenotypeIndiachemical and pharmacologic phenomenaHLA-C AntigensHuman leukocyte antigenDiseaseBiologymedicine.disease_causeGeneral Biochemistry Genetics and Molecular BiologyAutoimmunityGene FrequencyPopulation GroupsReceptors KIRHistory and Philosophy of Scienceimmune system diseasesImmunityotorhinolaryngologic diseasesmedicineHumansGenetic Predisposition to DiseaseReceptorGenotypingType 1 diabetesPolymorphism GeneticGeneral NeuroscienceAutoantibodyhemic and immune systemsMiddle Agedmedicine.diseaseLatviaDiabetes Mellitus Type 1CytoprotectionCase-Control Studiesembryonic structuresImmunologyFemaleAnnals of the New York Academy of Sciences
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Long-Term Determinants of Muscle Strength Decline: Prospective Evidence from the 22-Year Mini-Finland Follow-Up Survey

2012

Objectives: To examine long-term changes in handgrip strength and the factors predicting handgrip strength decline. Design: Longitudinal cohort study with 22 years of follow-up. Setting: Population-based Mini-Finland Health Examination Survey in Finland. Participants: Nine hundred sixty-three men and women aged 30 to 73 at baseline. Measurements: Handgrip strength was measured using a handheld dynamometer at baseline and follow-up. Information on potential risk factors, namely lifestyle and chronic conditions, and their changes throughout the follow-up were based on health interviews. Results: Based on linear mixed-effect models, midlife physically strenuous work, excess body weight, smokin…

AdultMaleGerontologyAgingSarcopeniaChronic bronchitisMuscle Strength Dynamometermedicine.medical_specialtyTime FactorsPopulationMuscle Strength DynamometerDiseasePredictive Value of TestsRisk FactorsWeight lossSurveys and QuestionnairesDiabetes mellitusActivities of Daily LivingmedicineHumansMuscle StrengthProspective StudiesProspective cohort studyeducationGeriatric AssessmentFinlandAgededucation.field_of_studyHand Strengthbusiness.industryIncidenceMiddle Agedmedicine.diseaseHealth SurveysMiddle ageDisease ProgressionPhysical therapyFemaleGeriatrics and Gerontologymedicine.symptombusinessFollow-Up StudiesJournal of the American Geriatrics Society
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No association between periodontal disease and GHQ-12 in a Brazilian Police population

2010

Objectives: We attempt to investigate a possible association between periodontal disease (PD) and mental disorders (MD) in a population of Brazilian Police. Study Method: From a total study population consisting of 803 policemen, 345 police officers were obtained by a sample calculation using the finite population correction who were randomly selected in Montes Claros, Minas Gerais, Brazil. Patients who had been prescribed steroids or those diagnosed with diabetes and cardiovascular diseases were excluded from this study. The General Health Questionnaire (GHQ-12) was used to assess mental disorders. Odds ratios (ORs) for periodontal diseases severity and their respective 95% confidence inte…

AdultMaleGerontologyPopulationYoung Adultsymbols.namesakeSurveys and QuestionnairesDiabetes mellitusHumansMedicinePoisson regressioneducationGeneral DentistryPeriodontal Diseaseseducation.field_of_studybusiness.industryMental DisordersIncidence (epidemiology)Odds ratioMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseasePoliceConfidence intervalOccupational DiseasesOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASsymbolsPopulation studyFemaleSurgeryGeneral Health QuestionnairebusinessBrazilDemographyMedicina Oral Patología Oral y Cirugia Bucal
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Transtheoretical model-based dietary interventions in primary care: a review of the evidence in diabetes

2008

The objective of this study was to review the evidence concerning stage-based dietary interventions in primary care among persons with diabetes or an elevated diabetes risk. Search strategies were electronic databases and manual search. Selection criteria were randomized controlled studies with stage-based dietary intervention, conducted in primary care with at least 6 months of follow-up, and participants with either type 2 diabetes or with an elevated risk. The researchers evaluated trials for inclusion, extracted data and assessed study quality. Seven articles, based on five data sets, were included. These studies concentrated on cardiovascular diseases and being overweight, not diabetes…

AdultMaleGerontologymedicine.medical_specialtyDiabetes riskDiet therapyPsychological interventionType 2 diabetesOverweightEducationHealth careDiabetes MellitusmedicineHumansAgedEvidence-Based MedicinePrimary Health Carebusiness.industryPublic Health Environmental and Occupational HealthTranstheoretical modelOriginal ArticlesMiddle AgedModels Theoreticalmedicine.diseaseSystematic reviewPhysical therapyFemalemedicine.symptombusinessHealth Education Research
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Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial

2022

AbstractThe STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes. The co-primary endpoints were the percentage change in body weight and achievement of weight loss of ≥5% at week 104. Efficacy was assessed among all randomized participants regardless of treatment discontinuation or rescue intervention. From 5 October 2018 to 1 February 2019, 304 participants were randomly assigned to semaglutide 2.4 mg (n = 152) or placebo (n = 152), 92.8% of whom completed the trial (attended t…

AdultMaleGlucagon-Like PeptideHypoglycemic AgentObesidadInvestigación médicaGeneral MedicineMiddle AgedOverweightWeight LoGeneral Biochemistry Genetics and Molecular BiologyTratamiento médicoTreatment OutcomeDouble-Blind MethodDiabetes Mellitus Type 2GlucemiaControl glucémicoFemaleObesitySettore MED/49 - Scienze Tecniche Dietetiche ApplicateHuman
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Sleep quality does not mediate the negative effects of chronodisruption on body composition and metabolic syndrome in healthcare workers in Ecuador

2020

Abstract Background and aims The objective of the present work was to determine to what extent sleep quality may mediate the association between chronodisruption (CD) and metabolic syndrome (MS), and between CD and body composition (BC). Methodology Cross-sectional study which included 300 adult health workers, 150 of whom were night shift workers and thereby exposed to CD. Diagnosis of MS was made based on Adult Treatment Panel III criteria. Sleep quality was measured using the Pittsburgh Sleep Quality Index. Body mass index (BMI), fat mass percentage, and visceral fat percentage were measured as indicators of body composition (BC). Data were analyzed using logistic, linear regression and …

AdultMaleHealth PersonnelEndocrinology Diabetes and MetabolismPhysiologyChronobiology DisordersFat massShift workPittsburgh Sleep Quality Index03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingWork Schedule ToleranceDiabetes mellitusHealth careInternal MedicinemedicineHumans030212 general & internal medicineSDG 7 - Affordable and Clean EnergyExerciseChronobiology PhenomenaMetabolic SyndromeSleep qualitybusiness.industryGeneral MedicineMiddle Agedmedicine.disease030210 environmental & occupational healthCross-Sectional StudiesBody CompositionFemaleEcuadorMetabolic syndromeEnergy IntakeSleepbusinessBody mass indexDiabetes and Metabolic Syndrome: Clinical Research and Reviews
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Obese Subjects Carrying the 11482G>A Polymorphism at the Perilipin Locus Are Resistant to Weight Loss after Dietary Energy Restriction

2005

Dietary treatment of obesity could be improved if predictive information about the individual's genetic response to diet was available. Adipose tissue has been the focus of efforts to identify candidate genes. Perilipin is a major protein found in adipocytes, and perilipin knockout mice are lean and resistant to diet-induced obesity.The objective of the study was to examine the association of several polymorphisms at the perilipin (PLIN) locus with obesity and weight reduction in response to a low-energy diet in obese patients.This study was a 1-yr randomized (depending on the PLIN genotype) trial with three follow-up evaluations.The study was conducted at a university research center.One h…

AdultMaleHeterozygotePerilipin-1medicine.medical_specialtyCandidate geneGuanineEndocrinology Diabetes and MetabolismClinical BiochemistryAdipose tissueBiologyBiochemistryEndocrinologyWeight lossInternal medicineWeight LossGenotypePrevalencemedicineHumansObesityAlleleAllelesAgedCaloric RestrictionPolymorphism GeneticAdenineBiochemistry (medical)Middle AgedPhosphoproteinsmedicine.diseaseObesityEndocrinologyDiabetes Mellitus Type 2PerilipinFemalemedicine.symptomCarrier ProteinsBody mass indexThe Journal of Clinical Endocrinology & Metabolism
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Adrenal morphology and function in acromegalic patients in relation to disease activity.

2009

Visceromegaly is a common consequence of acromegaly. However, few studies investigated the chronic effects of growth hormone on adrenal glands. Our aim was to evaluate adrenal morphology and function in a cohort of acromegalic patients in relation to disease activity. Twenty-six acromegalics (10 males and 16 females) and 21 healthy subjects were investigated. Gland morphology was evaluated by computerized axial tomography, measuring central, lateral, and medial adrenal segments. Uncontrolled acromegalics showed increased volume of all adrenal segments, higher urinary free cortisol (UFC), and lower morning adrenocorticotropic hormone in comparison with healthy subjects. However, normal corti…

AdultMaleHypothalamo-Hypophyseal Systemmedicine.medical_specialtyEndocrinology Diabetes and MetabolismPituitary-Adrenal SystemAdrenocorticotropic hormoneCardiovascular SystemSeverity of Illness IndexSettore MED/13 - EndocrinologiaEndocrinologyDiabetes mellitusInternal medicineAdrenal GlandsAcromegalymedicineHumansAgedMorningbusiness.industryAdrenal glandCase-control studyOrgan SizeMiddle Agedmedicine.diseaseEndocrinologymedicine.anatomical_structureAcromegaly Growth hormone Adrenal gland CortisolCase-Control StudiesDexamethasone suppression testAcromegalyDisease ProgressionFemalebusinessVisceromegaly
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Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients

1989

In this study, we investigated whether an interleukin 2 (IL-2) secretion defect by peripheral blood mononuclear cells (PBMCs) after in vitro stimulation with phytohemagglutinin (PHA-M) occurs in either newly diagnosed or long-standing type I (insulin-dependent) diabetic patients and whether it is accompanied by a dysregulation of soluble IL-2— receptor (IL-2RS) production. PBMC cultures (2.5 × 106 cells), unstimulated or stimulated with PHA-M (25 μg/ml), from 20 type I diabetic patients (10 with time since onset <3 mo and 10 with long-term diabetes of <3 yr) and 10 control subjects were studied for the production of IL-2 and IL-2RS in their respective supernatants. No differen…

AdultMaleInterleukin 2medicine.medical_specialtyTime FactorsAdolescentEndocrinology Diabetes and MetabolismStimulationPeripheral blood mononuclear cellIn vivoInternal medicineInternal MedicinemedicineHumansSecretionPhytohemagglutininsChildReceptorCells Culturedbusiness.industryLymphokineReceptors Interleukin-2In vitroDiabetes Mellitus Type 1EndocrinologySolubilityLeukocytes MononuclearInterleukin-2Femalebusinessmedicine.drug
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