Search results for "DIABETES"

NEO1 and NEO-EXT studies: Long-term safety of repeat avalglucosidase alfa dosing for 4.5 years in late-onset Pompe disease patients

2019

Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat avalglucosidase alfa dosing (5, 10, or 20 mg/kg qow) for 6 months were evaluated in NEO1 (NCT01898364) in late-onset Pompe disease patients either treatment-naive (Naive) or having received alglucosidase alfa for ≥9 months (Switch). In NEO-EXT (NCT02032524), an ongoing NEO1 extension, long-term safety and pharmacokinetics of repeat avalglucosidase alfa dosing will be monitored over 6 years. Interim safety results after 4.5 years of NEO-EXT are reported here. Mean ages at NEO1 enrollment were: Naive: 44.8 (SD:20.3, range:20-78) years and Switch: 46.7 (SD:14.1, range:21-68) years. Of the 24 NEO1 parti…

Management of Statin Intolerance in 2018: Still More Questions Than Answers.

2018

Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutra…

Three-year mortality after acute myocardial infarction in patients with different diabetic status

2021

Introduction: The prevalence of diabetes mellitus (DM) in patients with myocardial infarction (MI) is estimated at about 25%. Short and long-term prognoses are worse in DM and hyperglycemia compared with non-diabetics. Objectives: Our aim was to analyze the impact of DM and transient hyperglycemia on in-hospital complications and long-term outcomes in MI patients. Patients and Methods: We evaluated a prospective cohort of 58,394 MI patients in the Polish Registry of Acute Coronary Syndrome in terms of in-hospital complications and 30-day, 12-month, and 36-month outcomes between 2009–2012. Results: Type 1 and 2 DM patients underwent invasive diagnostic and therapeutic procedures less frequen…

The impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease

2021

This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total of 63 eligible women randomly participated in the Nordic walking training (AEx, n = 33), or maintained their daily lifestyle (Con, n = 30) during intervention. Bone mineral content (BMC) and density (BMD) of whole body (WB), total femur (TF), femoral neck (FN), and lumbar spine (L2-4) were assessed by dual-energy X-ray absorptiometry. Serum osteocalcin, pentosidine, receptor activator of nuclear factor kappa-B ligand (RANKL) levels were analyzed by ELISA assay. After an 8.6-month intervention, the AEx group maintained their BM…

Serum metabolic profiles in overweight and obese women with and without metabolic syndrome.

2014

Objective: To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body weight and fat mass. Methods: We applied nuclear magnetic resonance spectroscopy-based profiling of fasting serum samples to examine the metabolic differences between 78 previously physically inactive, body weight and fat mass matched overweight/obese premenopausal women with and without MetS. MetS was defined as the presence of at least three of the following five criteria: waist circumference ≥ 88 cm, serum triacylglycerol ≥ 1.7 mmol/L, and high density lipoprotein cholester…

Fyysinen aktiivisuus ja metabolinen oireyhtymä 55-74-vuotiailla miehillä ja naisilla

2004

Verbal and academic skills in children with type 1 diabetes

2011

Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease

2021

Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH) (n = 32)

Nuorten aikuisten tyypin 1 diabeetikoiden diabetes-spesifi elämänlaatu ja liikunta

2015

Tyypin 1 diabeetikoiden määrä kasvaa kansallisesti sekä kansainvälisesti. Sairauteen liittyy kysymyksiä varsinkin hoidon jatkuvaan ylläpitoon liittyen ja diabeetikoiden elämänlaadun on todettu olevan huonompaa verrattuna verrokkiväestöön. Liikunta aiheuttaa myös oman erityispiirteensä hoidon toimivuuteen. Tämän tutkimuksen tarkoituksena oli sekä kvantitatiivisesti, että kvalitatiivisesti selvittää sairaus-spesifiä elämänlaatua tyypin 1 diabeetikoiden osalta. Lisäksi tarkoituksena oli verrata fyysisen aktiivisuuden tasoa elämänlaatumittareihin sekä hoitotasapainoon. Tähän tutkimukseen kehitettiin kyselylomake ja aineisto (N=99; mediaani-ikä 22 v; 60.6% naisia) kerättiin yhteistyössä diabetes…

Ankle-Brachial Index and Cardio-Ankle Vascular Index and their association with cardiorespiratory fitness and leisure-time physical activity in men w…

2017

Nilkka-olkavarsipainesuhteen ja verisuonten jäykkyyden yhteys hengitys- ja verenkiertoelimistön kuntoon sekä vapaa-ajan fyysiseen aktiivisuuteen tyypin 1 diabetesta sairastavilla miehillä. Johdanto. Tyypin 1 diabetesta sairastavilla valtimosairauksien riski on huomattavasti kohonnut verrattuna henkilöihin, joilla ei ole diabetesta. Fyysisen aktiivisuuden on osoitettu olevan yhteydessä matalampaan sydän- ja verisuonisairauksien riskiin, minkä takia fyysisen aktiivisuuden lisääminen voisi auttaa tyypin 1 diabeetikkojen sairastumisriskin hallitsemisessa. Tutkimuksen tarkoitus oli vertailla nilkka-olkavarsipainesuhdetta (ABI) ja valtimoiden jäykkyyttä CAVI-indeksillä mitattuna tyypin 1 diabetes…