Search results for "DIF"
showing 10 items of 16936 documents
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits
2014
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …
Valeur de l’IRM de diffusion pour caractériser les petites masses rénales (< 3cm)
2012
Objectifs: Décrire l’aspect des masses rénales (< 3cm) en imagerie de diffusion et déterminer le rôle de l’ADC pour la différentiation entre lésion maligne et bénigne. Matériels et méthodes: 47 tumeurs rénales < 3cm (23 malignes, 24 bénignes) furent explorées en IRM 3T incluant en sus du protocole habituel une séquence de diffusion (b1000). Une analyse rétrospective qualitative et quantitative (ADC) fut réalisée avec corrélation anatomopathologique et tests statistiques pour déterminer l’efficacité de la valeur d’ADC pour caractériser la lésion. Résultats: En diffusion, toutes les masses étaient hyperintenses au parenchyme sain. L’ADC moyen des CC RCC était supérieur à celui des angiomyolip…
The Effect of the Range of a Modulating Phase Mask on the Retrieval of a Complex Object from Intensity Measurements
2021
The authors have been supported by the postdoctoral project (1.1.1.2/16/I/001, 1.1.1.2/VIAA/1/16/199), the CAMART2 project (grant agreement ID 739508), the Latvian Investment and Development Agency (LIDA) project (KC-PI-2017/105), and the grant for the Latvian State Emeritus Scientists.
The effect of noise, a constant background, and bit depth on the phase retrieval of pure phase objects
2021
Acknowledgements – The authors are supported by the postdoctoral project (1.1.1.2/16/I/001; 1.1.1.2/ VIAA/1/16/199, State Education Development Agency, Republic of Latvia).
Degradation of an alkaloid pheromone from the pale-brown chafer, Phyllopertha diversa (Coleoptera: Scarabaeidae), by an insect olfactory cytochrome P…
1999
AbstractThe pale-brown chafer, Phyllopertha diversa, utilizes an unusual alkaloid, 1,3-dimethyl-2,4-(1H,3H)-quinazolinedione, as its sex pheromone. This compound is rapidly degraded in vitro by the antennal protein extracts from this scarab beetle. Demethylation at the N-1 position and hydroxylation of the aromatic ring have been identified as the major catabolic pathways. The enzyme responsible for the pheromone degradation is membrane-bound, requires NAD(P)H for activity and is sensitive to cytochrome P450 inhibitors, such as proadifen and metyrapone. The ability to metabolize this unusual pheromone was not detected in 12 species tested, indicating that the P450 system, specific to male P…
SrP3N5O: a highly condensed layer phosphate structure solved from a nanocrystal by automated electron diffraction tomography.
2011
The oxonitridophosphate SrP(3)N(5)O has been synthesized by heating a multicomponent reactant mixture that consisted of phosphoryl triamide OP(NH(2))(3), thiophosphoryl triamide SP(NH(2))(3), SrS, and NH(4)Cl enclosed in evacuated and sealed silica-glass ampoules up to 750 °C. The compound was obtained as nanocrystalline powder with needle-shaped crystallites. The crystal structure was solved ab initio on the basis of electron diffraction data by means of automated electron diffraction tomography (ADT) and verified by Rietveld refinement with X-ray powder diffraction data. SrP(3)N(5)O crystallizes in the orthorhombic space group Pnma (no. 62) with unit-cell data of a=18.331(2), b=8.086(1), …
Surfactant-Mediated Morphology and Photocatalytic Activity of α‑Ag2WO4 Material
2018
In the present work, the morphology (hexagonal rod-like vs cuboid-like) of an α-Ag2WO4 solid-state material is manipulated by a simple controlled-precipitation method, with and without the presence of the anionic surfactant sodium dodecyl sulfate (SDS), respectively, over short reaction times. Characterization techniques, such as X-ray diffraction analysis, Rietveld refinement analysis, Fourier-transform (FT) infrared spectroscopy, FT Raman spectroscopy, UV–vis spectroscopy, transmission electron microscopy (TEM), high-resolution TEM, selected area electron diffraction, energy-dispersive X-ray spectroscopy, field emission-scanning electron microscopy (FE-SEM), and photoluminescence emission…
Numerical procedures and their practical application in PV module analyses. Part III: parameters of atmospheric transparency – determining and correl…
2023
The presented article examines aspects of a PV module testing using natural sunlight in outdoor conditions. The article discusses the physical sense of indexes: atmosphere purity, diffused component content, beam clear sky index. Procedures for their determination are given in relation to both instantaneous and daily values. Their close connection with the values of solar irradiance spectral distribution such as Average Photon Energyand Useful Fractionis demonstrated, as well as their usefulness in moduletesting in outdoor conditions. Their influence on the conversion of modules made from various absorbers and various technologies is demonstrated
Motorisen oppimisen vaikeuden tunnistaminen ja tukeminen kouluympäristössä
2018
Motorisen oppimisen vaikeudella, kuten kehityksellisellä koordinaatiohäiriöllä (DCD), tarkoitetaan huomattavaa vaikeutta oppia uusia motorisia taitoja ja soveltaa jo opittuja taitoja uusiin tilanteisiin. Tämän tutkimuksen tarkoituksena oli kehittää opettajien käyttöön havainnointityökalu, joka auttaa tunnistamaan motorisen oppimisen vaikeuden esi- ja alkuopetusikäisillä lapsilla. Lisäksi tutkimus selvitti, miten opettajat voivat kouluympäristössä tukea lapsia, joilla on haasteita motorisessa oppimisessa. Tutkimus muodostui neljästä osatutkimuksesta. Ensimmäisessä tutkittiin systemaattisen kirjallisuuskatsauksen avulla maailmalla käytössä olevien havainnointilomakkeiden psykometrisiä ominais…
Il danno da prodotto difettoso ai tempi di Amazon e la proposta di direttiva sulla responsabilità del produttore
2023
A distanza di poco meno di quarant’anni dalla sua emanazione (con recepimento italiano, nella circostanza, insolitamente tempestivo) la direttiva sulla responsabilità da prodotto difettoso è sul punto di essere riscritta. La commissione europea ha presentato una nuova proposta di direttiva, con l’obiettivo dichiarato di sostituire una disciplina considerata non più in grado di fornire risposte adeguate alle esigenze di tutela dei consumatori. A veder bene, le modificazioni prospettate non stravolgono l’impostazione iniziale in chiave di «strict liability», anche se il modello statunitense da cui traeva ispirazione l’iniziativa comunitaria ha subito, nel frattempo, accentuate rivisitazioni c…