Search results for "DIR"
showing 10 items of 10242 documents
Assessment of Granger causality by nonlinear model identification: application to short-term cardiovascular variability.
2007
A method for assessing Granger causal relationships in bivariate time series, based on nonlinear autoregressive (NAR) and nonlinear autoregressive exogenous (NARX) models is presented. The method evaluates bilateral interactions between two time series by quantifying the predictability improvement (PI) of the output time series when the dynamics associated with the input time series are included, i.e., moving from NAR to NARX prediction. The NARX model identification was performed by the optimal parameter search (OPS) algorithm, and its results were compared to the least-squares method to determine the most appropriate method to be used for experimental data. The statistical significance of…
Predatory Open-Access Publishing in Anesthesiology.
2018
Predatory publishing is an exploitative fraudulent open-access publishing model that applies charges under the pretense of legitimate publishing operations without actually providing the editorial services associated with legitimate journals. The aim of this study was to analyze this phenomenon in the field of anesthesiology and related specialties (intensive care, critical and respiratory medicine, pain medicine, and emergency care). Two authors independently surveyed a freely accessible, constantly updated version of the original Beall lists of potential, possible, or probable predatory publishers and standalone journals. We identified 212 journals from 83 publishers, and the total number…
Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
2022
The diagnosis of inherited metabolic disorders is a long and tedious process. The matching of clinical data with a genomic variant in a specific metabolic pathway is an essential step, but the link between a genome and the clinical data is normally difficult, primarily for new missense variants or alterations in intron sequences. Notwithstanding, elucidation of the pathogenicity of a specific variant might be critical for an accurate diagnosis. In this study, we described a novel intronic variant c.2597 + 5G > T in the donor splice sequence of the PHKA2 gene. To investigate PHKA2 mRNA splicing, as well as the functional consequences on glycogen metabolism, we generated hepatocyte-like ce…
Mutation of the important Tyr-33 residue of chicken avidin: functional and structural consequences
2002
The strong interaction between avidin and biotin is so tight (dissociation constant 10-15M) that conditions usually sufficient for protein denaturing fail to dislodge biotin from the avidin—biotin complex. This kind of irreversible binding hinders the use of avidin in applications such as affinity purification or protein immobilization. To address this concern, we have constructed a series of mutants of the strategically positioned Tyr-33 in order to study the role of this residue in biotin binding, and to create avidin variants with more reversible ligand-binding properties. Unexpectedly, an avidin mutant in which Tyr-33 was replaced with phenylalanine (Avm-Y33F) displayed similar biotin-b…
Bitcoin e cyber self-laundering: lo sguardo sospettoso della Cassazione sull'impiego di criptovaluta
2023
In Judgment n. 27023 of 2022, the italian Supreme Court recognized the confgurability of the crime of self-money laundering in the conduct of a person who uses the proceeds of crimes committed by him to purchase bitcoin, not directly, but through the intermediation of cryptocurrency exchange companies. The Author takes the pronouncement as a starting point to probe the extent to which the culture of suspicion, with which the anti-money laundering legislation is imbued, and the stigmatization of cryptocurrency have influenced the Supreme Court's guidance, in which there emerges a strong temptation to establish a kind of automatism between the input of illicit proceeds into the bitcoin system…
Bitcoin e rivoluzione digitale internazionale. Note a margine di una sentenza della United States District Court of Columbia.
2021
This Note is about the recent recognition, by the United District Court of Columbia, of bitcoin as 'money'. The Note offers a brief insight of the decision and some reflections on the actual international digital revolution and the current threats/opportunities related to it.
Analysis of the Characteristics in the Meudon Constrained Evolution Scheme
2007
A first analysis of the characteristics associated with the evolving modes in the constraint evolution scheme proposed by the Meudon group in 2004 is presented. The system is written in a first-order hyperbolic form and a so-called generalized Dirac gauge is considered. Applications to inner boundary conditions in an excised approach to black hole evolutions are discussed.
A time evolution model for total-variation based blind deconvolution
2007
Departamento Matematica Aplicada, Universidad de Valencia, Burjassot 46100, Spain.We propose a time evolution model for total-variation based blind deconvolution consisting of two evolution equations evolv-ing the signal by means of a nonlinear scale space method and the kernel by using a diffusion equation starting from the zerosignal and a delta function respectively. A preliminary numerical test consisting of blind deconvolution of a noiseless blurredimage is presented.
Atomic Decomposition of Weighted Besov Spaces
1996
We find the atomic decomposition of functions in the weighted Besov spaces under certain factorization conditions on the weight. Introduction. After achieving the atomic decomposition of Hardy spaces (see [8,22, 33]), many of the function saces have been shown to admit similar decompositions. Let us mention the decomposition of B.M.O. (see [32, 25]), Bergman spaces (see [9, 23]), the predual of Bloch space (see [ 11]), Besov spaces (see [15, 4, 10]), Lipschitz spaces (see [18]), Triebel-Lizorkin spaces (see [16, 31]),... They are obtained by quite different methods, but there is a unified and beautiful approach to get the decomposition for most of the spaces. This is the use of a formula du…
Protocol for Low-level laser therapy in traumatic ulcer after troncular anesthesia: Case report in pediatric dentistry
2020
The aim of this study was to report a protocol of use for low-level laser therapy (LLLT) in traumatic ulcer in the lower lip after inferior alveolar nerve block anesthesia (IANBA). A 3-year-old patient, male, undergoing treatment of carious lesions was submitted to an indirect pulp capping in tooth 74 under IANBA. The procedure was completed without intercurrences, but on next day, the child presented extensive traumatic ulcer in the left lower lip, with complaint of pain. Two sequential applications with LLLT were applied in punctual mode under pressure around the lesion. After 1 week, the mother reported significant improvement. After 30 days, the lesion was fully healed. In conclusion, L…