Search results for "DISEASE BURDEN"
showing 10 items of 85 documents
Cardiovascular disease burden: Italian and global perspectives
2021
Background Cardiovascular disease (CVD) is still the leading cause of death worldwide, responsible for an estimated 17.8 million deaths globally in 2017, accounting for 31.8% of all deaths. In this review, we aim to provide an updated overview of CVD burden from an Italian and a global perspective. Methods Crude and age-standardized incidence and prevalence, as well as age-standardized mortality rate and morbidity rate (expressed as disability-adjusted life years - DALYs), of different cardiovascular conditions, derived from the Global Burden of Disease Injuries, and Risk Factors Study (GBD) 2017, were reported and compared between Italy and the world. Results Crude prevalence of CVD in Ita…
APOC-III: a Gatekeeper in Controlling Triglyceride Metabolism
2023
Abstract Purpose of Review Apolipoprotein C-III (ApoC-III) is a widely known player in triglyceride metabolism, and it has been recently recognized as a polyhedric factor which may regulate several pathways beyond lipid metabolism by influencing cardiovascular, metabolic, and neurological disease risk. This review summarizes the different functions of ApoC-III and underlines the recent findings related to its multifaceted pathophysiological role. Recent Findings The role of ApoC-III has been implicated in HDL metabolism and in the development of atherosclerosis, inflammation, and ER stress in endothelial cells. ApoC-III has been recently considered an important player in insulin resistance …
Editorial: Why do We Choose to Address Health 2020?
2013
Recommended Citation: Flahault A, Martin-Moreno JM. Why do we choose to address health 2020? Public Health Reviews. 2013;35: epub ahead of print.What can we predict for 2020? Solar and lunar eclipses? Without a doubt. Climate change? Most likely. Rising sea levels? Signs point to yes. Beyond that, however, in the world of human events, it is best to be cautious. In the field of health and medicine (or anywhere else, for that matter), no one predicted the most important discoveries of the twentieth century. Economists were no more successful in foreseeing financial or economic crises. The pundits did not forecast any of the recent wars, disruptions or even the recent Arab Spring movements-in…
Evolución de los riesgos ambientales en el contexto de la crisis económica. Informe SESPAS 2014
2014
ResumenNuestro objetivo es analizar el impacto de la crisis económica-financiera en los determinantes ambientales de la salud. La Organización Mundial de la Salud estima que entre un 13% y un 27% de la carga de enfermedad de los países podría prevenirse mejorando el medio ambiente. Los efectos son de mayor magnitud en poblaciones más vulnerables, en especial entre los más pobres. En la última década, la contaminación atmosférica exterior (el riesgo ambiental más relevante, en términos de salud, para la mayoría de los países europeos) se ha reducido moderadamente, sobre todo por las políticas europeas de reducción de emisiones y por la disminución de la actividad con la crisis económica. En …
Prospective Multinational Study of Pertussis Infection in Hospitalized Infants and Their Household Contacts
2007
Increased incidence of pertussis has been noted among infants too young to be immunized. We studied the disease burden of pertussis in pediatric intensive care units and the source of infection in several Asian, European and Latin American countries.The study was conducted in 7 countries from September 2001 to January 2004. Children1 year of age were enrolled from pediatric intensive care units (PICU) and pediatric wards if they presented with respiratory failure, apnea, bradycardia, or cough accompanied by paroxysms, vomiting, whoop or cyanosis. Household members of pertussis-positive index cases were asked to answer a questionnaire and provide diagnostic specimens.Pertussis was confirmed …
Real-world evidence from a European cohort study of patients with treatment resistant depression: Baseline patient characteristics: Patient character…
2021
Background: Treatment resistant depression (TRD; failure to respond to ≥2 treatments) affects ~20% of patients with major depressive disorder (MDD). Real-world data could help describe patient characteristics and TRD disease burden, to assess the unmet needs of TRD patients in Europe. Methods: This observational study collected data from adults with moderate to severe TRD initiating a new treatment for depression, according to local standards of care. At baseline, socio-demographic characteristics, medical history, prior and current treatments were recorded. Disease severity, health-related quality of life (HRQoL), functionality and productivity were assessed. Results: Overall, 411 eligible…
Global injury morbidity and mortality from 1990 to 2017 : results from the Global Burden of Disease Study 2017
2020
Publisher's version (útgefin grein)
Carga global, regional y nacional de neurológicas. Desórdenes, 1990-2016: un análisis sistemático para el Global Estudio de la carga de enfermedad 20…
2019
Publisher´s version (útgefin grein).
Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from th…
2020
Incluye: Correction: Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017. Inj Prev. 2020 Oct;26(Supp 1):i164. doi: 10.1136/injuryprev-2019-043296corr1. Epub 2020 Sep 28. PMID: 32989004 Background: The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjuste…
Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions
2019
Abstract Aims Ambient air pollution is a major health risk, leading to respiratory and cardiovascular mortality. A recent Global Exposure Mortality Model, based on an unmatched number of cohort studies in many countries, provides new hazard ratio functions, calling for re-evaluation of the disease burden. Accordingly, we estimated excess cardiovascular mortality attributed to air pollution in Europe. Methods and results The new hazard ratio functions have been combined with ambient air pollution exposure data to estimate the impacts in Europe and the 28 countries of the European Union (EU-28). The annual excess mortality rate from ambient air pollution in Europe is 790 000 [95% confidence i…