Search results for "DISEASES"
showing 10 items of 20537 documents
Documento de consenso de un grupo de expertos de la Sociedad Española de Arteriosclerosis (SEA) sobre el uso clínico de la resonancia magnética nucle…
2020
Resumen La evaluacion y prevencion del riesgo cardiovascular (RCV) que persiste en los pacientes con dislipidemia a pesar del tratamiento y de haber alcanzado los objetivos especificos de la concentracion plasmatica de colesterol unido a lipoproteinas de baja densidad (c-LDL) es un reto clinico en la actualidad, y sugiere que los biomarcadores lipidicos convencionales resultan insuficientes para una evaluacion precisa del RCV. Mas alla de su contenido lipidico, existen otras caracteristicas propias de las particulas lipoproteicas que determinan su potencial aterogenico y su influencia en el RCV. Sin embargo, dichas caracteristicas adicionales no pueden ser analizadas por las tecnicas utiliz…
The montrachet study
2016
National audience; Summary The Montrachet Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) is a population‐based derived from the 3C Study performed in Dijon. In 2009–2011, 1153 participants from the 3 Cities Study, aged 75 years or more, had an initial eye examination. Apart from the old age of this population, the main interest is that information on cardiovascular and neurologic diseases and a large comprehensive database (blood samples, genetic testing, cognitive tests, MRI) were available. Our first results showed us that despite the high prevalence of self‐reported eye diseases in this elderly population, visual impairment was low and increased with age. Thes…
10-Year Journey Through Brain Gliomas: Case Report
2020
Abstract We present the case of a 28-year-old doctor who was diagnosed in 2009 with grade II oligodendroglioma. In the next 10 years he underwent 4 surgeries, passing in turn through 3 different types of cerebral gliomas: grade II oligodendroglioma, grade III oligoastrocytoma and IDH Wild-Type glioblastoma. In the spirit of the surgical resection limited by the preservation of the function, he was able to practice his medical profession until the last months of his life. Life expectancy at the time of diagnosis complied with all the statistical data. Although the etiology, pathophysiology and treatment of cerebral gliomas is still full of unknowns, knowing our limits we can provide a good q…
Biological and physical modification of carbonate system parameters along the salinity gradient in shallow hypersaline solar salterns in Trapani, Ita…
2017
Abstract We investigated changes in the chemical characteristics of evaporating seawater under the influence of microbial activity by conducting geochemical analyses of the brines and evaporite sediments collected from solar salterns in Trapani, Italy. The microbial activity had a substantial effect on the carbonate system parameters. Dissolved inorganic carbon (DIC) was substantially removed from the brine during the course of evaporation from the seawater to the point where calcium carbonate precipitates, with an accompanying decrease in its carbon isotopic composition (δ 13 C DIC ) to as low as −10.6‰. Although the removal of DIC was due to calcium carbonate precipitation, photosynthesis…
Comments on "Dental lessons from past to present: Ultrastructure and composition of teeth from plesiosaurs, dinosaurs, extinct and recent sharks" by …
2016
The paper mentioned in the title suggests that several groups of extinct vertebrates used fluoroapatite as a tooth mineral in dentine and enamel when alive; its authors posit that this tooth mineralization drastically changed in all these lineages at some point during their evolution, leading to the use of hydroxyapatite as an alternative primary tooth mineral, because of hitherto unconsidered environmental changes. These conclusions are based on their finding high fluoride levels (i.e. fluoroapatite) in the dentine of fossilised shark teeth as well as in both the dentine and enamel of plesiosaurs, mosasaurs, and dinosaurs, which is in sharp contrast to recent teeth (which contain almost no…
Patología vascular: ¿causa o efecto en la enfermedad de Alzheimer?
2018
Resumen: Introducción: La enfermedad de Alzheimer (EA) es la principal enfermedad neurodegenerativa cortical. Su incidencia aumenta con la edad, lo que provoca importantes problemas médicos, sociales y económicos, especialmente en países con población envejecida. Objetivo: El objetivo de esta revisión es poner de manifiesto las evidencias que existen sobre el modo en que la disfunción vascular puede contribuir al deterioro cognitivo en la EA, así como las posibilidades terapéuticas que de ello podrían derivarse. Desarrollo: La hipótesis vascular ha surgido como alternativa a la hipótesis de la cascada amiloide como explicación de la fisiopatología de la EA. Esta hipótesis sitúa en los vasos…
La alteración de la mielina en la enfermedad de Alexander
2018
Resumen: Introducción: La enfermedad de Alexander (AxD) es una leucodistrofia. Su base patológica, junto a la pérdida de mielina, es la aparición de los cuerpos de Rosenthal, que son inclusiones citoplasmáticas en células astrocitarias. Mutaciones en el gen que codifica la GFAP se han identificado como una base genética para AxD. Sin embargo, no se conoce el mecanismo por el cual estas variantes producen la enfermedad. Desarrollo: La hipótesis más extendida es que AxD se desarrolla por un mecanismo por ganancia de función debido al incremento de GFAP. Sin embargo, este mecanismo no explica la pérdida mielínica, dado que los modelos experimentales que expresan GFAP normal o mutada no generan…
Update on the management of intra-abdominal Candida infections.
2017
Extensive osteonecrosis of the maxilla caused by bisphosphonates: Report of a rare case
2019
Bisphosphonates are drugs indicated for the treatment of bone metabolic diseases or malignant hypercalcemia. They are generally well-tolerated drugs, however, recent reports have described osteonecrosis of the jaw bones as a potentially serious complication related to the long-term use of these drugs. We report a case of severe osteonecrosis in a 52-years-old white woman that was taking bisphosphonates (zoledronic acid and alendronate) for the management of osteoporosis. Following a long exposure to these drugs and after being subjected to multiples exodontias, developed bisphosphonate-related osteonecrosis of the jaw compromising the whole maxilla and that extended toward the base of skull…
Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Cha…
2021
Hematopoietic cell (HC) transplantation (HCT) is the last resort to cure hematopoietic malignancies that are refractory to standard therapies. Hematoablative treatment aims at wiping out tumor cells as completely as possible to avoid leukemia/lymphoma relapse. This treatment inevitably co-depletes cells of hematopoietic cell lineages, including differentiated cells that constitute the immune system. HCT reconstitutes hematopoiesis and thus, eventually, also antiviral effector cells. In cases of an unrelated donor, that is, in allogeneic HCT, HLA-matching is performed to minimize the risk of graft-versus-host reaction and disease (GvHR/D), but a mismatch in minor histocompatibility antigens …