Search results for "DISRUPTION"
showing 10 items of 52 documents
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
2018
© 2018 Elsevier Inc.
Glia talk back.
2014
This study shows that the activity of neurons can trigger shedding of a protein, NG2, from the surface of oligodendrocyte precursor cells; this protein in turn modulates synaptic transmission, revealing a two-way conversation between neurons and glia.
Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?
2014
International audience; Brain-derived neurotrophic factor (BDNF) through TrkB activation is central for brain functioning. Since the demonstration that plasmin is able to process pro-BDNF to mature BDNF and that these two forms have opposite effects on neuronal survival and plasticity, a particular attention has been paid to the link between tissue plasminogen activator (tPA)/plasmin system and BDNF metabolism. However, t-PA via its action on different N-methyl-D-aspartate (NMDA) receptor subunits is also considered as a neuromodulator of glutamatergic transmission. In this context, the aim of our study was to investigate the effect of recombinant (r)t-PA administration on brain BDNF metabo…
ASTROCHRONOLOGY OF LATE MIDDLE MIOCENE MEDITERRANEAN SECTIONS
2004
Fire disturbance disrupts co-occurrence patterns of terrestrial vertebrates in Mediterranean woodlands
2006
Aim This paper uses null model analysis to explore the pattern of species co-occurrence of terrestrial vertebrate fauna in fire-prone, mixed evergreen oak woodlands. Location The Erico–Quercion ilicis of the Mediterranean belt (50–800 m a.s.l.) in the Madonie mountain range, a regional park in northern Sicily (37°50′ N, 14°05′ E), Italy. Methods The stratified sampling of vertebrates in a secondary succession of recent burned areas (BA, 1–2 years old), intermediate burned areas (INT, 4–10 years old) and ancient burned areas (CNB, > 50 years old), plus forest fragments left within burned areas (FF, 1–2 years old) permitted the comparison of patterns of species co-occurrence using a set of…
Molecular topology as novel strategy for discovery of drugs with aβ lowering and anti-aggregation dual activities for Alzheimer's disease.
2014
Background and Purpose: In this study, we demonstrate the use of Molecular topology (MT) in an Alzheimer's disease (AD) drug discovery program. MT uses and expands upon the principles governing the molecular connectivity theory of numerically characterizing molecular structures, in the present case, active anti-AD drugs/agents, using topological descriptors to build models. Topological characterization has been shown to embody sufficient molecular information to provide strong correlation to therapeutic efficacy. Experimental Approach: We used MT to include multiple bioactive properties that allows for the identification of multifunctional single agent compounds, in this case, the dual func…
Shallow-marine carbonates of the tropical-temperature transition zone: effects of hinterland climate and basin physiography (late Miocene, Crete, Gre…
2006
Numerical simulations of the jetted tidal disruption event Swift J1644+57
2016
In this work we focus on the technical details of the numerical simulations of the non- thermal transient Swift J1644+57, whose emission is probably produced by a two-component jet powered by a tidal disruption event. In this context we provide details of the coupling between the relativistic hydrodynamic simulations and the radiative transfer code. First, we consider the technical demands of one-dimensional simulations of a fast relativistic jet, and show to what extent (for the same physical parameters of the model) do the computed light curves depend on the numerical parameters of the different codes employed. In the second part we explain the difficulties of computing light curves from …
Radio afterglow of the jetted tidal disruption event Swift J1644+57
2012
The recent transient event Swift J1644+57 has been interpreted as resulting from a relativistic outflow, powered by the accretion of a tidally disrupted star onto a supermassive black hole. This discovery of a new class of relativistic transients opens new windows into the study of tidal disruption events (TDEs) and offers a unique probe of the physics of relativistic jet formation and the conditions in the centers of distant quiescent galaxies. Unlike the rapidly-varying γ/X-ray emission from Swift J1644+57, the radio emission varies more slowly and is well modeled as synchrotron radiation from the shock interaction between the jet and the gaseous circumnuclear medium (CNM). Early after th…
Climate Change, Uncertainty and Ethical Superstorms
2021
I argue that one of the most urgent tasks of geoethics is how to deal with climate change in a just and equitable way. At worst, our current path could lead to multi-metre sea-level rise, increases in storms and climate extremes, causing devastating social disruption and economic consequences. I present some alternatives on how to handle this alarming prospect, arguing that we cannot condense our decision-making on climate change into numerical calculations, but should instead make ethical judgements. The commonly used expected utility maximation can be considered a gamble on future generations’ expense for the benefit of the current ones. Thus, from a Rawlsian perspective, we will instead …