Search results for "DM"

Therapeutic Potential of AntagomiR-23b for Treating Myotonic Dystrophy

2020

Myotonic dystrophy type 1 (DM1) is a chronically debilitating, rare genetic disease that originates from an expansion of a noncoding CTG repeat in the dystrophia myotonica protein kinase (DMPK) gene. The expansion becomes pathogenic when DMPK transcripts contain 50 or more repetitions due to the sequestration of the muscleblind-like (MBNL) family of proteins. Depletion of MBNLs causes alterations in splicing patterns in transcripts that contribute to clinical symptoms such as myotonia and muscle weakness and wasting. We previously found that microRNA (miR)-23b directly regulates MBNL1 in DM1 myoblasts and mice and that antisense technology (“antagomiRs”) blocking this microRNA (miRNA) boost…

OSAnalyzer: A Bioinformatics Tool for the Analysis of Gene Polymorphisms Enriched with Clinical Outcomes.

2016

Background: The identification of biomarkers for the estimation of cancer patients’ survival is a crucial problem in modern oncology. Recently, the Affymetrix DMET (Drug Metabolizing Enzymes and Transporters) microarray platform has offered the possibility to determine the ADME (absorption, distribution, metabolism, and excretion) gene variants of a patient and to correlate them with drug-dependent adverse events. Therefore, the analysis of survival distribution of patients starting from their profile obtained using DMET data may reveal important information to clinicians about possible correlations among drug response, survival rate, and gene variants. Methods: In order to provide support …

The Role of p53 Signaling in Colorectal Cancer.

2021

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates diverse cellular responses to protect against cancer development. Deactivating p53 signaling either by altering p53 regulators or by p53 mutations occurs frequently in human colorectal carcinoma (CRC). Forty-three percent of CRCs harbor p53 mutations that reduce wild-type p53 tumor suppressor activity and often provide neo-morphic functions, which contribute to tumorigenesis. In this review, we summarize wild-type p53 signaling, how it can be deregulated in CRC, and the functional and phenotypical effects of p53 mutations. We also discuss current therapeutic strategies of targeting p53. Abstract The tra…

Functional test measures as risk indicators for low back pain among fixed-wing military pilots.

2015

Purpose The purpose of this study was to find out the risk value of functional fitness test (FFT) results for low back pain (LBP) among fixed-wing military pilots. Methods A total of 104 male military pilots were recruited for this study. The study was conducted with a self-administered questionnaire and FFT. The functional tests were performed in the beginning of study (baseline). The questionnaire was carried out at the baseline and 5 years later. Results The isometric low back endurance test result was associated with physical activity-related LBP experienced 5 years later. Demographic information was not associated with LBP. The prevalence of overall LBP was 71% and the flight-related L…

Mercury, lead and cadmium concentrations in Talpa occidentalis and in their digeneans of the genus Ityogonimus

2019

Many parasites living in aquatic ecosystems are useful indicators of environmental health. On the other hand, information is scarcer with respect to the use of helminth parasites of vertebrates living in terrestrial ecosystems as monitoring tools for toxic element environmental pollution. The present study evaluates the suitability of the model Talpa occidentalis/Ityogonimus spp. as a bioindicator system for mercury (Hg), lead (Pb) and cadmium (Cd) contamination in agricultural soils from Asturias (Spain). Kidney and liver samples collected from T. occidentalis specimens (n = 36) and Ityogonimus spp. samples collected from 14 infected hosts were analyzed by ICP-MS. The highest mean levels o…

Gastrocriticism: pentru o reinterpretare a poeziei lui Emil Brumaru

2019

Abstract The aim of this essay is to offer a gastrocritical analysis of Emil Brumaru's poetry, taking into consideration the symbolism of fruits, vegetables, dairy products, spices and food in general. The four main parts of the essay are based on the sensuality of the fruits, on the memories brought up by food, on dreams stirred up by spices and on the autochtonous place described by the traditional "zacusca". These, all together, will prove the fact that the gastronomical references in Brumaru's poetry are full of connotations and this is what we will try to identify by the interdisciplinar approach.

2021

Scholarly journals are often blamed for a gender gap in publication rates, but it is unclear whether peer review and editorial processes contribute to it. This article examines gender bias in peer review with data for 145 journals in various fields of research, including about 1.7 million authors and 740,000 referees. We reconstructed three possible sources of bias, i.e., the editorial selection of referees, referee recommendations, and editorial decisions, and examined all their possible relationships. Results showed that manuscripts written by women as solo authors or coauthored by women were treated even more favorably by referees and editors. Although there were some differences between…

Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power

2011

A major difficulty in the analysis of complex biological systems is dealing with the low signal-to-noise inherent to nearly all large biological datasets. We discuss powerful bioinformatic concepts for boosting signal-to-noise through external knowledge incorporated in processing units we call filters and integrators. These concepts are illustrated in four landmark studies that have provided model implementations of filters, integrators, or both.

Discursive framing and organizational venues: mechanisms of artificial intelligence policy adoption

2021

The purpose of this article is twofold: to theoretically assess ideational and organizational explanatory factors in the adoption of artificial intelligence policies; and to examine the extent to which the European Union has managed to facilitate a coordinated artificial intelligence policy in the Nordic countries. The study utilizes a mixed-methods approach based on systematic web searching, systematic policy document analysis and key informant semi-structured interviews. The study finds that the European Union has utilized framing-based strategies to set an agenda for a coordinated European artificial intelligence policy. Moreover, the strategy has affected member-state artificial intell…

Health-related messages about physical activity promotion: an analysis of photographs on social networking sites of universities

2016

ABSTRACTThe main aim of this study was to examine how different physical activity domains are represented on the official social media sites of Spanish universities, through a content analysis of the photographs. Our results show that the representation of different physical activity domains is not balanced. While the analysed images do promote a message of gender equality in sedentary and leisure time physical activity behaviour, pictures illustrating active commuting and disabled groups were under-represented. We conclude that Internet-based physical activity promotion in university settings must to be guided by the principles of ‘health-promoting universities’ in the sense of promoting a…