Search results for "DM"
showing 10 items of 8932 documents
Unpacking Mundaneness : A novel conceptual framework for universities and regional engagement
2022
In this chapter, we debate the current view on university-regional engagements and suggest a renewed theoretical framework based on four main elements – macro, meso, micro dimensions, as well as a meta-dimension of temporality that cuts across all levels. The macro environment is typically defined as pertaining to public policies, culture, laws, and economy, while the meso environment includes links between the macro (societal) forces and the micro (agents) level through intermediate institutions and structures and is characterized by the processes and mechanisms of interaction of different actors. The micro level is about agency – organizations or individuals/groups within organizations – …
Лифляндская губернская подготовительная комиссія, 1906 г. [Лифляндская губернская подготовительная комиссия, 1906 г.]
1906
Содержание: Журналы заседаний Лифляндской губернской подготовительной комиссии (№ 1-13) по делам земского самоуправления, по учебной части, по делам церковного управления, по аграрным вопросам, о реорганизации волостного самоуправления, по судебной части. Список членов Лифл. губернской подготовительной комиссии. Перечен вопросов, внесенных на обсуждение Лифл. подготовительной комисси и другие материалы.
Effects of an incremental maximal endurance exercise stress-induced cortisol on cognitive performance
2019
Exercise; Cognitive functions; Cortisol Ejercicio físico; Funciones cognitivas; Cortisol Exercici físic; Funcions cognitives; Cortisol Objectives: It can be hypothesized that cognitive performance decreases after fatigue protocol when it coincides with the maximum peak of cortisol. The first aim of this study was to elucidate the effects of a single bout of high intensity exercise on behavioural (i.e., attention and memory) and physiological (i.e., salivary cortisol) responses. The second objective was to evaluate the effect of the performance of the cognitive tasks on cortisol levels. Methods: Thirty-four physically active men (at least 5 days/week of physical activity practice) 38.11 (1.5…
El reconocimiento como fundamento de una ética de la función pública. Un marco para su aplicación en organizaciones públicas.
2013
La tesis propone que el paradigma filosófico del reconocimiento recíproco es el más adecuado para fundamentar una ética aplicada a la función pública. Tras aplicar el método de ética aplicada como hermenéutica crítica, identifica los principales contenidos normativos de una ética de la función pública en los discursos y prácticas en los que actualmente se manifiesta esta ética. Luego, reconstruye parte del itinerario filosófico del concepto de reconocimiento recíproco para comprender las relaciones entre administradores y admionistrados como relaciones de reconocimiento. Finalmente, la tesis explora cómo desde este enfoque es posible profundizar la comprensión y proponer mejoras para la apl…
Vaccinium macrocarpon (Cranberry)-Based Dietary Supplements: Variation in Mass Uniformity, Proanthocyanidin Dosage and Anthocyanin Profile Demonstrat…
2020
Vaccinium macrocarpon (syn. American Cranberry) is employed in dietary supplements (DS) with the aim to improve urinary tract well-being. This property is linked to the antiadhesion-activity of proanthocyanidins (PACs) against uropathogenic-bacteria. However, the current European legislation has been criticized for being weak and ineffective. Indeed, recent scientific works report mislabeled, contaminated, and adulterated supplements containing dangerous or unknown compounds, or sold at toxic doses. In this work, we analysed 24 DS that claim to contain cranberry, and to have a specific dosage of PACs. Our tests included the control of the good manufacturing practice according to the Europea…
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Considering syntrophic acetate oxidation and ionic strength improves the performance of models for food waste anaerobic digestion.
2021
Current mechanistic anaerobic digestion (AD) models cannot accurately represent the underlying processes occurring during food waste (FW) AD. This work presents an update of the Anaerobic Digestion Model no. 1 (ADM1) to provide accurate estimations of free ammonia concentrations and related inhibition thresholds, and model syntrophic acetate oxidation as acetate-consuming pathway. A modified Davies equation predicted NH3 concentrations and pH more accurately, and better estimated associated inhibitory limits. Sensitivity analysis results showed the importance of accurate disintegration kinetics and volumetric mass transfer coefficients, as well as volatile fatty acids (VFAs) and hydrogen up…
Sprint and endurance training in relation to redox and inflammatory status and biomarkers of aging in master athletes
2020
Purpose Studies have shown a positive influence of intense athletic training on several biomarkers of aging, but it remains unclear whether this influence is dependent of exercise-training-mode. This study compared redox balance, cytokine levels and biomarkers of aging between master sprinters and endurance athletes, as well as in young and middle-aged individuals as controls. Methods Participants were male master sprinters (SA, 50±8.9yrs; n=13) and endurance runners (EA, 53±8.2yrs; n=18) with remarkable athletic experience (∼25yrs of practice), besides untrained young (YC, 22.7±3.9yrs; n=17) and age-matched controls (MC, 45.5±9.8yrs; n=12). Anamnesis, anthropometrics, biomarkers of aging, …
Zasada praworządności wyznacznikiem kontroli działań administracji publicznej realizowanej przez prokuratora w ramach postępowania administracyjnego
2018
Opus iustitiae PAX – the properly shaped dimension of justice is a guarantee of peaceful – not based on a conflict and violence – relations between citizens and the state. These words fully reflect the leading thought of this study. It is the concern for a good law and a state governed by the rule of law, which lies at the foundation of actions taken within the scope of legal means by the Prosecutor’s Office that – as the “custodian of law” – is entitled to in the sphere of control over administration. Administrative courts execute justice as a separate part of judicial power. Justice and law are conditions for an effective state, good governance and social peace, which have accompanied us …
The European Regional Convergence Process, 1980-1995: Do Spatial Regimes and Spatial Dependence Matter?
2002
International audience; The authors show that spatial dependence and spatial heterogeneity matter in the estimation of the ß-convergence process among 138 European regions over the 1980 to 1995 period. Using spatial econometrics tools, the authors detect both spatial dependence and spatial heterogeneity in the form of structural instability across spatial convergence clubs. The estimation of the appropriate spatial regimes spatial error model shows that the convergence process is different across regimes. The authors also estimate a strongly significant spatial spillover effect: the average growth rate of per capita GDP of a given region is positively affected by the average growth rate of …