Search results for "DM"
showing 10 items of 8932 documents
La desamortización y enajenación del dominio de Sueca a finales del antiguo régimen: la presencia de Godoy como duque y señor de Sueca
2010
La concesión del ducado de Sueca a Manuel Godoy y la adquisición, mediante pública subasta del término y las pertenencias de esta villa, provocó importantes cambios en la jurisdicción y administración de la anterior posesión de la Orden de Montesa. La modificación en las condiciones de la compra, confirieron al Príncipe de la Paz los mismos privilegios de los que disfrutaba el Rey como Gran Maestre y Administrador Perpetuo, lo que acabó generando tensiones con los vecinos, terratenientes y el propio Ayuntamiento. The granting of the Duchy of Sueca to Manuel Godoy and the acquisition by auction of the territory and the belongings of this town, led to significant changes in the jurisdiction a…
Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transpo…
2021
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, intestinal motility, and transit and drug properties under fed and fasting conditions (Paixao, P. et al. Mol. Pharm. 2018 and Bermejo, et al. M. Mol. Pharm. 2018). The dissolution of an ionizable drug may benefit from manipulating in vivo variables such as the environmental pH using pH-modifying agents incorporated into the dosage form. A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability,…
Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro ex…
2014
Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate. Three poorly-permeable drugs (atenolol, metformin hydrochloride, and furosemide) exhibiting negative food effect, and one highly-soluble and highly-permeable (metoprolol tartrate), serving as a negative control, were selected for the study. In vitro and in silico tools were used to evaluate the influence of media viscosity on drug bioperformance under fasted and fed conditions. The obtained results demonstrated that increased medium viscosity in the presence…
New prospective in treatment of Parkinson's disease: Studies on permeation of ropinirole through buccal mucosa
2012
The aptitude of ropinirole to permeate the buccal tissue was tested using porcine mucosa mounted on Franz-type diffusion cells as ex vivo model. Drug permeation was also evaluated in presence of various penetration enhancers and in iontophoretic conditions. Ropinirole, widely used in treatment of motor fluctuations of Parkinson's disease, passes the buccal mucosa. Flux and permeability coefficient values suggested that the membrane does not appear a limiting step to the drug absorption. Nevertheless, an initial lag time is observed but the input rate can be modulated by permeation enhancement using limonene or by application of electric fields. Absorption improvement was accompanied by the …
Micellar liquid chromatography for prediction of drug transport.
2000
Abstract The vast majority of well absorbed drugs are transported passively across the cell membranes. Physicochemical descriptors of drug molecules that are believed to influence transcellular transport are routinely used to predict drug absorption by means of complex mathematical models. In this paper, a new in vitro method, based on the retention data in micellar liquid chromatography (MLC), is validated for the prediction of passive drug absorption. The retention of a heterogeneous drugs set in MLC using Brij 35 as surfactant in the mobile phase is compared with the retention data reported in literature obtained in red cell membrane lipid liposomes, human red cell membranes vesicles (ve…
Lung on a Chip Development from Off-Stoichiometry Thiol–Ene Polymer
2021
Institute of Solid-State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2. Finally, we would like to thank Biol. Kaspars Tars from Latvian Biomedical research and study center for giving us the opportunity to participate in this consortium and contribute to Latvian scientists’ effort in response to the COVID-19 pandemic.
Estimation of ADME Properties in Drug Discovery: Predicting Caco-2 Cell Permeability Using Atom-Based Stochastic and Non-stochastic Linear Indices
2007
The in vitro determination of the permeability through cultured Caco-2 cells is the most often-used in vitro model for drug absorption. In this report, we use the largest data set of measured P(Caco-2), consisting of 157 structurally diverse compounds. Linear discriminant analysis (LDA) was used to obtain quantitative models that discriminate higher absorption compounds from those with moderate-poorer absorption. The best LDA model has an accuracy of 90.58% and 84.21% for training and test set. The percentage of good correlation, in the virtual screening of 241 drugs with the reported values of the percentage of human intestinal absorption (HIA), was greater than 81%. In addition, multiple …
Absorption of Drugs after Oral Administration
2007
After oral administration, drugs must be absorbed through the gastrointestinal tract to achieve the systemic circulation and exert their pharmacological effects. The successful formulation of an optimized oral drug delivery system requires a detailed consideration and a good understanding of the intestinal absorption process, its possibilities and limitations. This article gives an overview and update on the concepts, possibilities, and limitations of drug absorption after oral administration. Keywords: oral administration; drug absorption; oral drug delivery system; gastrointestinal tract; intestinal absorption
LATIN AMERICA AND ABYA YALA IN TEACHING SPANISH HISTORY: THE "DISCOVERY", THE CONQUEST AND CONTROVERSIES OF THE BLACK LEGEND
2019
RESUMO O trabalho explicita as representações contemporâneas da História da América no ensino de História na Espanha. Explicita e problematiza as configurações textuais e iconográficas que pretendem ensinar uma história do “descobrimento”, da conquista e da colonização da América. Usou-se a metodologia da pesquisa bibliográfica e de campo, com técnica de fichamento e observações analíticas de obras historiográficas contemporâneas, livros didáticos e lugares de memória (museus e monumentos históricos). Em relação aos manuais didáticos, foram selecionados e analisados 18 livros de ensino de História editados por seis editoras no período de 2000 a 2015. Analisou-se a história do “descobrimento…
Characterizing smart tracking-based self-service technologies (STB SSTs) and their acceptance antecedents : a systematic literature review
2022
This paper introduces smart tracking-based self-service technologies (STB SSTs) as a new category of self-service. STB SSTs allow brand customers to voluntarily perform feedback-seeking that targets their brand-related consumption occurring in a connected environment, provided they consent to share private data with their brand. Despite an increasing deployment, this category of self-service is not well defined in the literature. In addition, we have little understanding of consumer motivations to use these technologies. The present work attempts to fill these gaps by performing an interpretive literature review. Our literaturereview highlights the necessity to distinguish between core and …