Search results for "DM"
showing 10 items of 8932 documents
p38 MAPK in cadmium-treated MDA-MB231 breast cancer cells
2008
Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neurob…
2012
The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mecha- nisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivation as an attractive perspective for neuroblastoma treat- ment. In addition to its role in tumorigenesis, MYCN sensitizes untransformed and cancer cells to apoptosis. This is associated to a fine modulation of the MDM2-p53 pathway Indeed MYCN induces p53 and MDM2 transcription, and, by evoking a DNA damage response (DDR), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Prote…
Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuat…
2021
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis. In this study, we utilized a rapid synthetic route to synthesize two novel hybrid spirooxindole-based p53-MDM2 inhibitors endowed with Bcl2 signaling attenuation. The adducts mimic the thematic features of the chemically stable potent spiro [3H-indole-3,2′-pyrrolidin]-2(1H)-ones p53-MDM2 inhibitors, while installing a pyrrole ring via a carbonyl spacer inspired by the natural marine or synthetic products that efficiently inhibit Bcl2 family functions. A chemical insight into the two synthesized…
Pagaidu noregulējuma piemērošanas problemātika publisko iepirkumu lietās
2021
Bakalaura darba mērķis ir identificēt pagaidu noregulējuma piemērošanas problemātiku publisko iepirkumu strīdos. Pētījumā secināts, ka efektīvu pagaidu noregulējuma piemērošanu liedz lūguma izskatīšanai paredzētais termiņš, likumā noteikta aizlieguma neesamība šajā laikposmā noslēgt iepirkuma līgumu, tiesas pienākums uzklausīt trešās personas, nepietiekama subjektīvās nepieciešamības pamatošana u.c. Konstatēts, ka iepirkuma līguma noslēgšanas un spēkā esības obligāts priekšnoteikums ir spēkā esošs Iepirkumu uzraudzības biroja lēmums, kas pēc iepirkuma līguma noslēgšanas turpina radīt aktuālas tiesiskās sekas. Pētījumā identificēto problēmu novēršanai tiek piedāvāts saīsināt laika periodu, k…
Promotions and Earnings – Gender or Merit? Evidence from Longitudinal Personnel Data
2017
This study examines the determinants of promotions, performance evaluations and earnings using unique longitudinal data from the personnel records of a large university. The study focuses on the role of gender in remuneration using, first, information on the complexity ratings of job tasks to define promotions on job ladders and, second, information on objective individual productivity. The study finds that individual research productivity was an important determinant of promotions and earnings. The results indicate that gender has no effect on the probability of being promoted, conditional on productivity, nor does it play a role in the performance evaluation of employees. Furthermore, the…
Jak historia odkłada się w pamięci, jak pamięć odkłada się w języku
2019
Tematem artykułu jest zakreślenie ram pola badawczego tworzonego przez trzy tytułowe pojęcia: historia, pamięć, język. Ponieważ każde z nich jest wieloznaczne, a na dodatek w różnych sytuacjach odnoszone są do różnych porządków ontologicznych (do rzeczywistości pozajęzykowej i do rzeczywistości tekstowej, narracyjnej), autor stara się doprecyzować znaczenia odnośnych wyrazów i pokazać złożone relacje, jakie występują zarówno między poszczególnymi znaczeniami każdego z wyrazów oddzielnie (a więc pomiędzy „historią1” i „historią2” z jednej strony oraz między „pamięcią1” i „pamięcią2” – z drugiej), jak też, w układzie „horyzontalnym”, między „historią1” i „pamięcią1” oraz między „historią2” a …
The Role of Parliament in Sustainable Development Goals: A Case Study of Southeast Asia in International Parliamentary Forums
2021
Parliament has its role in supporting Sustainable Development Goals (SDG). SDG number 16 on peace, justice, and strong institution states one indicator of a legislative institution (for “responsive, inclusive, participatory and representative”, that the Inter-Parliamentary Union (IPU) commits to achieve. However, parliament must support the government in achieving all SDG programs as stated in Agenda 2030. What is the role of parliament in this and how to achieve it? This paper aims to show that the role of parliament in SDG is beyond the traditional legislative role of legislating, budgeting and overseeing the government, but more on representing people, meaning channeling people’s voice a…
Student employment in France: Hindrance rather than help for higher educational success?
2021
International audience; In this study, we examine how student employment impacts higher educational trajectories in France. Focussing on undergraduates’ educational outcomes, we show the consequences of different intensities and levels of recurrence of student employment on perseverance in higher education. We use data from a nationally representative four-year longitudinal survey, descriptive analysis and logistic regression are performed to control for student characteristics. Our results suggest that student employment, especially when intensive and during periods of exams, increases exam failure. When it is recurrent over time, student employment often leads to university dropout. Furth…
WEB 2.0 ET MUSÉES Les nouveaux visages du visiteur
2012
WEB 2.0AND MUSEUMS: THE NEW EACES OF THE VISITOR The increasing integration of techniques from Web 2.0 by the museums illustrates the profound changes that these structures have realized in building their relationship with the audience. The use of these devices, based on a logic of participation, leads to involve the visitor, traditionally rather kept at a distance, on all stages of the implemeritation of the mUseum offered on Internet. Through a careful examinât icin of sites arid features offered by the museal structures, different roles now devolved to the public have been identified. The emergence of these new "faces" of the visitor comes to question, in the longer-term, about the ident…
USING THE ENVIRONMENTAL MANAGEMENT SYSTEM (EMS) TO CONTROL THE IMPLEMENTATION AND EMERGENCE OF GREEN STRATEGIES.
2009
To respond to the ecological challenges of the new century and their Environmental and Social Responsability, more and more companies adopt the Environmental Management System (EMS). The objective of this thesis is to analyze how this management system is used in French companies for implement their ''intended" green strategies and to explore the new green strategies. To answer this problematic, we mobilized two theoretical frameworks during this research: the New Institutionalism in Organizational Analysis (DiMaggio and Powell, 1983, 1991 and Hasselbladh Kallinikos, 2000) and Levers of control model (Simons, 1995). Then, our research methodology is composed of three phases succeeding: an e…