Search results for "DMAPT"

The cytotoxic effect exerted by parthenolide and DMAPT on breast cancer stem-like cells

2015

Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma associated with a high rate of recidivism. It is known that a small proportion of tumour cells, termed cancer stem cells (CSCs), is responsible for tumour formation, progression and recurrence. The sesquiterpene lactone parthenolide (PN) was identified as the first small molecule capable of killing CSCs.1 Previously we have shown2 that PN and its soluble analogue DMAPT induce a strong cytotoxic effect in MDA-MB231 cells, the most studied line of TNBCs. In the present research we investigated about the effects exerted by both PN and DMAPT on breast cancer stem-like cells derived from three lines of TNBCs (MDA-MB2…

Evaluation of the in vitro and in vivo antineoplastic effects of Parthenolide on MDA-MB231 breast cancer cells

2012

Triple-negative breast cancer refers to an aggressive subtype of breast cancer in which the tumor cells lack receptors for estrogen, progesterone and the HER2 protein on their surfaces. This type of breast cancer does not respond to treatments such as hormone therapy, like tamoxifen and aromatase inhibitors, or drugs that target HER2, like Herceptin. It is important, therefore, the identification of new selective drugs for the treatment of these tumors. Parthenolide (PN), a sesquiterpene lactone extracted from the medical plant Tanacetum parthenium, exerts anticancer activity on several tumor cell lines in culture, acting through diverse molecular mechanisms. Our previous studies have shown…

Combined treatment of caffeic acid and DMAPT induces AMPK dependent death in MDA-MB231 cells

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

2022

Due to its chemical properties and multiple molecular effects on different tumor cell types, the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with significant potential in cancer therapy. PN has been shown to induce either classic apoptosis or alternative caspase-independent forms of cell death in many tumor models. The therapeutical potential of PN has been increased by chemical design and synthesis of more soluble analogues including dimethylaminoparthenolide (DMAPT). This review focuses on the molecular mechanisms of both PN and analogues action in tumor models, highlighting their effects on gene expression, signal transduction and execution of different ty…

Valutazione degli effetti del dimetilamino-partenolide (DMAPT) in vivo in xenotrapianti di cellule di carcinoma mammario MDA-MB231

2014

Obiettivo degli studi condotti in questa tesi è stato quello di valutare l’efficacia del Partenolide in vivo in xenotrapianti ottenuti da cellule di carcinoma mammario triplo negativo MDA-MB231 in topi immunodeficienti. Lo studio è stato condotto impiegando il dimetilamino-partenolide (DMAPT), un analogo del partenolide più solubile. I risultati delle ricerche hanno dimostrato che la somministrazione di DMAPT a topi immunodeficienti portatori di xenotrapianti di cellule MDA-MB231 determina una significativa inibizione della crescita dei tumori e un incremento della sopravvivenza degli animali. Analisi immunoistochimiche condotte su preparati istologici ottenuti dai tumori hanno anche dimost…