Search results for "DMR"
showing 10 items of 12 documents
Transcriptome Analysis Identifies Doublesex and Mab-3 Related Transcription Factor (DMRT3) in Nasal Polyp Epithelial Cells of Patients Suffering from…
2021
Background: Aspirin-exacerbated respiratory disease (AERD) is a syndrome characterised by chronic rhinosinusitis, nasal polyps, asthma and aspirin intolerance. An imbalance of eicosanoid metabolism with anover-production of cysteinyl leukotrienes (CysLTs) has been associated with AERD. However, the precise mechanisms underlying AERD are unknown. Objective: To establish the transcriptome of the nasal polyp airway epithelial cells derived from AERD patients to discover gene expression patterns in this disease. Methods: Nasal airway epithelial cells were isolated from 12 AERD polyps and 8 AERD non-polyp nasal mucosa samples as controls from the same subjects. Utilising the Illumina HiSeq 2500 …
Paternal uniparental disomy chromosome 14-like syndrome due a maternal de novo 160 kb deletion at the 14q32.2 region not encompassing the IG- and the…
2015
The human chromosome 14q32 carries a cluster of imprinted genes which include the paternally expressed genes (PEGs) DLK1 and RTL1, as well as the maternally expressed genes (MEGs) MEG3, RTL1as, and MEG8. PEGs and MEGs expression at the 14q32.2-imprinted region are regulated by two differentially methylated regions (DMRs): the IG-DMR and the MEG3-DMR, which are respectively methylated on the paternal and unmethylated on the maternal chromosome 14 in most cells. Genetic and epigenetic abnormalities affecting these imprinted gene clusters result in two different phenotypes currently known as maternal upd(14) syndrome and paternal upd(14) syndrome. However, only few patients carrying a maternal…
Accessing finite momentum excitations of the one-dimensional Bose-Hubbard model using superlattice modulation spectroscopy
2018
We investigate the response to superlattice modulation of a bosonic quantum gas confined to arrays of tubes emulating the one-dimensional Bose-Hubbard model. We demonstrate, using both time-dependent density matrix renormalization group and linear response theory, that such a superlattice modulation gives access to the excitation spectrum of the Bose-Hubbard model at finite momenta. Deep in the Mott-insulator, the response is characterized by a narrow energy absorption peak at a frequency approximately corresponding to the onsite interaction strength between bosons. This spectroscopic technique thus allows for an accurate measurement of the effective value of the interaction strength. On th…
Are the new genetic tools for diagnosis of Wilson disease helpful in clinical practice?
2020
Summary The diagnosis of Wilson disease is not always easy. For many patients, a combination of tests reflecting disturbed copper metabolism may be needed. Testing for ATP7B variants has become part of the routine diagnostic approach. The methods of genetic testing include analysis of the 21 coding exons and intronic flanking sequences, in which exons with recurrent variants would be prioritised depending on the mutation frequency in the local population. If sequencing the entire ATP7B gene cannot identify 2 variants and the suspicion for Wilson disease is high, after reviewing the clinical data, WES (whole-exome sequencing) or WGS (whole-genome sequencing) could be applied. A workflow base…
Slāpekļa vakances centru relaksācijas laika noteikšana mākslīgā dimanta kristālā
2016
Zināms, ka spinu gareniskās relaksācijas laiks T_1 izteikti korelē ar NV centru koncenrtāciju mērījumu vietā, tomēr nav skaidra precīza atkarība. Tika veikti divi neatkarīgie eksperimenti (Latvijā, LU FMF Lāzeru centrā un ASV, Berklijā), kuru rezultātā iegūtie dati ir pretrunā. Darba mērķis ir noteikt slāpekļa-vakances jeb NV centru T_1 atkarību no to lokālas koncentrācijas mākslīgā dimanta kristālā. Tika izveidota jaunā iekārta lāzeru inducētās fluorescences (LIF) iegūšanai un detektēšanai, kurā pirmo reizi Lāzeru Centra praksē tika izmantots augstās izšķirtspējas eļļas imersijas fluorescences objektīvs. Izmantojot optiski detektētās magnētiskās rezonanses (ODMR) spektrus un programmatūru …
X-Ray Detected Magnetic Resonance: A Unique Probe of the Precession Dynamics of Orbital Magnetization Components
2011
X-ray Detected Magnetic Resonance (XDMR) is a novel spectroscopy in which X-ray Magnetic Circular Dichroism (XMCD) is used to probe the resonant precession of local magnetization components in a strong microwave pump field. We review the conceptual bases of XDMR and recast them in the general framework of the linear and nonlinear theories of ferromagnetic resonance (FMR). Emphasis is laid on the information content of XDMR spectra which offer a unique opportunity to disentangle the precession dynamics of spin and orbital magnetization components at given absorbing sites. For the sake of illustration, we focus on selected examples in which marked differences were found between FMR and XDMR s…
Recombination luminescence of X-ray induced paramagnetic defects in BaY2F8
2020
This research is funded by the Latvian Council of Science , project “Novel transparent nanocomposite oxyfluoride materials for optical applications”, project No. LZP-2018/1–0335 . The crystal growth research was funded by the CNPq (Brazil), project NO 421581/2016–6 .
Slāpekļu vakanču centru T1 relaksācijas laika pētījumi divos ar zemās enerģijas elektroniem apstarotos dimantu paraugos
2017
Slāpekļa vakances centrus dimantos var izmantot, lai noteiktu materiālu iekšējo spriegumu, temperatūru un elektrisko lauku mikroskopiskos telpas apvidos, kā arī, lai novērotu zemu koncentrāciju paramagnetiskās molekulas un jonus, kuru magnētiskais lauks samazina T1 relaksācijas laiku. Slāpekļa vakances dimantos rada ar apstarošanu, parasti ar elektroniem vai citām daļiņām, kuru enerģija ir ap dažiem megaelektronvoltiem. Pētījumā tika izveidoti dimanta paraugi, izmantojot zemas enerģijas elektronus ar transmisijas elektronu mikroskopu, kas ļauj veidot punktveida struktūras dimantā. Pētījumā divos paraugos T1 laika mērījumi atšķirās. Šajā bakalaura darbā autors salīdzināja divus dažādus diman…
Statics and dynamics of weakly coupled antiferromagnetic spin-1/2 ladders in a magnetic field
2011
We investigate weakly coupled spin-1/2 ladders in a magnetic field. The work is motivated by recent experiments on the compound (C5H12N)2CuBr4 (BPCB). We use a combination of numerical and analytical methods, in particular the density matrix renormalization group (DMRG) technique, to explore the phase diagram and the excitation spectra of such a system. We give detailed results on the temperature dependence of the magnetization and the specific heat, and the magnetic field dependence of the nuclear magnetic resonance (NMR) relaxation rate of single ladders. For coupled ladders, treating the weak interladder coupling within a mean-field or quantum Monte Carlo approach, we compute the transit…
Caesarean Section on Maternal Request-Ethical and Juridic Issues: A Narrative Review.
2022
In recent decades, the rate of caesarean deliveries has increased worldwide. The reasons for this trend are still largely misunderstood and controversial among researchers. The decision often depends on the obstetrician, his beliefs and experience, the characteristics of the patients, the hospital environment and its internal protocols, the increasing use of induction of labor, the medico-legal implications, and, finally, the mother’s ability to request delivery by caesarean section without medical indication. This review aims to describe the reasons behind the increasing demand for caesarean sections by patients (CDMR) and strategies aimed at reducing caesarean section rates and educating …