Search results for "DN"
showing 10 items of 13438 documents
Analysis of salivary detection of P16INK4A and RASSF1A promoter gene methylation and its association with oral squamous cell carcinoma in a Colombian…
2019
Background Epigenetic factors play a fundamental role in the etiopathogenesis of oral squamous cell carcinoma (OSCC). This study evaluated if salivary detection of P16INK4A/RASSF1A gene promoter methylation might be linked to the clinical/histological features of OSCC in a Colombian population. Material and Methods Methylation-specific polymerase chain reaction (MSP-PCR) was used to detect the methylation frequency of P16INK4A/RASSF1A genes in DNA obtained from whole saliva collected of 40 healthy controls (HC) and 43 OSCC patients. Determination of the clinical performance of MSP-PCR assay was based on standard algorithms derived from two-way contingency table analysis. The association of …
Cretaceous ultrapotassic magmatism from the Sava-Vardar Zone of the Balkans
2020
Highlights • Geochemically diverse Late Cretaceous small-volume magmatism in the Sava-Vardar Zone. • Late Cretaceous ultrapotassic lava, equivalent of minette and kersantite. • Magma derivation from a LREE and K enriched, garnet-bearing anciently metasomatized mantle source. • Magmatism occurred either in a fore-arc setting or is associated with transtensional tectonics. Abstract Late Cretaceous global plate reorganization associated with the inception of counterclockwise rotation of Africa relative to Europe initiated in the Balkan region small-volume magmatism of diverse geochemical signature along the enigmatic Sava-Vardar Zone. We study a Late Cretaceous lamprophyric sill in Ripanj vill…
Climate change: A driver of future conflicts in the Persian Gulf Region?
2021
Ongoing global change and its direct environmental impacts, in addition to securing economic transition to the post-oil era, could trigger complex socio-economic and political crises in oil-dependent economies of the Persian Gulf Region (PGR). To evaluate the role of climate change and related policies in degrading the environment and its socio-economic impacts in the PGR, we have used a variety of available global datasets and published data. The results show that the countries of the PGR pursue some types of socio-economic reforms to alleviate the impacts of climate change. However, it seems that these attempts are not compatible with the environment's capacity. The main problem stems fro…
Du Néolithique récent à l’âge du Bronze dans le Centre Nord de la France : les étapes de l’évolution chrono-culturelle
2011
Die seit 2001 im Rahmen eines PCR (Programme Collectif Régional) durchgeführte Gemeinschaftsarbeit über das Ende des Neolithikums und den Beginns der Bronzezeit im Zentrum Nordfrankreichs führt heute zu einer neuen Periodisierung der Zeit zwischen 3600 und 1800 v. Chr. in acht Etappen. Obwohl, insbesondere bezüglich der Transition zwischen dem Mittel-und dem Jungneolithikum einerseits und dem Jung-und dem Endneolithikum andererseits, auch weiterhin einige Lücken bestehen, erlaubt dieser präzisere Rahmen die Hauptetappen im Zentrum Nordfrankreichs mit denen der benachbarten Regionen zu synchronisieren, um eine dynamischere Vision der kulturellen Phänomene vorzuschlagen.
Ancient DNA from European early neolithic farmers reveals their near eastern affinities.
2010
The first farmers from Central Europe reveal a genetic affinity to modern-day populations from the Near East and Anatolia, which suggests a significant demographic input from this area during the early Neolithic.
A mitogenome sequence of an Equus hydruntinus specimen from Late Quaternary site of San Teodoro Cave (Sicily, Italy)
2020
Abstract Equus hydruntinus was a small equid that ranged from the Iberian Peninsula to Middle East. In Italy it has been considered present from the Middle Pleistocene to its extinction in the Middle-Late Holocene. E. hydruntinus shares plesiomorphic traits with other known Pleistocene equids. As a consequence, its classification has always been problematic. Genetic analyses on few fossil remains from Iran and Crimea have revealed that E. hydruntinus was more closely related to extant hemiones. To further investigate its systematic position, using target-enrichment capture and next-generation sequencing, we reconstructed a near complete mitogenome of a specimen from San Teodoro Cave from Si…
A 2500 year record of natural and anthropogenic soil erosion in South Greenland
2012
International audience; The environmental impact of the Norse landnám in Greenland has been studied extensively. But to date, no study has quantified the soil erosion that Norse agricultural practices are believed to have caused. To resolve this problem, a high resolution sedimentary record from Lake Igaliku in South Greenland is used to quantitatively reconstruct 2500 years of soil erosion driven by climate and historical land use. An accurate chronology allows for the estimation of detritic fluxes and their uncertainties. Land clearance and the introduction of grazing livestock by the Norse around 1010 AD caused an acceleration of soil erosion up to 8 mm/century in 1180 AD which is two-fo…
Analysis of the bacterial communities in ancient human bones and burial soil samples: Tracing the impact of environmental bacteria
2019
Abstract In our attempts to reveal the hidden fragments of the history of the natural world, ancient DNA (aDNA) is the precious missing key that allows us to discover hidden truths about ourselves and the world around us. Not only does aDNA encrypt genetic data from a particular individual, it also carries information about the microbial communities that were present in the individual. However, the process of such data mining has many intrinsic challenges. One of the main challenges in aDNA research is the contamination of archaeological material with environmental bacteria from the surrounding soil and postmortem microbial sources. The goal of this study was to identify the microbial commu…
Minimally invasive bone biopsies of fully wrapped mummies guided by computed tomography and fibre-optic endoscopy: Methods and suggested guidelines
2020
Abstract Recent advances in the recovery and analysis of ancient DNA (aDNA) and application of isotopic analysis of tissue obtained from mummified human remains has been accompanied by continued advances in non-invasive imaging using X-ray computed tomography (CT) and use of minimally invasive surgical techniques employing small fibre-optic endoscopes. We used these state-of-the-art techniques to examine ancient Egyptian mummies in the Egyptian Museum and Papyrus Collection of Berlin, obtaining bone samples for aDNA, stable isotope analyses and radiocarbon dating. CT and endoscopic guidance were applied to locate and biopsy bones using pre-existing access points in order to avoid any furthe…
Paleogenetic and morphometric analysis of a Mesolithic individual from Grotta d'Oriente: An oldest genetic legacy for the first modern humans in Sici…
2020
Abstract Grotta d’Oriente, a coastal cave located on the island of Favignana (Sicily, Italy) is a key site for the study of the early human colonization of Sicily. Inside the cave, during different field excavations, three burials attributable to the Late Upper Palaeolithic and Mesolithic were found. The Mesolithic Oriente B individual, directly dated at 9,377 ± 25 uncal BP, was previously assigned to HV1 haplogroup using a traditional approach. However, it is well known that PCR based methods are prone to erroneous haplotype or haplogroup determination. In order to redefine the mitochondrial lineage of this Mesolithic hunter-gatherer and explore its phylogenetic position, we target-enriche…