Search results for "DOC"
showing 10 items of 14105 documents
Documents. ‘Parvus’, enigmàtic i fascinant
2022
En el número 69 de la revista L'Espill trobaràs un dossier monogràfic sobre "Monarquia o República", amb contribucions de Gemma Ubasart, Andrés Boix, Joan Manuel Tresserras i Gerardo Pisarello. A més, articles de Josep V. Boira, Lourdes Toledo, Mercè Rius, Antonio Cubel, Maria J. Murgui, José R. Ruiz Tamarit i Antoni Martí Monterde, així com documents d'Alexandr Helphand, un full de dietari de Pere Antoni Pons i una conversa amb Joseph Jurt, per Antoni Martí Monterde.
Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors
2012
Herein we report the synthesis of a set of constrained peptidomimetics endowed with an electrophilic vinyl ester warhead and structurally related to a previously identified lead compound, a potent and irreversible inhibitor of falcipain-2 (FP-2). FP-2 is the main hemoglobinase of the malaria parasite P. falciparum. The new compounds were evaluated for their inhibition against FP-2, and the results were rationalized on the basis of docking experiments. These studies underscore the pivotal role of both the ester function at the P1' site and the trifluoromethyl group of the P3 side chain in determining the correct orientation of the Michael acceptor warhead in the catalytic site, and as a cons…
Teaching competences in Secondary Education : analysis of teachers’ profiles
2014
This paper reports some of the findings from a study that aimed to analyse the importance attributed by secondary education teachers from the province of Castellón (Spain) to teaching competencies and to establish professional profiles from their responses. The survey was based on a purposely designed questionnaire answered by a representative sample of 136 secondary teachers from Castellón, representing 23 school departments. From an analysis of the responses we identified three professional profiles based on the importance that teachers attribute to a range of competencies; although all the competencies were valued highly, we found that teachers still consider the traditional delivery of …
Perfiles docentes en diversos contextos: personalidad, autoconcepto y compromiso educativo
2014
Las personas nos desarrollamos en medio de contextos complejos y multidimensionales, lo que somos es producto de nuestras propias características personales y de las influencias del entorno en el que interactuamos. Es desde el Perú, como país diverso y con culturas milenarias, que planteamos esta investigación que puede ser ubicada en el marco de las ciencias sociales y de la educación. La complejidad de los procesos personales y socioeducativos peruanos nos hizo tomar la ruta de la psicología del desarrollo humano y de la educación para analizar el desarrollo personal de los docentes en diversos contextos. La relevancia del maestro, su protagonismo en el diseño de un itinerario educativo q…
The Educational Implications of the Atomistic Family Structure : How the Atomization of the Family Undermines the Education of Critical Citizens by M…
2017
This article uses historical and sociological research as the basis for a philosophically argued thesis about the negative educational consequences of the atomization of the family structure. Carle Zimmerman’s theory of the social causality involved in the atomistic family structure is illustrated with an example of a Bolshevik social experiment and applied to the atomization of the modern Western family as shown by contemporary social science research. The focus is on the ways that the atomization of the family undermines the education of children into autonomous and critical citizens. Once the normative structures of marriage and family disintegrate, the identity and relationship rights o…
Permutations of zero-sumsets in a finite vector space
2020
Abstract In this paper, we consider a finite-dimensional vector space 𝒫 {{\mathcal{P}}} over the Galois field GF ( p ) {\operatorname{GF}(p)} , with p being an odd prime, and the family ℬ k x {{\mathcal{B}}_{k}^{x}} of all k-sets of elements of 𝒫 {\mathcal{P}} summing up to a given element x. The main result of the paper is the characterization, for x = 0 {x=0} , of the permutations of 𝒫 {\mathcal{P}} inducing permutations of ℬ k 0 {{\mathcal{B}}_{k}^{0}} as the invertible linear mappings of the vector space 𝒫 {\mathcal{P}} if p does not divide k, and as the invertible affinities of the affine space 𝒫 {\mathcal{P}} if p divides k. The same question is answered also in the case where …
Peroxisome Proliferator-Activated Receptors and Atherosclerosis
2011
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, …
Analyse critique des résultats d’une étude de toxicité sur le développement du système nerveux ainsi que d’autres données publiées récemment sur les …
2010
Rapport d’expertise collective AFSSA; Analyse critique des résultats d’une étude de toxicité sur le développement du système nerveux ainsi que d’autres données publiées récemment sur les effets toxiques du bisphénol A
Exposition continue à des mélanges de perturbateurs endocriniens
2012
Dans ce projet, il est question d’explorer les effets de mélanges de perturbateurs endocriniens sur plusieurs générations, en considérant des cibles différentes (appareil reproducteur, glande mammaire, os, dent, tissu adipeux, glandes salivaires, cerveau...) et adaptées à chaque âge pour essayer de mieux comprendre comment agissent des perturbateurs endocriniens, en particulier ceux qui interfèrent avec les hormones sexuelles. Parmi les questions majeures que se pose le scientifique, figurent celles de l’effet d’une exposition prolongée à des mélanges de perturbateurs endocriniens depuis la conception jusqu’à l’âge adulte, et de la possibilité que ces expositions aient des répercussions sur…
Ohjauksen kirjaaminen : tyypin 2 diabetespotilaiden omahoito ja osaaminen potilasasiakirjoissa
2017
The purpose of this study was to describe the contents of type 2 diabetes patient self-management counselling documentation, how counselling of self- management appeared in various content areas and how patients’ self- management competence developed during the counselling. The research data consisted of nurses’ documentations from type 2 diabetes patient self- management counselling situations (N = 60) in primary health care. The data was collected in 2014 from the period between the years 2005 and 2014. Data were analyzed using content analysis as well as a case study approach. The documentation of self-management counselling included entries from content areas on nutrition, exercise, wei…