Search results for "DOC"
showing 10 items of 14105 documents
Physiological and autonomic stress responses after prolonged sleep restriction and subsequent recovery sleep in healthy young men
2018
Purpose Sleep restriction is increasingly common and associated with the development of health problems. We investigated how the neuroendocrine stress systems respond to prolonged sleep restriction and subsequent recovery sleep in healthy young men. Methods After two baseline (BL) nights of 8 h time in bed (TIB), TIB was restricted to 4 h per night for five nights (sleep restriction, SR, n = 15), followed by three recovery nights (REC) of 8 h TIB, representing a busy workweek and a recovery weekend. The control group (n = 8) had 8 h TIB throughout the experiment. A variety of autonomic cardiovascular parameters, together with salivary neuropeptide Y (NPY) and cortisol levels, were assessed.…
Ekumenizm w Polsce w kontekście dokumentów II Polskiego Synodu Plenarnego (1991–1999)
2016
II Polski Synod Plenarny został uroczyście zainaugurowany przez papieża Jana Pawła II w czasie jego wizyty w Polsce w czerwcu 1991 r. Również Jan Paweł II dokonał jego zamknięcia 11 czerwca 1999 r. Prace przygotowawcze do synodu trwały prawie trzy lata. W tym czasie sformułowano istotne problemy, które miały zostać przedyskutowane i przepracowane przez grupy synodalne. W ramach siedemnastu komisji tematycznych zredagowano dokumenty robocze. Ważne miejsce wśród nich zajmuje dokument pt.: Kościół katolicki w Polsce na drodze ekumenizmu. Niestety, dokument ten nie znalazł się wśród czternastu finalnych dokumentów synodu. Owszem, w dokumentach końcowych synodu można znaleźć pewne ekumeniczne od…
Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety
2019
σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain, neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O-heterocycles and amino moieties (general structure III) was prepared and pharmacologically evaluated. In structure-activity relationships studies, the σ1 receptor affinity and σ1:σ2 selectivity were correlated with the stereochemistry, the kind and substitution pattern of the O-heterocycle, and the substituents at the exocyclic amino moiety. cis-configured 2-benzopyran cis-11b bearing a methoxy group and a tertiary cyclohexylmethylamino moiety showed the highest σ1 affinity ( Ki = 1.9 nM) of this series of compounds. In…
Ubezpieczenia społeczne doktorantów szkół doktorskich
2020
Th e reform of the doctoral student education system, resulting in a departure from conducting third degree studies in favour of doctoral schools, resulted in changes in the fi eld of social security law. Th e status of a doctoral student receiving a doctoral scholarship has become independent grounds for compulsory retirement, disability and accident insurance. At the same time, it is the basis for voluntary sickness insurance. Th e author criticises the granting of doctoral students the right to acquire cover under this type of insurance. Th eir actual situation when receiving a doctoral scholarship is far diff erent from the situation of other persons (grounds) covered by sickness insura…
Implementing structured document production to support enterprise content management
2017
Within enterprise content management (ECM), the major goal is to develop and deploy systematic solutions for managing documents and other content items. ECM implementation concerns the development and deployment of new content management solutions and practices in an organization. Extensible Markup Language (XML) offers a standardized format for documents supporting the management and preservation of documents as structured documents. However, the deployment of XML may require a demanding standardization process, changes in work practices, and new tools for document management. Consequently, this research explores the implementation of structured document production environments. The focus …
Design principles for collaboration platforms for open education
2015
Increasing the current low uptake of Open Education Resources (OER) is a key challenge for researchers and practitioners in the field. User studies have shown that collaboration is a main success factor for successful open educational activities. However, effective collaboration in open educational contexts requires well planned processes and platforms supporting collaboration, in particular in physically distributed settings. We have been investigating the value of such platforms, their main features and user requirements to enable collaboration from immature ideas to completed resources. We used quantitative and qualitative research methods to collect insights from potential users of such…
On the motivations to enroll in doctoral studies in Computer Science — A comparison of PhD program models
2013
While student motivation has been intensively researched, only a few studies cover motivation at doctoral level and even less focus on doctoral education in Computer Science. In this paper we investigate the motivation of graduate students to pursue doctoral studies specifically in Computer Science. We interviewed 63 doctoral students, from two different doctoral models (traditional and structured) in Finland and Austria, on their initial reasons and experiences that led them to enroll in doctoral studies. We identified five disjoint main motivational drivers that relate with different aspects of extrinsic and intrinsic motivation. Together with a measure of the strength of their initial mo…
Flexible entity search on surfaces
2016
Surface computing allows flexible search interaction where users can manipulate the representation of entities recommended for them to create new queries or augment existing queries by taking advantage of increased screen estate and almost physical tactile interaction. We demonstrate a search system based on 1) Direct Manipulation of Entity Representation on Surfaces and 2) Entity Recommendation and Document Retrieval. Entities are modeled as a knowledge-graph and the relevances of entities are computed using the graph structure. Users can manipulate the representation of entities via spatial grouping and assigning preferences on entities. Our contribution can help to design effective infor…
Evidence of Weak Halogen Bonding: New Insights on Itraconazole and its Succinic Acid Cocrystal
2012
Exact knowledge of the crystal structure of drugs and lead compounds plays a significant role in the fields of crystal engineering, docking, computational modeling (drug–receptor interactions), and rational design of potent drugs in pharmaceutical chemistry. The succinic acid cocrystal of the systemic antifungal drug, itraconazole, reported by Remenar et al. (J. Am. Chem. Soc.2003, 125, 8456–8457) (CSD: IKEQEU), represents one of the classical examples displaying a molecular fitting mechanism in the solid state. In this work, we disclose the X-ray single-crystal structure of the cis-itraconazole–succinic acid (2:1) cocrystal and found that it differs slightly from the previously reported st…
Exercising exclusions: Space, visibility, and monitoring of the exercising fat female body
2019
The author’s aim is to inspect the position of the fat (female) body in the field of exercise. Specifically, the author is interested in fat women’s experiences of their treatment while exercising in public, and argues that, in particular, public spaces for exercise, such as gyms and swimming pools, are currently discursively and concretely constructed as “exclusive” spaces for the normative bodied. Bodies that are deemed non-normative, such as fat bodies, are often made either invisible or intolerable in the discourse of physical activity and exercise. Consequently, public spaces for exercise such as gyms or swimming pools are seen as out of bounds for non-normative bodies and this is refl…