Search results for "DOM"
showing 10 items of 12668 documents
The N-terminal domain of the light-harvesting chlorophyll a/b-binding protein complex (LHCII) is essential for its acclimative proteolysis.
2000
AbstractVariations in the amount of the light-harvesting chlorophyll a/b-binding protein complex (LHCII) is essential for regulation of the uptake of light into photosystem II. An endogenous proteolytic system was found to be involved in the degradation of LHCII in response to elevated light intensities and the proteolysis was shown to be under tight regulation [Yang, D.-H. et al. (1998) Plant Physiol. 118, 827–834]. In this study, the substrate specificity and recognition site towards the protease were examined using reconstituted wild-type and mutant recombinant LHCII. The results show that the LHCII apoprotein and the monomeric form of the holoprotein are targeted for proteolysis while t…
Liquid−Liquid Equilibria for the System 1-Methyl Propyl Ethanoate (1) + Acetic Acid (2) + Water (3) at (283.15 and 323.15) K
2009
Liquid−liquid equilibrium (LLE) data for the system 1-methyl propyl ethanoate + acetic acid + water were measured at temperatures of (283.15 and 323.15) K. The temperature influence on the LLE data is very small in the temperature range studied. The NRTL and UNIQUAC models were used to correlate the data for both ternary systems. The interaction parameters obtained from both models successfully correlated the equilibrium compositions.
A Difficult Case of Necrotizing Fasciitis Caused By Acinetobacter baumannii
2010
This study reports the case of a 55-year-old woman with diabetes with a necrotizing fasciitis of the right lower limb and the perineum, first admitted at the emergency department for septic shock with cardiac arrest, and later transferred to the department of surgery. Microbiological and histopathological examination confirmed the diagnosis of necrotizing fasciitis caused by Acinetobacter baumanii. A broad-spectrum antibiotic therapy was administered and later readjusted according to the results of microbiological culture. Intensive hemodynamic support was required. Wounds were dressed daily with a 3 percent boric acid solution and a silver sulfadiazine-impregnated dressing. An extensive s…
Biofilmas un metallo-β-laktamāzes producēšanas noteikšana Pseudomonas aeruginosa un Acinetobacter baumannii baktēriju almos
2020
Pseudomonas aeruginosa un Acinetobacter baumannii metallo-β-laktamāžu producēšana ir kļuvusi par pieaugošu terapeitisko problēmu visā pasaulē, kā arī antibiotiku rezistentiem celmiem ir spēja veidot noturīgākas biofilmas, kas rada problēmas šo patogēnu izraisīto infekciju ārstēšanā. Darba mērķis: noteikt Pseudomonas aeruginosa un Acinetobacter baumannii spēju veidot biofilmas, producēt metallo- β-laktamāzes, kā arī statistiski apkopot datus par jutību pret antibakteriālajiem līdzekļiem starp 2017. gadu un 2019. gadu, un veikt rezistences izmaiņas salīdzinājumu. Uzdevumi: identificēt no elpceļiem iegūtos izolātus ar BBL™ Crystal™ sistēmu, kā arī ar GenoType® BC gramnegative testu, veikt anti…
Drug resistance patterns of bacteria isolated from patients with nosocomial pneumonia at Tehran hospitals during 2009-2011
2013
Introduction: Nosocomial pneumonia remains an important cause of mortality and morbidity worldwide. Surveillance programs play an important role in the identification of common etiologic agents and local patterns of antimicrobial resistance. Methodology: In this study we determined the frequency and antimicrobial susceptibility of pathogens isolated from patients with nosocomial pneumonia during 2009 to 2011. Results: A total of 642 bacteria were isolated from 516 suspected samples. Acinetobacter baumannii (21.1%, n = 136), was the commonest isolated pathogen followed by Pseudomonas aeruginosa (17.4%, n = 112) , Staphylococcus aureus (15.8%, n = 102) and enterococci (8.4% n = 54). The most …
Cladosins L-O, new hybrid polyketides from the endophytic fungus Cladosporium sphaerospermum WBS017
2019
Abstract The endophytic fungus Cladosporium sphaerospermum WBS017 was obtained from healthy bulbs of Fritillaria unibracteata var. wabuensis. Fermentation of C. sphaerospermum on solid rice medium yielded three new hybrid polyketides, cladosins L−N (1–3), and a known derivative cladodionen (4). Further cultivation of this fungus on white bean medium afforded an additional new hybrid polyketide, cladosin O (5) along with three known analogues (6–8). The structures of the new compounds were elucidated using a combination of NMR and HRESIMS data. The absolute configurations of compounds 2 and 3 were determined by Mosher’s method and TDDFT-ECD calculations. All isolated compounds were evaluated…
High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors
2016
International audience; Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses the first, irreversible step in lipid A biosynthesis) are a promising new class of antibiotics against Gram-negative bacteria. The objectives of the present study were to: (i) compare the antibiotic activities of three LpxC inhibitors (LPC-058, LPC-011 and LPC-087) and the reference inhibitor CHIR-090 against Gram-negative bacilli (including MDR and XDR isolates); and (ii) investigate the effect of combining these inhibitors with conventional antibiotics.MethodsMICs were determined for 369 clinical isolates (234 Enterobacteriaceae and 135 non-fermentati…
Pseudomonas aeruginosa un Acinetobacter baumanii jutība pret antibakteriālajiem līdzekļiem
2018
Pseudomonas aeruginosa un Acinetobacter baumannii ir galvenie ar veselības aprūpes saistīto infekciju (VASI) izraisītāji. Šo patogēnu rezistence pret antibakteriālajiem līdzekļiem pēdējo gadu laikā ir strauji palielinājusies, un ir viena no aktuālākajām problēmām mūsdienās. Darba mērķis: izpētīt gramnegatīvo baktēriju P. aeruginosa un A. baumannii jutību pret antibakteriālajiem līdzekļiem, salīdzināt antibakteriālās rezistences izmaiņas divu gadu laikā. Uzdevumi: identificēt no elpceļiem iegūtos izolātus ar BBL™ Crystal™ sistēmu, veikt antibakteriālo līdzekļu jutības testus, izmantojot Bauer – Kirby disku difūzijas testu un E – testu, fenotipēšanu veikt pēc antibiogrammām. Rezultātus apko…
Acinetobacter baumannii un Pseudomonas aeruginosa antibakteriālās rezistences noteikšana, lietojot fenotipiskās un molekulāri bioloģiskās metodes
2020
Acinetobacter baumannii un Pseudomonas aeruginosa ir gan Latvijā, gan visā Eiropā bieži sastopami intrahospitāli patogēni, pret kuriem antibiotiku rezistence pieaug ik gadu. Visbiežāk tie skar imūnsupresētus cilvēkus, apdraudot veselību un dzīvību. Darba mērķis: Noteikt A.baumannii un P. aeruginosa jutību pret antibakteriālajiem līdzekļiem 2019. gadā un salīdzināt rezistences izmaiņas ar 2017. gadu, kā arī ar molekulāri bioloģisko metodi identificēt baktēriju sugas. Uzdevumi: 1.No elpceļu paraugiem ar BBL CrystalTM identifikācijas sistēmām identificēt izolātus. 2. Noteikt antimikrobiālo jutību, izmantojot Bauer-KirbyTM disku difūzijas testu un MIC, lietojot ETM-testu. 3. Tipēt izdalīto bakt…
A spatially resolved investigation of the local, micro-magnetic domain structure of single and polycrystalline Co2FeSi
2007
The Heusler compound Co2FeSi is a promising material for magneto-electronic devices. With a Curie temperature of 1100?K and a saturation magnetization of 6?Bohr magnetons and a high spin polarization at the Fermi edge it fulfils the essential requirements for magnetic sensors or spin valve structures. An essential feature for such devices is the micro-magnetic domain structure. X-ray magnetic circular dichroism?photo emission electron microscopy has been used for a direct observation of the domain structure of single- and polycrystalline samples. The polycrystalline material exhibits a micro-magnetic ripple structure, as it is well known for pure Co and other polycrystalline Heusler compoun…