Search results for "DOMAIN"
showing 10 items of 2485 documents
Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells
2013
AbstractPluripotency is maintained by both known and unknown transcriptional regulatory networks. In the present study, we have identified Zfp819, a KRAB-zinc finger protein, as a novel pluripotency-related factor and characterized its role in pluripotent stem cells. We show that Zfp819 is expressed highly in various types of pluripotent stem cells but not in their differentiated counterparts. We identified the presence of non-canonical nuclear localization signals in particular zinc finger motifs and identified them as responsible for the nuclear localization of Zfp819. Analysis of the Zfp819 promoter region revealed the presence of a transcriptionally active chromatin signature. Moreover,…
Girl With Partial Turner Syndrome and Absence Epilepsy
2007
This report describes a 16-year-old girl with short stature (-5 standard deviations), normal puberty, panic attacks, absence epilepsy, some stigmata of Turner syndrome, and a Madelung deformity. Routine chromosomal analysis revealed a female karyotype with one abnormal chromosome X, with the suspicion of additional material on the short arm. With fluorescent in situ hybridization and array-multiplex amplifiable probe hybridization methodology, a complex aberration was detected, with a deletion of the distal part of Xp22.33 (including the short-stature homeobox gene) and a duplication of Xp22.32-p22.12 proximal to the deleted segment. The deletion in our patient involves the Xp22.33 region. …
Actin binding LIM protein 3 (abLIM3).
2005
LIM domain proteins were demonstrated to play key roles in various biological processes such as embryonic development, cell lineage determination, and cancer differentiation. Actin binding LIM protein 1 (abLIM1) was reported to be localized in a genomic region often deleted in human cancers and suggested to be involved in axon guidance. Recently, existence of a second family member was reported, actin binding LIM protein 2. By means of computational biology and comparative genomics, we now characterized an additional, third member of the actin binding LIM protein subgroup, actin binding LIM protein 3 (abLIM3). The human mRNA sequence was previously annotated as differentially regulated in h…
Lack of association of HOXA1 and HOXB1 mutations and autism in Sicilian (Italian) patients
2003
Lack of association of HOXA1 and HOXB1 mutations and autism in Sicilian (Italian) patients
One- and two-photon lasers with injected signal in a high-Q fabry-Pérot cavity
2000
Explicit models are derived for good cavity one- and two-photon lasers with an injected signal in a Fabry-Perot cavity. The steady solutions and their stability properties are obtained analytically and compared with the corresponding ring cavity model ones. Only quantitative differences between both types of cavities are found. In particular we show that (i) the Fabry-Perot cavity reduces significantly the domain of self-pulsing with respect to the ring cavity, and for the two-photon laser case (ii) larger output can be extracted from a Fabry-Perot cavity than from a ring cavity under certain conditions, something impossible in free-running lasers. We conclude that ring cavity models are se…
Database to Ontology Mapping Patterns in RDB2OWL Lite
2016
We describe the RDB2OWL Lite language for relational database to RDF/OWL mapping specification and discuss the architectural and content specification patterns arising in mapping definition. RDB2OWL Lite is a simplification of original RDB2OWL with aggregation possibilities and order-based filters removed, while providing in-mapping SQL view definition possibilities. The mapping constructs and their usage patterns are illustrated on mapping examples from medical domain: medicine registries and hospital information system. The RDB2OWL Lite mapping implementation is offered both via translation into D2RQ and into standard R2RML mapping notations.
Intention recognition in manufacturing applications
2015
In this article, we present a novel approach to intention recognition, based on the recognition and representation of state information in a cooperative human-robot environment. States are represented by a combination of spatial relations along with cardinal direction information. The output of the Intention Recognition Algorithms will allow a robot to help a human perform a perceived operation or, minimally, not cause an unsafe situation to occur. We compare the results of the Intention Recognition Algorithms to those of an experiment involving human subjects attempting to recognize the same intentions in a manufacturing kitting domain. In almost every case, results show that the Intention…
User-Centered Design for Biomedical Literature Search User Interfaces
2019
Biomedical literature search tools are crucial resources for the work of physicians, biologists, and bioinformatics. Many of the genetic-medical diagnoses depend on the findings in these literature resources. Despite the importance and value of the information stored in these resources, the user interface (UI) implemented by such tools present several usability problems converting the query and interpretation of the information into complex and time-consuming tasks. In this sense, an user-centered design (UCD) approach can improve the usability of these UIs facilitating the interaction, analysis, and comparison of biomedical information, and, consequently, improving the productivity of prac…
Lead-Lag-Shaped Interactive Force Estimation by Equivalent Output Injection of Sliding-Mode
2020
Estimation of interactive forces, which are mostly unavailable for direct measurement on the interface between a system and its environment, is an essential task in various motion control applications. This paper proposes an interactive force estimation method, based on the well-known equivalent output injection of the second-order sliding mode. The equivalent output injection is used to obtain a frequency-unshaped quantity that appears as a matched external disturbance and encompasses the interactive forces. Afterwards, a universal lead-lag shaper, depending on dynamics of the motion control system coupled with its environment, is used to extract an interactive force quantity. Once identif…
N- and O-methylation of sphingomyelin markedly affects its membrane properties and interactions with cholesterol
2011
We have prepared palmitoyl sphingomyelin (PSM) analogs in which either the 2-NH was methylated to NMe, the 3-OH was methylated to OMe, or both were methylated simultaneously. The aim of the study was to determine how such modifications in the membrane interfacial region of the molecules affected interlipid interactions in bilayer membranes. Measuring DPH anisotropy in vesicle membranes prepared from the SM analogs, we observed that methylation decreased gel-phase stability and increased fluid phase disorder, when compared to PSM. Methylation of the 2-NH had the largest effect on gel-phase instability (T(m), was lowered by similar to 7 degrees C). Atomistic molecular dynamics simulations sho…