Search results for "DOMAIN"
showing 10 items of 2485 documents
Transient structural ordering of the RNA-binding domain of carnation mottle virus p7 movement protein modulates nucleic acid binding.
2005
Plant viral movement proteins bind to RNA and participate in the intra- and intercellular movement of the RNAs from plant viruses. However, the role and magnitude of the conformational changes associated with the formation of RNA-protein complexes are not yet defined. Here we describe studies on the relevance of a preexisting nascent alpha-helix at the C terminus of the RNA-binding domain of p7, a movement protein from carnation mottle virus, to RNA binding. Synthetic peptide analogues and single amino acid mutation at the RNA-binding domain of recombinant p7 protein were used to correlate the transient structural order in aqueous solution with RNA-binding potential.
A Novel Semi-Supervised Methodology for Extracting Tumor Type-Specific MRS Sources in Human Brain Data
2013
Background: The clinical investigation of human brain tumors often starts with a non-invasive imaging study, providing \ud information about the tumor extent and location, but little insight into the biochemistry of the analyzed tissue. Magnetic \ud Resonance Spectroscopy can complement imaging by supplying a metabolic fingerprint of the tissue. This study analyses \ud single-voxel magnetic resonance spectra, which represent signal information in the frequency domain. Given that a single \ud voxel may contain a heterogeneous mix of tissues, signal source identification is a relevant challenge for the problem of\ud tumor type classification from the spectroscopic signal.\ud Methodology/Princ…
Wide-Field Imaging of Superconductor Vortices with Electron Spins in Diamond
2018
Understanding the mechanisms behind high-$T_{c}$ Type-II superconductors (SC) is still an open task in condensed matter physics. One way to gain further insight into the microscopic mechanisms leading to superconductivity is to study the magnetic properties of the SC in detail, for example by studying the properties of vortices and their dynamics. In this work we describe a new method of wide-field imaging magnetometry using nitrogen-vacancy (NV) centers in diamond to image vortices in an yttrium barium copper oxide (YBCO) thin film. We demonstrate quantitative determination of the magnetic field strength of the vortex stray field, the observation of vortex patterns for different cooling fi…
Phase separated Cu@Fe3O4 heterodimer nanoparticles from organometallic reactants
2011
Cu@Fe3O4 heteroparticles with distinct morphologies were synthesized from organometallic reactants. The shape of the magnetic domains could be controlled by the solvent and reaction conditions. They display magnetic and optical properties that are useful for simultaneous magnetic and optical detection. After functionalization, the Cu@Fe3O4 heterodimers become water soluble. The morphology, structure, magnetic and optical properties of the as-synthesized heterodimer nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), mossbauer spectroscopy, superconducting quantum interference device (SQUID) magnetometry, and dark field imaging. A special a…
New ultraportable data logger to perform magnetic surveys
2019
This article presents the realization of a device for magnetic surveys It is a flexible, user-reprogramable, lightweight, and compact tool that can be easily integrated with aerial and marine drones. The device can accurately measure the local magnetic anomalies. It is based on the Atmega 2560 microcontroller and a digital 3-axis fluxgate magnetometer.
Magnetic states in low-pinning high-anisotropy material nanostructures suitable for dynamic imaging
2013
We present magnetic domain states in a material configuration with high (perpendicular) magnetic anisotropy and particularly low magnetic pinning. This material, a B-doped Co/Pt multilayer configuration, exhibits a strong magnetic contrast in x-ray transmission experiments, making it apt for dynamic imaging with modern synchrotron techniques, providing high spatial and high temporal resolution simultaneously. By analyzing the static spin structures in nanodisks at variable external fields, we show that CoB/Pt multilayers exhibit low enough domain wall pinning to manipulate the domain pattern with weak stimuli and in particular to move domains and domain walls. We demonstrate in a proof-of-p…
Spin orbit torque switching in Ta/CoFeB/MgO without longitudinal fields
2015
Intense investigations are carried out on novel magnetic materials systems with perpendicular magnetic anisotropy (PMA), where new spin-orbit effects occur due to structural inversion asymmetry (SIA). So called spin-orbit torques (SOTs), have been observed for the first time in PMA nano-structures with SIA, when an electric current is injected [1-3], leading to ultra-efficient current-induced domain wall motion and current-induced magnetization switching [2,3].
Theory of domain-wall magnetoresistance in metallic antiferromagnets
2020
We develop a theory to compute the domain-wall magnetoresistance (DWMR) in antiferromagnetic (AFM) metals with different spin structures. In the diffusive transport regime, the DWMR can be either {\it negative} or positive depending on the domain-wall orientation and spin structure. In contrast, when the transport is in the ballistic regime, the DWMR is always positive, and the magnitude depends on the width and orientation of the domain wall. Our results pave the way of using electrical measurements for probing the internal spin structure in antiferromagnetic metals.
The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models
2018
IL6/STAT3 signaling is associated with endocrine therapy resistance in prostate cancer, but therapies targeting this pathway in prostate cancer were unsuccessful in clinical trials so far. The mechanistic explanation for this phenomenon is currently unclear; however, IL6 has pleiotropic effects on a number of signaling pathways, including the androgen receptor (AR). Therefore, we investigated IL6-mediated AR activation in prostate cancer cell lines and ex vivo primary prostate tissue cultures in order to gain a better understanding on how to inhibit this process for future clinical trials. IL6 significantly increased androgen-dependent AR activity in LNCaP cells but importantly did not infl…
Melatonin protects rats from radiotherapy-induced small intestine toxicity
2017
Radiotherapy-induced gut toxicity is among the most prevalent dose-limiting toxicities following radiotherapy. Prevention of radiation enteropathy requires protection of the small intestine. However, despite the prevalence and burden of this pathology, there are currently no effective treatments for radiotherapy-induced gut toxicity, and this pathology remains unclear. The present study aimed to investigate the changes induced in the rat small intestine after external irradiation of the tongue, and to explore the potential radio-protective effects of melatonin gel. Male Wistar rats were subjected to irradiation of their tongues with an X-Ray YXLON Y.Tu 320-D03 irradiator, receiving a dose o…