Search results for "DOMAIN"
showing 10 items of 2485 documents
A survey on solvable sesquilinear forms
2018
The aim of this paper is to present a unified theory of many Kato type representation theorems in terms of solvable forms on a Hilbert space \((H,\langle\cdot,\cdot\rangle)\) In particular, for some sesquilinear forms Ω on a dense domain \(D\subseteq\mathcal {H}\) one looks for a representation \(\Omega(\xi,\eta)= \langle T\xi,\eta\rangle\) \((\xi\epsilon\mathcal{D}\mathcal(T),\eta\epsilon D)\) where T is a densely defined closed operator with domain \(D(\mathcal{T})\subseteq \mathcal{D}\). There are two characteristic aspects of a solvable form on H. One is that the domain of the form can be turned into a reexive Banach space that need not be a Hilbert space. The second one is that represe…
Fiber-based measurement of temporal intensity and phase profiles of an optical telecommunication pulse through self-phase modulation
2018
International audience; We propose and experimentally validate an all-fiber based approach to characterize the phase and intensity profiles of optical pulses. Based on three optical spectra affected by different levels of self-phase modulation, we were able to reconstruct the temporal details of pulses typical of optical telecommunications.
FDTD analysis of E-sectoral horn antennas for broad-band applications
1997
The finite-difference time-domain (FDTD) method is applied to study the performance of E-plane sectoral horn antennas designed for broad-band applications. These antennas (proposed for 6-18 GHz phased arrays) have a large bandwidth, and they are easily array integrated. These antennas have a highly complicated geometry that is modeled using a polygonal approximation in the curved boundaries. Perfect matched layers (PMLs) combined with first-order absorbing boundaries are employed to simulate the free-space environment in the FDTD mesh.
Fixed domain approaches in shape optimization problems with Dirichlet boundary conditions
2009
Fixed domain methods have well-known advantages in the solution of variable domain problems including inverse interface problems. This paper examines two new control approaches to optimal design problems governed by general elliptic boundary value problems with Dirichlet boundary conditions. Numerical experiments are also included peerReviewed
Helmholtz equation in unbounded domains: some convergence results for a constrained optimization problem
2016
We consider a constrained optimization problem arising from the study of the Helmholtz equation in unbounded domains. The optimization problem provides an approximation of the solution in a bounded computational domain. In this paper we prove some estimates on the rate of convergence to the exact solution.
Conceptual Characterization of Cybersecurity Ontologies
2020
Part 7:Risk and Security Modeling; International audience; Cybersecurity is known as the practice of protecting systems from digital attacks. Organizations are seeking efficient solutions for the management and protection of their assets. It is a complex issue, especially for great enterprises, because it requires an interdisciplinary approach. The kinds of problems enterprises must deal with and this domain complexity induces misinterpretations and misunderstandings about the concepts and relations in question. This article focus on dealing with Cybersecurity from an ontological perspective. The first contribution is a search of previously existing works that have defined Cybersecurity Ont…
Key-ring structure gradients and sheath folds in the Goantagab Domain of NW Namibia
2011
Abstract The concept of deformation phases is one of the corner stones of structural geology but, despite its simplicity, there are situations where the concept breaks down. In the Goantagab Domain of NW Namibia, structures in an area of complex deformation can be subdivided into at least four sets, attributed to four deformation phases on the basis of overprinting relations. Three of these sets of structures, however, formed during the same tectonic event under similar metamorphic circumstances but slightly different flow conditions. These sets of structures show gradational transitions in space that can be understood by a concept of “key-ring structure gradients”, where older D A structur…
Lipid rafts: a signalling platform linking lipoprotein metabolism to atherogenesis.
2012
Lipid rafts are microdomains of the plasma membrane which are enriched in cholesterol and sphingolipids. They serve as a platform for signal transduction, in particular during immune and inflammatory responses. As hypercholesterolemia and inflammation are two key elements of atherogenesis, it is conceivable that the cholesterol and cholesterol oxide content of lipid rafts might influence the inflammatory signalling pathways, thus modulating the development of atherosclerosis. In support of this emerging view, lipid rafts have been shown to be involved in several key steps of atherogenesis, such as the oxysterol-mediated apoptosis of vascular cells, the blunted ability of high density lipopr…
The cytoplasmic PASC domain of the sensor kinase DcuS of Escherichia coli : role in signal transduction, dimer formation, and DctA interaction
2013
The cytoplasmic PAS(C) domain of the fumarate responsive sensor kinase DcuS of Escherichia coli links the transmembrane to the kinase domain. PAS(C) is also required for interaction with the transporter DctA serving as a cosensor of DcuS. Earlier studies suggested that PAS(C) functions as a hinge and transmits the signal to the kinase. Reorganizing the PAS(C) dimer interaction and, independently, removal of DctA, converts DcuS to the constitutive ON state (active without fumarate stimulation). ON mutants were categorized with respect to these two biophysical interactions and the functional state of DcuS: type I-ON mutations grossly reorganize the homodimer, and decrease interaction with Dct…
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…