Search results for "DOMAIN"
showing 10 items of 2485 documents
α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation
2009
The Swedish mutation within the amyloid precursor protein (APP) causes early-onset Alzheimer's disease due to increased cleavage of APP by BACE1. While beta-secretase shedding of Swedish APP (APPswe) largely results from an activity localized in the late secretory pathway, cleavage of wild-type APP occurs mainly in endocytic compartments. However, we show that liberation of Abeta from APPswe is still dependent on functional internalization from the cell surface. Inspite the unchanged overall beta-secretase cleaved soluble APP released from APP(swe) secretion, mutations of the APPswe internalization motif strongly reduced C99 levels and substantially decreased Abeta secretion. We point out t…
Reliability and validity of time domain heart rate variability during daily rout¡ne activities : an alternative to the morning orthostatic test?
2017
Summary Study aim: To determine the reliability and validity of a time domain heart rate variability (HRV) index during free-living physical activity (FLPA). Material and methods: Eight white-collar workers participated in this study. RR intervals (time between consecutive R-peaks of the PQRS complex) were recorded using the Polar V800 heart rate (HR) monitor upon awakening and at work on 16 different days. A total of 127 cycles of sitting periods followed by walking breaks were included for consecutive pairwise analysis for reliability. The HR values from the orthostatic test (OT) were compared with the corresponding values at work. Results: The HR values showed high levels of repeatabilit…
Quadrature domains for the Helmholtz equation with applications to non-scattering phenomena
2022
In this paper, we introduce quadrature domains for the Helmholtz equation. We show existence results for such domains and implement the so-called partial balayage procedure. We also give an application to inverse scattering problems, and show that there are non-scattering domains for the Helmholtz equation at any positive frequency that have inward cusps.
Isolation and characterization of microsatellite markers in the liver fluke (Fasciola hepatica)
2004
PRIMER NOTE; International audience; Six microsatellite markers were isolated from Fasciola hepatica, a re-emerging parasite that causes important veterinary and public health problems. In a sample of 52 liver flukes from a region of hyperendemicity (Bolivian Altiplano), five microsatellite were polymorphic. Our results showed that liver flukes present important genetic variability, suggesting a preferential outcrossing reproduction mode for this hermaphroditic parasite.
Analytical models for the pulse shape of a superconductor-ferromagnet tunnel junction thermoelectric microcalorimeter
2022
AbstractThe superconductor-ferromagnet thermoelectric detector (SFTED) is a novel ultrasensitive radiation detector based on the giant thermoelectric effect in superconductor-ferromagnet tunnel junctions. We demonstrate analytical models and solutions in the time domain for a SFTED operated as a microcalorimeter (pulse excitation), in the linear small-signal limit. Based on these solutions, the signal current and temperature pulse response were studied for two different electrical circuit models, providing design conditions for stable and non-oscillatory response.Kindly check and confirm whether the corresponding author is correctly identified.The corresponding author is correct.
Validation and Extension of the Usability Heuristics for Mobile Map Applications
2016
Heuristic usability evaluation is light but efficient method for finding usability problems. In this paper, we report the process of validation and further development of the previously introduced usability heuristics for mobile map applications. The validation began by testing the heuristics by 58 evaluators who used them for usability evaluation of four different map applications. The evaluators also filled a questionnaire about the understandability of the heuristics. The amount, severity and quality of the problems found with the heuristics were reviewed and the heuristics’ understandability analyzed. As a result, it was shown that the heuristics were efficient for finding usability pro…
Incremental elastoplastic analysis for active macro-zones
2012
In this paper a strategy to perform incremental elastoplastic analysis using the symmetric Galerkin boundary element method for multidomain type problems is shown. The discretization of the body is performed through substructures, distinguishing the bem-elements characterizing the so-called active macro-zones, where the plastic consistency condition may be violated, and the macro-elements having elastic behaviour only. Incremental analysis uses the well-known concept of self-equilibrium stress field here shown in a discrete form through the introduction of the influence matrix (self-stress matrix). The nonlinear analysis does not use updating of the elastic response inside each plastic loop…
Analysis of the psicometric properties of a multiplication and division processes assessment scale
2019
Esta comunicación se encuentra disponible en la siguiente URL: http://www.infad.eu/RevistaINFAD/OJS/index.php/IJODAEP/article/view/1464/1321 Este número está dedicado a la "Psicología de la Educación y Saberes Originarios". The domain of multiplication and division operations depends on both algorithm management and the ability to identify the semantic structure of the problem and to translate it into mathematical language. Many students present difficulties in identifying the semantic structure of the problem but not applying the algorithm when the problem is presented numericaly. The aim of the study is to validate an assessment tool of the processes involved in multiplication and divisio…
Global representation and multiscale expansion for the Dirichlet problem in a domain with a small hole close to the boundary
2019
For each pair (Formula presented.) of positive parameters, we define a perforated domain (Formula presented.) by making a small hole of size (Formula presented.) in an open regular subset (Formula presented.) of (Formula presented.) ((Formula presented.)). The hole is situated at distance (Formula presented.) from the outer boundary (Formula presented.) of the domain. Thus, when (Formula presented.) both the size of the hole and its distance from (Formula presented.) tend to zero, but the size shrinks faster than the distance. Next, we consider a Dirichlet problem for the Laplace equation in the perforated domain (Formula presented.) and we denote its solution by (Formula presented.) Our ai…
Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs).
2013
Abstract Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein-protein interaction. Most of them also contain a C-terminal RING domain conferring an E3-ubiquitin ligase activity. In drosophila, IAPs are essential to ensure cell survival, preventing the uncontrolled activation of the apoptotic protease caspases. In mammals, IAPs can also regulate apoptosis through controlling caspase activity and caspase-activating platform format…