Search results for "DOMAIN"
showing 10 items of 2485 documents
Multimodal and Agent-Based Human–Computer Interaction in Cultural Heritage Applications: an Overview
2010
One of the most recent and interesting applications of human–computer interaction technologies is the provision of advanced information services within public places, such as cultural heritage sites or schools and university campuses. In such contexts, concurrent technologies used in smart mobile devices can be used to satisfy the mobility need of users allowing them to access relevant resources in a context-dependent manner. Of course, most of the constraints to be taken into account when designing a pervasive information providing system are given by the actual domain where they are deployed.
A Robotic Humanoid for Information Exploration on Cultural Heritage Domain
2020
The work presented here illustrates an humanoid robot capable of interacting with an human user within the Cultural Heritage domain. Two different and complementary AI approaches, namely sub-symbolic and symbolic, have been implemented and combined together to design the framework of a robot having both rational and intuitive capabilities. Furthermore, the robot is capable of providing information expressively and of adapting its behavior according to the emotional content of the artworks descriptions. This could make the robot more effective in providing information and entertaining the users.
A WAVELET OPERATOR ON THE INTERVAL IN SOLVING MAXWELL'S EQUATIONS
2011
In this paper, a differential wavelet-based operator defined on an interval is presented and used in evaluating the electromagnetic field described by Maxwell's curl equations, in time domain. The wavelet operator has been generated by using Daubechies wavelets with boundary functions. A spatial differential scheme has been performed and it has been applied in studying electromagnetic phenomena in a lossless medium. The proposed approach has been successfully tested on a bounded axial-symmetric cylindrical domain.
An improved smoothed particle electromagnetics method in 3D time domain simulations
2011
In this paper, an enhanced variant of the meshless smoothed particle electromagnetics (SPEM) method is performed in order to solve PDEs in time domain describing 3D transient electromagnetic phenomena. The method appears to be very efficient in approximating spatial derivatives in the numerical treatment of Maxwell's curl equations. In many cases, very often, accuracy degradation, due to a lack of particle consistency, severely limits the usefulness of this approach. A numerical corrective strategy, which allows to restore the SPEM consistency, without any modification of the smoothing kernel function and its derivatives, is presented. The method allows to restore the same order of consiste…
Modification of Dzyaloshinskii-Moriya-Interaction-Stabilized Domain Wall Chirality by Driving Currents
2018
We measure and analyze the chirality of Dzyaloshinskii-Moriya-interaction (DMI) stabilized spin textures in multilayers of $\mathrm{Ta}|{\mathrm{Co}}_{20}{\mathrm{F}}_{60}{\mathrm{B}}_{20}|\mathrm{MgO}$. The effective DMI is measured experimentally using domain wall motion measurements, both in the presence (using spin-orbit torques) and absence of driving currents (using magnetic fields). We observe that the current-induced domain wall motion yields a change in effective DMI magnitude and opposite domain wall chirality when compared to field-induced domain wall motion (without current). We explore this effect, which we refer to as current-induced DMI, by providing possible explanations for…
Three-dimensional numerical simulations on wind- and tide-induced currents: The case of Augusta Harbour (Italy)
2014
The hydrodynamic circulation in the coastal area of the Augusta Bay (Italy), located in the eastern part of Sicily, is analysed. Due to the heavy contamination generated by the several chemical and petrochemical industries active in the zone, the harbour was declared a Contaminated Site of National Interest. To mitigate the risks connected with the industrial activities located near the harbour, it is important to analyse the hydrodynamic circulation in the coastal area. To perform such analysis, a parallel 3D numerical model is used to solve the Reynolds-averaged momentum and mass balance, employing the k-e turbulence model for the Reynolds stresses. The numerical model is parallelized usi…
The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium
2019
Microcystins are a family of chemically diverse hepatotoxins produced by distantly related cyanobacteria and are potent inhibitors of eukaryotic protein phosphatases 1 and 2A. Here we provide evidence for the biosynthesis of rare variants of microcystin that contain a selection of homo-amino acids by the benthic cyanobacterium Phormidium sp. LP904c. This strain produces at least 16 microcystin chemical variants many of which contain homophenylalanine or homotyrosine. We retrieved the complete 54.2 kb microcystin (mcy) gene cluster from a draft genome assembly. Analysis of the substrate specificity of McyB1 and McyC adenylation domain binding pockets revealed divergent substrate specificity …
Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.
2011
Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…
Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons
2010
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The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition.
2003
The cyclin-dependent kinase inhibitory protein p21(Cip1) might play multiple roles in cell-cycle regulation through interaction of its C-terminal domain with a defined set of cellular proteins such as proliferating cell nuclear antigen (PCNA), calmodulin (CaM), and the oncoprotein SET. p21(Cip1) could be described as an intrinsically unstructured protein in solution although the C-terminal domain adopts a well-defined extended conformation when bound to PCNA. However, the molecular mechanism of the interaction with CaM and the oncoprotein SET is not well understood, partly because of the lack of structural information. In this work, a peptide derived from the C-terminal domain of p21(Cip1) …