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Mājas daudzfunkcionālais serveris
2015
21.gadsimta mājās nekāds retums vairs nav viens vai divi datori. Katram ģimenes loceklim ir savs, vai pat divi datori, kas kalpo ikdienas darbu veikšanai, taču to savstarpējā komunicēšana un uzturēšana nevienmēr ir tas vieglākais darbs un var radīt pavisam lielas galvas sāpes mājas iedzīvotājiem, problēmu gadījumā. Pateicoties iespējai izveidot mājas serveri, ir iespējams nodrošināt vienu kopēju vietu iemītnieku datņu glabāšanai, kas paredz iespēju koplietot izvēlētos datus starp tiem savstarpēji, kā arī izveidot automatizācijas procesu datoru uzstādīšanai, lai pēc iespējas vairāk samazinātu patērēto laiku, sistēmu konfigurēšanai un uzturēšanai. Darba gaitā tiek izveidots multifunkcionāls m…
Mājas tīkla un servera izveide ar Windows Server 2016
2017
Kvalifikācijas darbā apskatītas mājsaimniecības privātā tīkla funkcionalitātes nepilnības un to risinājumu iespējas izmantojot izvēlēto sistēmu – Windows Server 2016. Darba mērķis ir uzlabot esošo LAN tīklu drošības un funkcionalitātes aspektā. Darba kontekstā risinātās problēmas ir aktuāls jautājums mūsdienu mājsaimniecībās, kur privāto tīklu veido vairāk kā 2-3 darbstacijas, mobilās iekārtas, tiek izmantota bezvadu piekļuve internetam un lietotāju starpā ir bērni. Darba teorētiskajā daļā veikta esošā mājas tīkla iekārtu un sistēmu izpēte, lai nodrošinātu piemērotākā risinājuma ieviešanu. Kā arī definēti darba gaitā izpildāmie uzdevumi, vadoties pēc lietotāju stāstiem. Darba praktiskajā da…
The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL…
2009
Abstract This paper shows that the histone deacetylase inhibitor SAHA sensitised at sub-toxic doses human hepatocellular carcinoma cells (HepG2, Hep3B and SK-Hep1) to TRAIL-induced apoptosis, while it was ineffective in primary human hepatocytes (PHHs). In particular in HCC cells SAHA increased the expression of death receptor 5 (DR5) and caused a decrement of c-Flip. These two modifications provoked in the presence of TRAIL the rapid production of TRAIL-DISC and the activation of caspase-8. Consequently SAHA/TRAIL combination induced many apoptotic events, such as a cleavage of Bid into tBid, dissipation of mitochondrial membrane potential, activation of caspase-3 with the consequent cleav…
CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells
2004
We investigated the membrane localization of CD95 in type I and type II cells, which differ in their ability to recruit and activate caspase-8. We found that CD95 was preferentially located in lipid rafts of type I cells, while it was present both in raft and non-raft plasma membrane sub-domains of type II cells. After stimulation, CD95 located in phospholipid-rich plasma membrane was recruited to lipid rafts in both types of cells. Similarly, CD95 cross-linking resulted in caspase-independent translocation of FADD/MORT1 and caspase-8 to the lipid rafts, which was prevented by a death domain-defective receptor. CD95 internalization was then rapid in type I and delayed in type II cells and s…
TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex
2021
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills various cancer cell types, but also leads to the activation of signaling pathways that favor resistance to cell death. Here, we investigated the as yet unknown roles of calcium signaling and autophagy regulatory proteins during TRAIL-induced cell death in leukemia cells. Taking advantage of the Gene Expression Profiling Interactive Analysis (GEPIA) project, we first found that leukemia patients present a unique TRAIL receptor gene expression pattern that may reflect their resistance to TRAIL. The exposure of NB4 acute promyelocytic leukemia cells to TRAIL induces intracellular Ca2+ influx through a calcium rel…
Leveraging a Wiki to EnhanceVirtual Collaboration in the Emergency Domain
2008
In a crisis situation, critical success factors include good preparedness, the availability of trustworthy information and reliable people, and the responders' ability to improvise with the available, functioning tools. Wikis can be used as collaborative group support systems to support these activities, especially for communities of practice that must operate as high reliability organizations. The advantages of using a wiki are especially beneficial in volatile environments, such as those in the emergency domain, where critical real-time decision making is required. An international wiki emergenciWiki.org - has been created and is being used by both practitioners and academics. The conclus…
Emergent vulnerabilities in Integrated Operations: A proactive simulation study of economic risk
2009
Abstract The protection of critical infrastructure requires an understanding of the effects of change on current and future safety and operations. Vulnerabilities may emerge during the rollout of updated techniques and integration of new technology with existing work practices. Managers need to understand how their decisions, often focused on economic priorities, affect the dynamics of vulnerability over time. Such understanding is difficult to obtain, as the historical data typically used for decision support, prediction and forecasting may not be available. We report on the use of group model building and simulation to consider proactively the effects of a 10-year, multi-billion dollar mo…
A Knowledge Based Decision Support System for Bioinformatics and System Biology
2011
In this paper, we present a new Decision Support System for Bioinformatics and System Biology issues. Our system is based on a Knowledge base, representing the expertise about the application domain, and a Reasoner. The Reasoner, consulting the Knowledge base and according to the user’s request, is able to suggest one or more strategies in order to resolve the selected problem. Moreover, the system can build, at different abstraction layers, a workflow for the current problem on the basis of the user’s choices, freeing the user from implementation details and assisting him in the correct configuration of the algorithms. Two possible application scenarios will be introduced: the analysis of …
Rough Set Theory for Supporting Decision Making on Relevance in Browsing Multilingual Digital Resources
2017
Browsing digital library (DL) collections seems to pose a challenge for a user owning to the number of factors like for instance, operability of the system, interface readability or clarity, and retrieval efficiency directly related to it, or the number of digital items within the user’s domain. However, when it comes to searching for an item in a foreign language to the user, the number of the factors arises even more which translates proportionally to the growing number of clicks aimed to retrieve the target item. Such a procedure usually leads to disheartening the user from browsing the digital collections. Our study into the user’s behavior interacting with multilingual DL system is set…
Towards the development of a Decision Support System (DSS) for building renovation: Domain Mapping Matrix (DMM) for sustainability renovation criteri…
2018
Future building renovation concerns more holistic perspectives related to the sustainability seen in a wider range of objectives/criteria facilitated by the renovation scenarios. In this regard, based on the studies upon existing sustainability evaluation and assessment tools carried out in previous research works, a characteristic diagram including a value map for evaluating a holistic sustainable retrofitting was developed. Further, in present paper, by reviewing the relevant literature, looking into recent European renovation research projects, the Danish SIGMA database, and investigation of a real case, a comprehensive list of renovation approaches (i.e. insulation technologies, windows…