Search results for "DOMAIN"
showing 10 items of 2485 documents
A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding.
1999
Interleukin (IL)-6, IL-11 and cililary neurotrophic factor (CNTF) belong to the same family of hematopoietic and neurotrophic cytokines. Their receptor complexes contain a cytokine-binding alpha receptor and the common glycoprotein (gp)130 subunit for signal transduction. The extracellular parts of the alpha-receptor subunits consist of a membrane-proximal cytokine-binding domain and an N-terminal immunoglobulin (Ig)-like domain with unknown function. We examined the role of the Ig-like domain of IL-6R by constructing deletion mutants lacking the Ig domain (IL-6RDeltaIg and soluble IL-6RDeltaIg). IL-6RDeltaIg was shed as effectively as wild-type IL-6R from transfected COS-7 cells upon 4beta…
Increased expression of the potential proapoptotic molecule DD2 and increased synthesis of leukotriene B4 during allograft rejection in a marine spon…
2000
Sponges (Porifera) are a classical model to study the events during tissue transplantation. Applying the 'insertion technique' autografts from the marine sponge Geodia cydonium fuse within 5 days. In contrast, allografts are rejected and destroyed. Here we show that during allograft rejection the cells in the grafts undergo apoptosis; 5 days after transplantation 46% of the cells show signs of apoptosis. In a previous study it was shown that during this process a tumor necrosis factor-like molecule is induced in allo- and xenografts. Molecules grouped to the superfamily of tumor necrosis factor receptors and a series of associated adapter molecules contain the characteristic death domain. T…
Robust Graph Topology Learning and Application in Stock Market Inference
2019
In many applications, there are multiple interacting entities, generating time series of data over the space. To describe the relation within the set of data, the underlying topology may be used. In many real applications, not only the signal/data of interest is measured in noise, but it is also contaminated with outliers. The proposed method, called RGTL, infers the graph topology from noisy measurements and removes these outliers simultaneously. Here, it is assumed that we have no information about the space graph topology, while we know that graph signal are sampled consecutively in time and thus the graph in time domain is given. The simulation results show that the proposed algorithm h…
Online mass flow prediction in CFB boilers with explicit detection of sudden concept drift
2010
Fuel feeding and inhomogeneity of fuel typically cause fluctuations in the circulating fluidized bed (CFB) process. If control systems fail to compensate the fluctuations, the whole plant will suffer from dynamics that is reinforced by the closed-loop controls. This phenomenon causes reducing efficiency and the lifetime of process components. In this paper we address the problem of online mass flow prediction, which is a part of control. Particularly, we consider the problem of learning an accurate predictor with explicit detection of abrupt concept drift and noise handling mechanisms. We emphasize the importance of having domain knowledge concerning the considered case and constructing the…
Domain separation for efficient adaptive active learning
2011
This paper proposes a procedure aimed at efficiently adapting a classifier trained on a source image to a similar target image. The adaptation is carried out through active queries in the target domain following a strategy particularly designed for the case where class distributions have shifted between the two images. We first suggest a pre-selection of candidate pixels issued from the target image by keeping only those samples appearing to be lying in a region of the input space not yet covered by the existing ground truth (source domain pixels). Then, exploiting a classifier integrating instance weights, active queries are performed on the target image. As the inclusion to the training s…
Análisis del proceso migratorio de las familias colombianas en España
2014
espanolSe analiza la migracion como proceso centrado en la familia transnacional, segun relato de sus protagonistas: migrantes - padres e hijos - y familiares en Colombia. Se parte del modelo sistemico y de la metodologia de la Grounded-Theory. El proceso se desencadena por una combinacion de factores de empuje y de llamada; los pioneros, mayoritariamente mujeres, poseen un perfil muy variado. Destaca la dificultad de sus primeras experiencias, que mejoran gracias a sus apoyos externos y a su teson. A pesar de las dificultades del proceso de aculturacion, el balance realizado es positivo, sobre todo por la esperanza puesta en los hijos, que tras las dificultades iniciales desean permanecer …
Closed Theories, Falsificationism and Non-Cumulative Progress
2020
It is argued that scientific progress occurs not with the cumulative growth of knowledge or when theories get closer to the truth but with discovering new domains and new theories that fit these domains. This horizontal view on the direction of scientific progress (in contrast to vertical, when we aim to get from here to the abstract and ephemeral truth) allows avoiding traditional objections posed by the incommensurability thesis and pessimistic induction, namely, that radical theory changes leave no room for progress. According to this perspective, the discovery of quantum mechanics as a new field of inquiry is a progress in itself, since this discovery had opened up a new distinctive dom…
Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence.
2013
8-Oxoguanine (8-oxoG) is a major product of oxidative DNA damage, which induces replication errors and interferes with transcription. By varying the position of single 8-oxoG in a functional gene and manipulating the nucleotide sequence surrounding the lesion, we found that the degree of transcriptional inhibition is independent of the distance from the transcription start or the localization within the transcribed or the non-transcribed DNA strand. However, it is strongly dependent on the sequence context and also proportional to cellular expression of 8-oxoguanine DNA glycosylase (OGG1)-demonstrating that transcriptional arrest does not take place at unrepaired 8-oxoG and proving a causal…
8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1.
2011
The common DNA base modification 8-oxo-7,8-dihydroguanine (8-oxo-G) affects the efficiency and fidelity of transcription. We constructed plasmid substrates carrying single 8-oxo-G residues, specifically positioned in the transcribed or the non-transcribed DNA strands, to investigate their effects on the expression of an EGFP reporter gene and to explore the role of base excision repair in the mechanism of transcription inhibition. We report that 8-oxo-G does not directly block transcription in cells, since a single 8-oxo-G in the transcribed DNA strand did not reduce the EGFP expression levels in repair-deficient (OGG1-null) mouse embryonic fibroblast cell lines. Rather, inhibition of trans…
On the relation between present and future tense in Lithuanian: Preliminary considerations in the domain of non-deictic tense use
2021
The article examines non-deictic uses of present and future tense in Lithuanian. Narrative use, in which reference intervals match with singular events, is distinguished from suspended propositions characterized by lack of such reference intervals (habitual, dispositional and circumstantial modal, and conditional meanings). Present tense is frequently involved in both usage domains, while the future is rare in narrative use, but overlaps with present tense in certain types of suspended propositions. Moreover, its temporal-deictic use is inherently associated with suspended propositions and “linked” to them via epistemic implicatures. This, in contrast to the present, makes the future more l…