Search results for "DOMAINS"
showing 9 items of 269 documents
α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation
2009
The Swedish mutation within the amyloid precursor protein (APP) causes early-onset Alzheimer's disease due to increased cleavage of APP by BACE1. While beta-secretase shedding of Swedish APP (APPswe) largely results from an activity localized in the late secretory pathway, cleavage of wild-type APP occurs mainly in endocytic compartments. However, we show that liberation of Abeta from APPswe is still dependent on functional internalization from the cell surface. Inspite the unchanged overall beta-secretase cleaved soluble APP released from APP(swe) secretion, mutations of the APPswe internalization motif strongly reduced C99 levels and substantially decreased Abeta secretion. We point out t…
<p>Barriers and enablers to the implementation of perioperative hypothermia prevention practices from the perspectives of the multidisciplinary…
2019
Judy Munday,1,2 Alana Delaforce,1,3 Gillian Forbes,4 Samantha Keogh11School of Nursing and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia; 2Department of Health and Nursing Science, University of Agder, Grimstad, Norway; 3Clinical Governance Unit, Mater Health, South Brisbane, QLD 4101, Australia; 4Department of Clinical, Educational and Health Psychology, UCL Centre for Behaviour Change, London WC1E 6BT, UKPurpose: Inadvertent perioperative hypothermia is a significant problem for surgical patients globally, and is associated with many detrimental side-effects. Despite the availability of rigorously developed internatio…
Isolation of Four Lytic Phages Infecting Klebsiella pneumoniae K22 Clinical Isolates from Spain
2020
This article belongs to the Special Issue Bacteriophage—Molecular Studies.
Lenses on very curved zones of a singular line field of ${\mathbb C}^2$ or of a singular plane field of ${\mathbb C}^3$
2020
We renormalize, using suitable lenses, small domains of a singular holomorphic line field of ${\mathbb C}^2$ or plane field of ${\mathbb C}^3$ where the curvature of a plane-field is concentrated. At a proper scale the field is almost invariant by translations. When the field is integrable, the leaves are locally almost translates of a surface that we will call {\it profile}. When the singular rays of the tangent cone (a generalization to a plane-field of the tangent cone of a singular surface is defined) are isolated, we obtain more precise results. We also generalize a result of Merle (\cite{Me}) concerning the contact order of generic polar curves with the singular level $f=0$ when $\ome…
Domini collettivi, forme di autogoverno per la gestione degli ecosistemi e lo sviluppo locale
2020
One of the most ancient forms of self-government of environmental systems is that relating to the management of civic uses and collective lands, in which a specific local community controls and manages sustainable resources (fields, pastures, woods, etc.) sustainably and efficiently. The paper aims to briefly retrace the salient stages of the history of collective domains, and to explore their value as “goods that are produced by long co-evolutionary processes between human settlement and environment” (Magnaghi 2015, 139) highlighting the appearance of complex socio-ecological systems (SES). Finally, using the theory developed by Elinor Ostrom to analyze the sustainability of SES (Ostrom 20…
Evaluation of web reinforcements in prestressed concrete box girders through shear-transverse bending domains
2020
In concrete box girders, the amount and distribution of reinforcements in the webs have to be estimated considering the local effects due to eccentric external loads and cross-sectional distortion and not only the global effect due to the resultant forces of a longitudinal analysis: shear, torsion and bending. This work presents an analytical model that allows designers to take into account the interaction of all these effects, global and local, for the determination of the reinforcements. The model is based on the theory of stress fields and it has been compared to a 3D finite element analysis, in order to validate the interaction domains. The results show how the proposed analytical mode…
No Safe Haven for Truth Pluralists
2021
Truth pluralism offers the latest extension in the tradition of substantive theorizing about truth. While various forms of this thesis are available, most frameworks commit to domain reliance. According to domain reliance, various ways of being true, such as coherence and correspondence, are tied to discourse domains rather than individual sentences. From this follows that the truth of different types of sentences is accounted for by their domain membership. For example, sentences addressing ethical matters are true if they cohere and those addressing extensional states of affairs if they correspond. By tying distinct truth-grounding properties to domains rather than individual sentences, t…
Human Papillomavirus Types 16, 18, and 31 Share Similar Endocytic Requirements for Entry
2013
ABSTRACT Human papillomavirus type 18 (HPV18), one of the HPVs with malignant potential, enters cells by an unknown endocytic mechanism. The key cellular requirements for HPV18 endocytosis were tested in comparison to those for HPV16 and -31 endocytoses. HPV18 (like HPV16 and -31) entry was independent of clathrin, caveolin, dynamin, and lipid rafts but required actin polymerization and tetraspanin CD151, and the viruses were routed to the same LAMP-1-positive compartment. Hence, the viruses shared similar cellular requirements for endocytic entry.
Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16—Involvement of Tetraspanin-Enriched Microdomains (TEMs)
2008
BACKGROUND: Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. METHODOLOGY/PRINCIPAL FINDINGS: Using immunofluorescence and infection studies we show in contra…