Search results for "DOP"
showing 10 items of 4870 documents
Massoneria
2005
Il processo di rinnovamento interno avviato da una parte della massoneria italiana dopo l’emanazione della legge 25 gennaio 1982 n. 17 (Norme di attuazione dell’art. 18 della Costituzione in materia di associazioni segrete e scioglimento dell’associazione denominata Loggia P2) e dopo la promulgazione della nuova Costituzione dell’Ordine, firmata da Armando Corona il 18 novembre del 1984, attraversa – ancora oggi – un percorso tortuoso, travagliato e complesso. Del resto, articolata e complessa è stata, nel nostro Paese, la storia della libera muratoria, che dal dopoguerra ai giorni nostri, a più riprese, oltre a divisioni e contrasti interni, ha dovuto registrare episodi gravi di “deviazion…
TERMODINAMICA, CAMPI QUANTICI E FUNZIONI MENTALI
2010
Nel tentativo di fornire spiegazioni esaurienti sul fenomeno della mente umana, il presente saggio scientifico di anatomia comparata e di fisiologia considera alcune tesi di fondo che si collegano a nuovi parametri fisici della realtà che ci circonda.
Victim to Victimizer: The Psychology of Isomorphism in a Case of a Recidivist Pedophile in Finland
1999
ABSTRACT An extreme case of a six victim, 38-year-old recidivist sex offender was selected for examining the isomorphic relationships between child sexual abuse trauma and adult sex offenses. This sex offender had victimized children of both sexes and an adult woman. Life history, letter, file, and the Adult Attachment Interview information were analyzed to seek the relations between childhood abuse experiences and adult offending. Both subjective reports and file data revealed that the man had experienced severe physical, psychological, and sexual abuse in childhood. His pattern of sexual offending against children was similar to his own experiences of sexual abuse by his father. The age o…
Sexual Selection Within the Female Genitalia in Lepidoptera
2015
The genitalia of male and female Lepidoptera are complex organs, composed of several structures that exhibit great diversity of shapes, sizes, and positions, suggesting that they have evolved in a relatively rapid and divergent way. In this chapter, we explore the selective pressures responsible for the evolution of genital morphology in the Lepidoptera , emphasizing the possible role of post-copulatory intersexual selection (PCIS) mechanisms (cryptic female choice and sexual conflict). Our exploration is in great extent speculative because knowledge on the functional morphology of genitalia in this group is limited. We start by describing the complexity and diversity of genitalia in Lepido…
Surface sediment dynamics along the Tunisian coast at Skhira (Gulf of Gabès, south-eastern Tunisia)
2015
Abstract An investigation was conducted in the summer of 2012 at 24 study stations along the Tunisian coast near Skhira (south-eastern Mediterranean Sea) through high resolution of analyses, grain size and mineral composition of surface sediment. An Acoustic Doppler Current Profiler showed Skhira's main coastal current to follow a direction 60°E, with its main axis south-west/north-east parallel to the coastline and its minor axis east-west. Current speeds were approximately 13 cm s−1 and 4.5 cm s−1 for the major and minor axes, respectively. Parallel to the coast, currents were generally mild to moderate, but often exceeded 20 cm s−1. An Argonaut meter recorded the dominant current directi…
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
2000
The melanosomal protein tyrosinase is considered as a target of specific immunotherapy against melanoma. Two tyrosinase-derived peptides are presented in association with HLA-A2.1 [Wolfel et al., Eur. J. Immunol., 24, 759-764 (1994)]. Peptide 1-9 (MLLAVLYCL) is generated from the putative signal sequence. The internal peptide 369-377 is posttranslationally converted at residue 371, and its presentation is dependent on functional TAP transporters and proteasomes [Mosse et al., J. exp. Med.187, 37-48 (1998)]. Herein, we report on the processing and transport requirements for the signal sequence-derived peptide 1-9 that were studied in parallel to those for peptide 369-377. After infection of …
The microsomal epoxide hydrolase has a single membrane signal anchor sequence which is dispensable for the catalytic activity of this protein
1994
The microsomal epoxide hydrolase (mEH) catalyses the hydrolysis of reactive epoxides which are formed by the action of cytochromes P-450 from xenobiotics. In addition it has been suggested that mEH might mediate the transport of bile acids. For the mEH it has been shown that it is co-translationally inserted into the endoplasmic reticulum. Here we demonstrate that the N-terminal 20 amino acid residues of this protein serve as its single membrane anchor signal sequence and that the function of this sequence can also be supplied by a cytochrome P-450 (CYP2B1) anchor signal sequence. The evidence supporting this conclusion is as follows: (i) the rat mEH and a CYP2B1-mEH fusion protein, in whic…
Sequence of the M28 dsRNA: Preprotoxin Is Processed to an α/β Heterodimeric Protein Toxin
1995
The killer and immunity phenotypes of K28 killer strains of Saccharomyces cerevisiae are determined by the 1.75-kb M28 dsRNA virus. In the plus strand, M28p, the K28 preprotoxin gene, comprises bases 13-1047 and is followed, after an additional 85 bases, by a 63-bp poly(A) sequence and a 553-base 3'-sequence. This 3'-sequence contains two potential stem-loop structures predicted to bind the L-A encoded cap-pol protein, initiating encapsidation; high-level expression results in curing of M1 dsRNA. Expression of M28p confers the complete K28 killer and immunity phenotype on a cell lacking M28 dsRNA. K28 toxin is a disulfide-bonded heterodimer of alpha (10.5 kDa) and beta (11 kDa) components w…
mp23, a Theileria parva transmembrane protein with homology to the protein disulfide isomerase family
2002
The protozoan parasite Theileria parva (Apicomplexa) causes the bovine disease East Coast Fever in endemic areas in Subsaharan Africa. The intralymphocytic schizont stage is largely responsible for the pathogenicity and induces a transformed phenotype in host cells [1]. Current evidence supports a model in which the schizont perturbs the immune response by inducing production of cytokines and stimulating the growth of parasitized cells [2]. We were interested to identify parasite proteins involved in parasite/host interaction and have described earlier a screening procedure for identification of schizont stage-exported proteins based on cell-free expression of cDNA and testing for transloca…
AtPGAP1 functions as a GPI inositol-deacylase required for efficient transport of GPI-anchored proteins
2021
Abstract Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) play an important role in a variety of plant biological processes including growth, stress response, morphogenesis, signaling, and cell wall biosynthesis. The GPI anchor contains a lipid-linked glycan backbone that is synthesized in the endoplasmic reticulum (ER) where it is subsequently transferred to the C-terminus of proteins containing a GPI signal peptide by a GPI transamidase. Once the GPI anchor is attached to the protein, the glycan and lipid moieties are remodeled. In mammals and yeast, this remodeling is required for GPI-APs to be included in Coat Protein II-coated vesicles for their ER export and subsequent t…