Search results for "DOP"
showing 10 items of 4870 documents
Recombinant NeutraLite Avidin: a non-glycosylated, acidic mutant of chicken avidin that exhibits high affinity for biotin and low non-specific bindin…
2000
AbstractA recombinant non-glycosylated and acidic form of avidin was designed and expressed in soluble form in baculovirus-infected insect cells. The mutations were based on the same principles that guided the design of the chemically and enzymatically modified avidin derivative, known as NeutraLite Avidin. In this novel recombinant avidin derivative, five out of the eight arginine residues were replaced with neutral amino acids, and two of the lysine residues were replaced by glutamic acid. In addition, the carbohydrate-bearing asparagine-17 residue was altered to an isoleucine, according to the known sequences of avidin-related genes. The resultant mutant protein, termed recombinant Neutr…
Das kompositorische Verfahren in Jean Moutons Quadrupelkanon Nesciens mater virgo virum
2012
Anhand der kompositorischen Probleme, die sich bei der Konzeption mehr als zweistimmiger Kanons ergeben, wird der Frage nachgegangen, wie der konkrete Kompositionsprozess um 1500 ausgesehen haben konnte. Eine Analyse von Jean Moutons Motette Nesciens mater zeigt, dass die Wechselwirkungen zwischen Kanonkonzeption, Klangfolge und melodischer Gestaltung eine simultane Kompositionsweise voraussetzen, in der die Klangfolge wechselnde Verhaltnisbestimmungen als Resultat und Voraussetzung der kontrapunktischen Konfiguration erfahrt: Der Wechsel von der Sukzessiv- zur Simultankonzeption erscheint in Bezug auf komplexe Kanonbildungen als ein verfahrenstechnisches Erfordernis.
30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed into the Developmental Risk Factor Model of Psychosis
2017
At its re-birth 30 years ago, the neurodevelopment hypothesis of schizophrenia focussed on aberrant genes and early neural hazards, but then it grew to include ideas concerning aberrant synaptic pruning in adolescence. The hypothesis had its own stormy development and it endured some difficult teenage years when a resurgence of interest in neurodegeneration threatened its survival. In early adult life, it over-reached itself with some reductionists claiming that schizophrenia was simply a neurodevelopmental disease. However, by age 30, the hypothesis has matured sufficiently to incorporated childhood and adult adversity, urban living and migration, as well as heavy cannabis use, as importan…
Stimulant-induced adaptations in neostriatal matrix and striosome systems: Transiting from instrumental responding to habitual behavior in drug addic…
2005
Abstract Converging evidence indicates that repeated exposure to motor stimulants such as cocaine and amphetamine produces marked alterations in network responsiveness of striatal neurons to subsequent challenge with the same stimulant drug. Such alterations, which correlate with persistent patterns of repetitive behavior, associate with distinct compartmental changes in the neostriatum. Striatal matrix system neurons undergo “silencing” following repeated drug challenges, allowing striosome system neurons to exhibit preferential activation. Matrix neurons are innervated by sensory and motor areas of neocortex and are activated in the course of on-going, adaptive behavior. Inactivation of m…
Erratum to “Cerium effect on the phase structure, phase stability and redox properties of Ce-doped strontium ferrates”
2008
Use of middle cerebral velocity and blood pressure for the analysis of cerebral autoregulation at various frequencies: The coherence index
1998
A common component in many protocols for the evaluation of cerebral autoregulation is the comparison of transcranial Doppler ultrasound (TCD) velocities with blood pressure recordings, in which correlations between these two signals correspond to impaired autoregulation. With long data sets and complicated paradigms, however, visual inspection alone cannot adequately distinguish random coincidence from consistent correlation in a statistically valid fashion. We suggest and illustrate the use of the coherence index for this purpose. To illustrate this technique, long-term recordings of TCD velocity and blood pressure were obtained from 6 normal subjects and using 23 data segments from 8 pati…
Gūžas locītavas osteoartrīta ārstēšanas rezultātu analīze pirmajā mēnesī pēc totālās endoprotezēšanas
2019
Darba mērķis: salīdzināt pacientu dzīves kvalitāti (fiziskas spējas, spēju atgriezties pie normāla dzīvesveida) pacientiem pirms un pēc totālas gūžas endoprotēzēšanas izmantojot adaptētu latviešu un krievu valodā HOOS (Hip disability and osteoarthritis outcome score) aptauju. Pētāmais jautājums: Vai gūžas endoprotezēšanas operācijas pacientiem ar gūžas osteoartrītu mazina ar artrītu saistītus simptomus, aktivitāšu ierobežojums un dzīves kvalitāti jau pirmajā mēnesī pēc operācijas? Darba teorētiskajā daļā tika apkopota informācija par gūžas locītavas anatomijas īpatnībām, gūžas osteoartrīta cēloņiem, klīniskām manifestācijam, patoģenēzi un ārstēšanas iespējām, kā arī pār operācijas procedūru…
Lesions of the dopaminergic innervation of the nucleus accumbens medial shell delay the generation of preference for sucrose, but not of sexual phero…
2011
Male sexual pheromones are rewarding stimuli for female mice, able to induce conditioned place preference. To test whether processing these natural reinforcing stimuli depends on the dopaminergic innervation of the nucleus accumbens, as for other natural rewards, we compare the effects of specific lesions of the dopaminergic innervation of the medial shell of the nucleus accumbens on two different appetitive behaviours, ‘pheromone seeking’ and sucrose preferential intake. Female mice, with no previous experience with either adult male chemical stimuli or with sucrose, received injections of 6-hydroxydopamine (or vehicle) in the medial shell of the accumbens. Then, we analyzed their preferen…
Light-driven proton transport of bacteriorhodopsin incorporated into long-term stable liposomes of a polymerizable sulfolipid
1983
Abstract The chromoprotein bacteriorhodopsin from Halobacterium halobium has been incorporated into liposomes made of a fully synthetic, polymerizable lipid. Bacteriorhodopsin is found to be active in these polymer liposomes. The advantage in the use of such polymer systems concerning long-term stability in comparison with liposomes made of natural lipid is demonstrated.
Effect of boron doping in the microwave surface resistance of neutron irradiated melt-textured Y1.6Ba2.3Cu3.3O7−x samples
2012
We report on the microwave surface resistance of melt-textured Y_1.6Ba_2.3Cu_3.3O_7-x samples, doped with different amount of B_2O_3 and, subsequently, irradiated by thermal neutrons at the fluence of 1.476 \times 10^17 cm^-2. The microwave surface resistance has been measured as a function of temperature and DC magnetic field. The experimental results are quantitatively discussed in the framework of the Coffey and Clem theory, properly adapted to take into account the d-wave nature of cuprate superconductors. By fitting the experimental data at zero DC field, we have highlighted the effects of the induced defects in the general properties of the samples, including the intergranular region.…