Search results for "DOP"
showing 10 items of 4870 documents
Neuropeptidome regulation after baculovirus infection. A focus on proctolin and its relevance in locomotion and digestion
2020
AbstractBaculoviruses constitute a large group of invertebrate DNA viruses, predominantly infecting larvae of the insect order Lepidoptera. During a baculovirus infection, the virus spreads throughout the insect body producing a systemic infection in multiple larval tissues. Some behavioral and physiological changes in lepidopteran larvae have been described following a baculovirus infection and those changes could be connected with alterations in the host’s central nervous system (CNS). As a main component of the CNS, neuropeptides are small protein-like molecules functioning as neurohormones, neurotransmitters or neuromodulators. These peptides are involved in regulating animal physiology…
A proctolin-like peptide is regulated after baculovirus infection and mediates in caterpillar locomotion and digestion
2022
Baculoviruses constitute a large group of invertebrate DNA viruses, predominantly infecting larvae of the insect order Lepidoptera. During a baculovirus infection, the virus spreads throughout the insect body producing a systemic infection in multiple larval tissues, included the central nervous system (CNS). As a main component of the CNS, neuropeptides are small protein-like molecules functioning as neurohormones, neurotransmitters, or neuromodulators. These peptides are involved in regulating animal physiology and behavior and could be altered after baculovirus infection. In this study, we have investigated the effect of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) infection …
Gūžas locītavas endoprotezēšanas radioloģiskais novērtējums pēc operācijas
2015
Gūžas locītavas totāla endoprotezēšana ir viena no visaktuālākajām operācijām traumatoloģijā un ortopēdijā, kura, šodien, nav iedomājama bez preoperatīvas radioloģiskās operāciju plānošanas un postoperatīvas radioloģiskas novērtēšanas. Šī reparatīvā metode dod pacientiem iespēju atgūt locītavas funkcionālās spējas, pārvietoties bez sāpēm un uzlabo dzīves kvalitāti. Savukārt dislokācija pēc totālas gūžas locītavas endoprotezēšanas operācijas ir viena no būtiskajām un aktuālajām problēmām, kura skar gan pacientu, gan ārstu, gan veselības sistēmu kopumā. Pētījuma mērķis un zinātniskais jautājums ir - noteikt vai acetabulārie komponenti, kurus implantē VSIA „Traumatoloģijas un ortopēdijas slimn…
LA NORMATIVA PENALISTICA ANTIDOPING E LO SPORT AMATORIALE: IL VULNUS AL DIRITTO FONDAMENTALE ALLA SALUTE
2015
Síntesis de nuevas isoquinoleínas 1-sustituidas con actividad antibacteriana y antifúngica o dopaminérgica
2015
La Naturaleza ha proporcionado durante décadas una ingente cantidad de metabolitos secundarios activos (MSA) con muy diversas aplicaciones terapéuticas. Durante décadas, nuestro grupo de investigación se ha centrado tanto en el aislamiento de MSA de plantas pertenecientes a la familia de las Annonáceas como en el desarrollo de análogos estructurales de algunos MSA, especialmente acetogeninas y alcaloides isoquinoleínicos, que pudieran ser biológicamente activos. Considerando estos hechos se propuso en la presente Tesis Doctoral la consecución de los siguientes objetivos: 1- Estudio de los distintos tipos de MSA presentes en Annonáceas que han servido de inspiración para el desarrollo de nue…
Nuevos fármacos inspirados en Annonáceas
2014
Los metabolitos secundarios activos (MSA) juegan un papel importante en el descubrimiento de nuevos medicamentos. Moléculas naturales con esqueletos complejos, tales como las estatinas aisladas de Aspergillus terreus, o las acetogeninas específicas de la familia Annonaceae, no hubieran podido ser inventadas en ningún laboratorio. Los MSA aislados en Annonaceae, especialmente las acetogeninas y los alcaloides isoquinoleínicos, pueden ser considerados como fuente constante de inspiración para químicos, farmacólogos y para todos los investigadores interesados en el descubrimiento de una nueva familia de medicamentos. Active secondary metabolites (ASM) play a highly significant role in the drug…
Antioxidative and Photo-Induced Effects of Different Types of N-Doped Graphene Quantum Dots.
2022
Due to the increasing number of bacterial infections and the development of resistivity toward antibiotics, new materials and approaches for treatments must be urgently developed. The production of new materials should be ecologically friendly considering overall pollution with chemicals and economically acceptable and accessible to the wide population. Thus, the possibility of using biocompatible graphene quantum dots (GQDs) as an agent in photodynamic therapy was studied. First, dots were obtained using electrochemical cutting of graphite. In only one synthetic step using gamma irradiation, GQDs were doped with N atoms without any reagent. Obtained dots showed blue photoluminescence, with…
Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.
2008
Background & Aims Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-β signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-β signaling is impaired because of high expression of the inhibitory molecule Smad7. Although no intrinsic defects in Tregs function have been shown in IBD, it is still unknown whether colitogenic T cells are susceptible to Treg-mediated suppression. In this study, we have investigated whether IBD mucosal CD4+ T cells are resistant to Tregs and whether Smad7 is involved in this process. Methods IBD lamina propria mononuclear cells …
Reduction in site fidelity with smaller spatial scale may suggest scale-dependent information use
2014
Animals change the strategy that they use to select breeding sites at the spatial scales of habitat, patch, and microhabitat. In this regard, breeding site fidelity is expected to vary according to environmental predictability, which, in turn, is expected to differ between each spatial scale. However, whether or not animals change their degree of site fidelity at different spatial scales remains unclear. We captured and released males of the terrestrial frog Pseudophryne bibronii into alternative patches within a breeding habitat and determined the extent to which site fidelity influenced individual nest-site choice. We found that males tended to return to their original patch rather than r…
The Putative Metal Coordination Motif in the Endonuclease Domain of Human Parvovirus B19 NS1 Is Critical for NS1 Induced S Phase Arrest and DNA Damage
2011
The non-structural proteins (NS) of the parvovirus family are highly conserved multi-functional molecules that have been extensively characterized and shown to be integral to viral replication. Along with NTP-dependent helicase activity, these proteins carry within their sequences domains that allow them to bind DNA and act as nucleases in order to resolve the concatameric intermediates developed during viral replication. The parvovirus B19 NS1 protein contains sequence domains highly similar to those previously implicated in the above-described functions of NS proteins from adeno-associated virus (AAV), minute virus of mice (MVM) and other non-human parvoviruses. Previous studies have show…