Search results for "DORSAL"

A cerebral nitrergic pathway modulates endotoxin-induced changes in gastric motility

2001

1 This study analyses the neural pathway involved in the modulation of gastric motor function by stress. 2 Systemic administration of low doses of endotoxin (40 m gk g 71 , i.v.) prevents the increase in gastric tone induced by 2-deoxy-D-glucose (200 mg kg 71 , i.v., 2-DG) in urethane-anaesthetized rats. 3 Functional inhibition of aAerent neurones by systemic administration of capsaicin (20+30+50 mg kg 71 , i.m.) in adult rats prevented the inhibitory eAects of endotoxin. 4 Pre-treatment with the nitric oxide synthase (NOS) inhibitor, N G -nitro-L-arginine methyl ester (LNAME), both i.v. (10 mg kg 71 ) and i.c. (200 mg rat 71 ), prevented the inhibitory eAects of endotoxin on gastric tone i…

Symmetry Breaking and Establishment of Dorsal/Ventral Polarity in the Early Sea Urchin Embryo

2015

The mechanisms imposing the Dorsal/Ventral (DV) polarity of the early sea urchin embryo consist of a combination of inherited maternal information and inductive interactions among blastomeres. Old and recent studies suggest that a key molecular landmark of DV polarization is the expression of nodal on the future ventral side, in apparent contrast with other metazoan embryos, where nodal is expressed dorsally. A subtle maternally-inherited redox anisotropy, plus some maternal factors such as SoxB1, Univin, and p38-MAPK have been identified as inputs driving the spatially asymmetric transcription of nodal. However, all the mentioned factors are broadly distributed in the embryo as early as no…

Acute and chronic pain

2017

Acute or chronic pain is a complex multidimensional neuronal response that draws attention to damaging or potentially damaging situations. A complex cascade of events takes place between the triggering occurrence of irritation and the final result of pain perception. In the beginning the nociceptor transforms the noxious threat into a signal.

Serotonergic versus non-serotonergic dorsal raphe projection neurons differential participation in reward circuitry

ROLE OF DORSAL RAPHE NUCLEUS AND VENTRAL TEGMENTAL AREA ON REWARD AND FEEDING BEHAVIORS IN MICE

Spinothalamic and thalamocortical nociceptive pathways

2002

The concept that the perception of a stimulus as being painful requires activity in parts of the cerebral cortex has gained universal recognition within the past 10 years. 28 The large number of functional imaging studies in humans, appearing during that period, have greatly contributed to this development by showing consistent evidence for activation of various cortical areas by painful stimuli, including the primary and secondary somatosensory cortex, the insula, the anterior cingulate gyrus, and prefrontal cortical areas. Thus, the sense of pain—like all other senses— has a representation within the cerebral cortex. These imaging studies, however, did not reveal the pathways by which a p…

Central Serotonin2C Receptor: From Physiology to Pathology

2006

Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions. Although 5-HT is synthesized by a small group of neurons within the raphe nuclei of the brain stem, almost all parts of the CNS receive serotonergic projections. Furthermore, the importance of 5-HT modulation and the fine-tuning of its action is underlined by the large number of 5-HT binding sites found in the CNS. Hitherto, up to 15 different 5-HT receptors subtypes have been identified. This review was undertaken to summarize the work that has…

Meristic character counts and incidence of skeletal anomalies in the wild Diplodus puntazzo (Cetti, 1777) of an area of the south-eastern Mediterrane…

2006

The sharpsnout seabream (Diplodus puntazzo, Cetti 1777) is a species rarely found in coastal areas of Sicily, but is important in Mediterranean aquaculture. In order to detect the number of meristic characters and the main types of body deformation, 588 specimens of sharpsnout seabream were collected from a coastal zone of south-east Sicily (Licata, AG—Italy). Different sized classes were examined and the relationship between size and the number of meristic characters (number of fin rays) was found. The number of vertebrae, anal fin hard rays and dorsal fin hard rays was constant and did not vary with size. Seventeen types of skeletal and fin anomalies were observed, but no grave anomalies …

Dorsal/Ventral asymmetric expression of nodal in the early sea urchin embryo relies on specific suppression in dorsal cells by the Hbox12 homeodomain…

2014

Dorsal/Ventral (DV) polarization of the sea urchin embryo is directed by a Nodal-expressing signaling centre located on the ventral side. The initial breaking of the symmetry and positioning of the organizer are unclear. We show that, in Paracentrotus lividus embryos, the Hbox12 homeodomaincontaining repressor is expressed on the opposite side and precedes the onset of nodal transcription. Hbox12 misexpression provokes DV abnormalities, attenuating nodal and nodal-dependent gene transcription. Reciprocally, clonal hbox12 loss-of-function imposed by blastomere transplantation or gene transfer assays disrupts DV polarization and allows ectopic expression of nodal. Remarkably, the localized kn…

Suppression of nodal expression in prospective dorsal cells of the early sea urchin embryo by the hbox12 homeodomain regulator

2014

Dorsal/Ventral (DV) axis formation in the sea urchin embryo depends upon the expression of nodal on the ventral side, which behaves as a DV organizing centre. However, only fuzzy clues are known as to the early symmetry-breaking steps that lead to the positioning of such an organizer. An extremely interesting candidate for this role is the hbox12 homeobox-containing gene. In Paracentrotus lividus, hbox12 expression is antecedent and complementary with respect to that of nodal, being confined in prospective dorsal cells. We show that ectopic expression of Hbox12 provokes DV abnormalities and attenuates nodal as well as nodal-dependent gene transcription. By blastomere transplantation, we als…