Search results for "DOT"

Quando recte consideratur de contractione, omnia sunt clara. Singolarità e finalità nel De docta ignorantia di Nicola Cusano

2008

Muovendo da un confronto con la successiva e affine dialettica della contrazione formulata da Giordano Bruno, il saggi focalizza l’impianto teorico del De docta ignorantia (1440) di Nicola Cusano, mirando a delineare per questa via il nucleo teorico fondamentale dell’elaborazione cusaniana, gravitante intorno ai temi dell’unità del principio, della sua struttura trinitaria, e del suo dispiegarsi al di fuori di sé nella varietà della manifestazione. Il saggio propone la tesi della continuità e coerenza dell’itinerario cusaniano come rimodulazione continua del capolavoro del 1440, misurandosi con la posizione divergente di Hans Blumenberg, che in continuità con un diffuso orientamento storiog…

Efavirenz induces interactions between leucocytes and endothelium through the activation of Mac-1 and gp150,95

2013

The potential cardiovascular (CV) toxicity associated with combined antiretroviral therapy (cART) has been attributed mainly to the nucleoside reverse transcriptase inhibitors abacavir and didanosine. However, the other two components of cART--non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs)--may also be implicated, either directly or by influencing the action of the other drugs. This study evaluates the acute direct effects of the NNRTIs efavirenz and nevirapine and one of the most widely employed PIs, lopinavir, on leucocyte-endothelium interactions, a hallmark of CV disease.Drugs were analysed in vitro in human cells (interactions of peripheral blood…

Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells.

1994

SUMMARY Autoantibodies directed against cytoplasmic antigens of neutrophils (ANCA), especially those with specificity for proteinase 3 (PR-3) and myeloperoxidase, are valuable markers for differential diagnosis and monitoring of disease activity in Wegener's granulomatosis (WG) and other vasculitides. Till now, several concepts concerning a direct role of antibodies against PR-3 in the pathogenesis of WG have been discussed. Recently we were able to show that these antibodies recognize PR-3 translocated into the membrane of human endothelial cells. The aim of this study was to investigate putative cytotoxic effects of antibodies to PR-3 on human endothelial cells. Antibodies were obtained b…

Heat shock protein-antigen fusions lose their enhanced immunostimulatory capacity after endotoxin depletion.

2008

Heat shock proteins (HSPs) induce cross-presentation of antigens by dendritic cells (DC) as well as DC maturation. These properties make HSP antigen complexes good candidates to prime CD8 T cell responses against tumor-associated antigens. In this study, we analyzed four different members of the HSP70 family fused to a fragment of ovalbumin (OVA) as a model tumor antigen. E. coli-derived recombinant HSP70-OVA fusion proteins efficiently primed antigen-specific cytotoxic T cells in short-term in vivo immunization assays. Because of concerns that the adjuvant effect of HSPs may be due to endotoxin contamination, we studied this issue in detail. Induction of OVA-specific cytotoxicity was signi…

Impact des allocations en ressources sur l'efficacité des écoles primaires en Côte d'Ivoire

2011

The quality of primary education in Côte d'Ivoire has deteriorated sharply over the past three decades. This situation is the result of an approximate management of the education system, which is characterized by a lack of educational support, a misallocation of resources, a congestion of classrooms (42 students for a teacher in primary school) and a lack of skilled and well trained teachers. In addition, the military-political conflict in September 2002 did not allow to improve this situation; on the contrary, it has further deteriorated the situation. Thus, the aim of this thesis is first to analyze the influence of resource endowments on the effectiveness of primary schools in Cote d'Ivo…

FINE STRUCTURE OF THE ABSORBING LYMPHATIC VESSEL AND INTRAVASATION MODALITY OF THE CANCER CELL

2007

The topografic distribution and the fine structure of the tumor-associated absorbing lymphatic vessel in the B16 Melanoma and T84 adenocarcinoma subcutaneous tumor mass of nude mice and in adenocarcinoma mouse prostate in transgenic mice were studied to demonstrate the modality of the cancer cell transendothelial migration and the role of the lymphatic pathway in the metastatic diffusion. Furthermore, the structural characteristics of the lymphatic vascular system canalisation, that allow to discriminate between the vessels with high absorbent capacity, distinctive of the mucous and submucous network and vessels with lymph flow and conduction function (precollectors, pre- and postlymph noda…

Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users

2020

Purpose: To evaluate skin biocompatibility of a nighttime hydrating eyelid gel and possible ocular surface effects in contact lens users (CLU) and non-contact lens users (NCLU). The formulation is registered as a medical device as Tridocosahexaenoine-AOX® (TDHA-AOX) (a concentrated DHA triglyceride), containing also hyaluronic acid (HA). Methods: A prospective, randomized, masked clinical trial was performed with 62 participants of both sexes, aged 20–70 years, split into: (1) CLU (n = 30) and (2) NCLU (n = 32). All participants were instructed to apply a single dose of the moisturizing gel (containing TDHA-AOX and HA) nightly to the upper and inner eyelids of their right eye (RE) only, and…

Egg consumption and human health: an umbrella review of observational studies

2019

Egg consumption has been an area of controversy regarding its impact on human health largely due to the content in cholesterol and its potential role in cardio-metabolic outcomes. This study aimed to summarise the level of evidence of egg consumption on various health outcomes. A systematic search for meta-analyses was performed: study design, dose-response relationship, heterogeneity and agreement of results over time, and identification of potential confounding factors were considered to assess the level of evidence. Results from this umbrella review showed a substantial no association between egg consumption and a number of health outcomes, including cancer, cardiovascular and metabolic …

DISEGNO IN ITINERE. DINAMICHE DI RICERCA ALL'INTERNO DI UNA SCUOLA

2008

Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide

2006

Background and purpose: 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are frequently used lipid-lowering drugs. Moreover, they exert pleiotropic effects on cellular stress responses and death. Here, we analysed whether lovastatin affects the sensitivity of primary human endothelial cells (HUVEC) to the anticancer drug doxorubicin. Experimental approach: We investigated whether pretreatment of HUVEC with low dose of lovastatin influences the cellular sensitivity to doxorubicin. To this end, cell viability, proliferation and apoptosis as well as DNA damage-triggered stress response were analysed. Key results: Lovastatin reduced the cytotoxic potency of doxorub…