Search results for "DPs"
showing 10 items of 17 documents
A conceptual framework for the integral management of marine protected areas
2009
A general conceptual framework for the management of marine protected areas (MPAs) was developed. The driver-pressure-state-impacts-response (DPSIR) framework was used to determine the elements affecting MPAs. The developed evaluation framework helped to select an appropriate suite of indicators to support an ecosystem approach, an assessment of the MPAs functioning and policy decisions. Gaps derived from the management and policy responses in the MPAs were also outlined. It was concluded that the DPSIR framework can help to simplify the complexity of MPA management. This document is a tool for policy makers, scientists and general public on the relevance of indicators to monitor changes an…
Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
2017
Human dental pulp stem cells (hDPSCs) are a source for cell therapy. Before implantation, an in vitro expansion step is necessary, with the inconvenience that hDPSCs undergo senescence following a certain number of passages, loosing their stemness properties. Long-term in vitro culture of hDPSCs at 21% (ambient oxygen tension) compared with 3–6% oxygen tension (physiological oxygen tension) caused an oxidative stress-related premature senescence, as evidenced by increased β-galactosidase activity and increased lysil oxidase expression, which is mediated by p16INK4a pathway. Furthermore, hDPSCs cultured at 21% oxygen tension underwent a downregulation of OCT4, SOX2, KLF4 and c-MYC factors, w…
BiLingva redaktora adaptācija DPS 3.0 dzinim
2015
Biznesа mоdelēšаnа tiek plаši izmаntоtа prоgrаmmаtūrаs izstrādes prоcesоs un ļоti bieži, izstrādājоt kādu biznesа prоcesа mоdeli, vаr sаskаrties аr tо, kа vаlоdаs rīki nаv piemērоti, lаi аttēlоtu biznesа prоcesа mоdeli tieši tā, kā ir pаredzēts. Šī dаrbа ietvаrоs tikа izveidоts BiLingvа 3.0 vаlоdаs redаktоrs аr TDА Frаmewоrk pаlīdzību, lаi tаjā uzbūvētie mоdeļi būtu sаvietоjаmi аr infоrmācijаs sistēmu un precīzi аprаkstītu visus tās nоtikumus. Dаrbā tikа аprаkstītа BiLingvа vаlоdаs specifikācijа, tās pielietоšаnа, аpskаtītаs TDА Frаmewоrk iespējаs, identificētаs prоblēmаs un izveidоts redаktоrs, kаs nоdrоšinа sаskаrni аr DPS. Rezultātā аrī tikа veikti nepieciešаmie pаpildinājumi un pievienо…
Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A
2022
The vast diversity of protein phosphatase 2A (PP2A) holoenzyme composition ensures its multifaceted role in the regulation of cellular growth and signal transduction. In several pathological conditions, such as cancer, PP2A is inhibited by endogenous inhibitor proteins. Several PP2A inhibitor proteins have been identified, one of which is α-endosulfine (ENSA). ENSA inhibits PP2A activity when it is phosphorylated at Ser67 by Greatwall (Gwl) kinase. The role of ENSA in PP2A inhibition is rather well characterized, but knowledge of the mechanism of inhibition is scarce. In this study, we have performed comprehensive structural characterization of ENSA, and its interaction with PP2A A- and var…
Mobbing, Bullying und andere Aggressionen unter Schülern als Quelle von Schulstress: Inwieweit sind die "Opfer" daran beteiligt?
2008
Schulstress kommt in erheblichem Maße auch durch aggressive Interaktionen zwischen Schülern zustande. Aggressionen in der Schule können vielfältige Formen annehmen und verschiedene Ursachen haben. In diesem Beitrag geht es um Bullying, Mobbing und relationale Aggression unter Schülern. Wichtige Forschungsbefunde zu den verschiedenen Aggressionsformen werden dargestellt. Anschließend wird eine psychoanalytische Behandlung einer Jugendlichen wegen Mobbing vorgestellt. Die Therapie erstreckte sich über 70 Stunden und umfasste auch begleitende Elterngespräche. Der Behandlungsverlauf verdeutlicht, dass es wichtig ist, die eigene Beteiligung der Schülerinnen und Schüler am Auslösen und Aufrechter…
First-principles LCAO study of the low and room temperature phases of CdPS$_3$
2020
A.K. is grateful to the Latvian Council of Science project no. lzp-2018/2-0353 for financial support. Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2.
Application of DPSIR framework to analyze the groundwater pollution threats of municipal solid waste: Case study Médiouna Landfill, Morocco
2021
This study addresses the issue of groundwater resources quality affected by solid waste disposed of in the Médiouna dumping site. In this order, we applied the Driving forcePressureStateImpact Response model (DPSIR) model combined with external factors of SWOT analysis (Opportunities and Threats) to assess the environmental impact of waste from Médiouna landfill on groundwater. The analysis study revealed that the continuous demographic expansion and economic growth made solid waste a complex problem. The study highlights the urgent need for implementing new strategies and redesigning more effective, operational and realizable management projects to rehabilitate the Médiouna landfill. In ad…
In vitro and in vivo investigations of osteogenic differentiation ability of dental pulp stem cells (DPSCs) and gingival mesenchymal stem cells (GMSC…
2020
Thanks to the use of human mesenchymal stem cells (hMSCs), smart biomaterials and active biomolecules, Regenerative Medicine (RM) and Bone Tissue Engineering (BTE) can restore structure and function of injured tissues. Among the different sources of hMSCs, the oro-facial hMSCs have promising in vitro and in vivo regeneration potential; in particular, dental pulp and gingiva are valuable sources of autologous hMSCs. The aim of this PhD thesis is testing the in vitro and in vivo bone regeneration ability of hMSCs isolated from dental pulp and inflamed gingiva of periodontally-compromised teeth, up to now considered biological waste tissues and discarded during surgical procedures, on two comm…
Alginate-Agarose Hydrogels Improve the In Vitro Differentiation of Human Dental Pulp Stem Cells in Chondrocytes. A Histological Study
2021
[EN] Matrix-assisted autologous chondrocyte implantation (MACI) has shown promising results for cartilage repair, combining cultured chondrocytes and hydrogels, including alginate. The ability of chondrocytes for MACI is limited by different factors including donor site morbidity, dedifferentiation, limited lifespan or poor proliferation in vitro. Mesenchymal stem cells could represent an alternative for cartilage regeneration. In this study, we propose a MACI scaffold consisting of a mixed alginate-agarose hydrogel in combination with human dental pulp stem cells (hDPSCs), suitable for cartilage regeneration. Scaffolds were characterized according to their rheological properties, and their…
La valorizzazione dell’agoralimentare di qualità e lo sviluppo del territorio
2012
Obiettivo dello studio è indagare la capacità di valorizzazione del patrimonio territoriale in alcuni ambienti della Sicilia (ricadenti nelle province Trapani) posti a confronto con un contesto di riferimento, individuato in Toscana (nella provincia di Siena). Questo studio ha indagato entrambe le aree attraverso due approcci complementari: la relazione tra le attività agricole e l’ambiente – con l’applicazione del DPSIR (Driving forces, Pressures, States, Impacts, Responses; Trisorio, 2004) – e il sistema relazionale degli operatori dei comprensori attraverso la SNA (Social Network Analysis). Si sono pertanto indagati gli aspetti relazionali del sistema produttivo del vino Alcamo DOC e del…