Search results for "DROSOPHILA"
showing 2 items of 782 documents
First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior
2022
Source data of the paper Ketkar, Gür, Molina-Obando et al. 2022, eLife. We analyzed the behavioral contribution and physiological response properties of first order interneurons L1, L2 and L3 in the Drosophila melanogaster visual system. Data are sorted by figures and comprise either behavioral measurements of flies walking on an air-cushioned ball while being shown visual stimuli, or in vivo two photon microscopy recordings of L1-L3 calcium responses. Please find all relevant information to use the data in the README file. The code to analyze the data, either written in Matlab or Python, is found at https://github.com/silieslab/Ketkar-Gur-MolinaObando-etal2022
(A,B) In vivo GCaMP6f signals recorded in layers M1, M5 and M9/10 of Mi1 (A) and Tm3 (B) neurons, before (blue, green) and after (gray, red) applicat…
2019
Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specifi…