Search results for "DUSP"

showing 4 items of 4 documents

Mācību materiāli matemātikas tematam "Virknes" 8.klasei interneta vidē "eduspace.lv

2015

Apbrīnojami, ka 59 miljoni skolotāju visā pasaulē strādā izolācijā un visbiežāk klasēs ar krīta tāfelēm – tā, it kā internets vispār neeksistētu.[18] Bakalaura darba mērķis ir izstrādāt mācību materiālus matemātikas tematam “Virknes 8.klasei interneta vidē “eduspace.lv”. Noskaidrot skolēnu attieksmi pret mācību materiāliem eduspace.lv. Izstrādāt metodisko materiālu eduspace.lv mācību materiālu veidošanai. Bakalaura darbs sastāv no ievada, četrām nodaļām, secinājumiem un 8 pielikumiem. Atslēgas vārdi: eduspace.lv lietošana mācību procesā, eduspace.lv. IT lietošana mācību procesā. Bakalaura darbā tiek analizēta literatūra par IT nozīmi mūsdienu mācību procesā. Bakalaura darbā tiek aplūkotas m…

Mācību materiāli eduspace.lveduspace.lv tematsPedagoģijaIT lietošana mācību procesāeduspace.lv lietošana mācību procesāeduspace.lv
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Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery.

2014

AbstractNucleotides activating P2Y13 receptors display neuroprotective actions against different apoptotic stimuli in cerebellar granule neurons. In the present study, P2Y13 neuroprotection was analyzed in conditions of genotoxic stress. Exposure to cisplatin and UV radiation induced caspase-3-dependent apoptotic cell death, and p38 MAPK signaling de-regulation. Pre-treatment with P2Y13 nucleotide agonist, 2methyl-thio-ADP (2MeSADP), restored granule neuron survival and prevented p38 long-lasting activation induced by cytotoxic treatments. Microarray gene expression analysis in 2MeSADP-stimulated cells revealed over-representation of genes related to protein phosphatase activity. Among them…

MAPK/ERK pathwayAgonistmedicine.drug_classMAP Kinase Signaling SystemUltraviolet Raysp38 mitogen-activated protein kinasesDUSPp38Genotoxic StressCREBNeuroprotectionMAPK protein phosphataseModels Biologicalp38 Mitogen-Activated Protein KinasesNucleotide receptorP2Y13 receptorCa2+/calmodulin-dependent protein kinaseCerebellummedicineAnimalsPhosphorylationRats WistarReceptorMolecular BiologyCell NucleusNeuronsbiologyCell DeathCaspase 3Receptors Purinergic P2Dual Specificity Phosphatase 2Cell BiologyThionucleotidesNeuroprotectionCell biologyRatsAdenosine DiphosphateEnzyme ActivationNeuroprotective AgentsCytoprotectionbiology.proteinCisplatinDNA DamageBiochimica et biophysica acta
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Aleksandrijas Klementa logosa teoloģija platonisma tradīcijas kontekstā

2019

Darba nosaukums ir “Aleksandrijas Klementa logosa teoloģija platonisma tradīcijas kontekstā.” Šis darbs ir pētījums par Aleksandrijas Klementa logosa teoloģijas izcelsmi un tās iederību platonisma tradīcijā. Darba gaitā autore analizē Platona priekštatu par pilnībā transcendentu un cilvēkam nepieejamu augstāko būtni, šīs idejas attīstību tālākā platonisma tradīcijā un veidu, kādā tā pati ideja ir tikusi transformēta agrīnajā kristietībā, konkrētāk – Aleksandrijas Klementa teoloģijā. Pētījuma trīs daļās tiek analizēti, pirmkārt, darba tēmai aktuālie Platona dialogu fragmenti un Platona dievišķās hierarhijas izpratne, otrkārt, vidusplatonistu un hellenizētā jūdaisma filozofijas skolas pārstāv…

vidusplatonismsPlatonsTeoloģija un reliģiju zinātneAleksandrijas Klementslogossplatonisms
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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