Search results for "DamID"
showing 10 items of 73 documents
Neurobiology of cannabinoid receptor signaling .
2020
The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous system. Despite its widespread localization, its functions within the context of distinct neural processes are very well discernable and specific. This is remarkable, and the question remains as to how such specificity is achieved. One key player in the ECS is the cannabinoid type 1 receptor (CBEl sistema endocannabinoide (SEC) apareció como un sistema de señalización muy versátil en el sistema nervioso. A pesar de su existencia amplia y ubicua, sus funciones están integradas en el contexto de distintos procesos neuronales y, en última instancia, son bastante bien discernibles y específicas. Esto es n…
The endocannabinoid system: emotion, learning and addiction
2008
The identification of the cannabinoid receptor type 1 (CB1 receptor) was the milestone discovery in the elucidation of the behavioural and emotional responses induced by the Cannabis sativa constituent Delta(9)-tetrahydrocannabinol. The subsequent years have established the existence of the endocannabinoid system. The early view relating this system to emotional responses is reflected by the fact that N-arachidonoyl ethanolamine, the pioneer endocannabinoid, was named anandamide after the Sanskrit word 'ananda', meaning 'bliss'. However, the emotional responses to cannabinoids are not always pleasant and delightful. Rather, anxiety and panic may also occur after activation of CB1 receptors.…
Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors
2001
The effects of anandamide on [3H]-acetylcholine release and muscle contraction were studied on the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum preincubated with [3H]-choline. Anandamide increased both basal [3H]-acetylcholine release (pEC50 6.3) and muscle tone (pEC50 6.3). The concentration-response curves for anandamide were shifted to the right by 1 μM capsazepine (pKB 7.5 and 7.6), and by the combined blockade of NK1 and NK3 tachykinin receptors with the antagonists CP99994 plus SR142801 (each 0.1 μM). The CB1 and CB2 receptor antagonists, SR141716A (1 μM) and SR144528 (30 nM), did not modify the facilitatory effects of anandamide. Anandamide inhibited the e…
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice
2012
Background and purpose Gastrointestinal (GI) motility is regulated in part by fatty acid ethanolamides (FAEs), including the endocannabinoid (EC) anandamide (AEA). The actions of FAEs are terminated by fatty acid amide hydrolase (FAAH). We investigated the actions of the novel FAAH inhibitor AM3506 on normal and enhanced GI motility. Experimental approach We examined the effect of AM3506 on electrically-evoked contractility in vitro and GI transit and colonic faecal output in vivo, in normal and FAAH-deficient mice treated with saline or LPS (100 µg·kg(-1), i.p.), in the presence and absence of cannabinoid (CB) receptor antagonists. mRNA expression was measured by quantitative real time-PCR…
TRPV1 channels in nitric oxide-mediated signalling: insight on excitatory transmission in rat CA1 pyramidal neurons
2022
Nitric oxide (NO) is a fascinating signalling molecule implicated in a plethora of biological functions, especially at the synaptic level. Exploring neurotransmission in the hippocampus could be instrumental in the individuation of putative targets for nitric-oxide mediated neuromodulation, especially in terms of the potential repercussions on fundamental processes i.e. synaptic plasticity and excitability-related phenomena. Among these targets, endovanilloid signalling constitutes an object of study since Transient Receptors Vanilloid type 1 (TRPV1) channels possess a NO-sensitive gate modulating its activation. Also, NO has been referred to as a mediator for numerous endocannabinoid effec…
CCDC 986954: Experimental Crystal Structure Determination
2014
Related Article: Ivan I. Eliseev, Pavel V. Gushchin, Yi-An Chen, Pi-Tai Chou, Matti Haukka, Galina L. Starova, Vadim Yu. Kukushkin|2014|Eur.J.Inorg.Chem.||4101|doi:10.1002/ejic.201402364
CCDC 986955: Experimental Crystal Structure Determination
2014
Related Article: Ivan I. Eliseev, Pavel V. Gushchin, Yi-An Chen, Pi-Tai Chou, Matti Haukka, Galina L. Starova, Vadim Yu. Kukushkin|2014|Eur.J.Inorg.Chem.||4101|doi:10.1002/ejic.201402364
CCDC 966546: Experimental Crystal Structure Determination
2013
Related Article: Dmitrii S. Bolotin, Nadezhda A. Bokach, Andreii S. Kritchenkov, Matti Haukka, Vadim Yu. Kukushkin|2013|Inorg.Chem.|52|6378|doi:10.1021/ic4000878
CCDC 986953: Experimental Crystal Structure Determination
2014
Related Article: Ivan I. Eliseev, Pavel V. Gushchin, Yi-An Chen, Pi-Tai Chou, Matti Haukka, Galina L. Starova, Vadim Yu. Kukushkin|2014|Eur.J.Inorg.Chem.||4101|doi:10.1002/ejic.201402364
CCDC 2060891: Experimental Crystal Structure Determination
2021
Related Article: Lucija Ptiček, Lucija Hok, Petra Grbčić, Filip Topić, Mario Cetina, Kari Rissanen, Sandra Kraljević Pavelić, Robert Vianello, Livio Racané|2021|Org.Biomol.Chem.|19|2784|doi:10.1039/D1OB00235J