Search results for "Database"
showing 10 items of 2136 documents
Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database
2012
Background. Physical activity and occupational exposures appeared to play a relevant role in pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknown origin. Materials and methods. We aimed to make an overview of the clinical characteristics and life - style (occupation and sport) of a population of 395 patients with ALS from campania, in southern Italy. Results. ALS onset resulted anticipated of about 11 years in industry workers, whilst the more frequent site of onset among farmers was upper limbs. compared to non-athletes, athletes, particu- larly soccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years. Discussion…
Pan-cancer analysis of whole genomes
2020
Publisher's version (útgefin grein)
Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors
2007
Mammalian G protein-coupled receptor (GPCR) genes are characterised by a large proportion of intronless genes or a lower density of introns when compared with GPCRs of invertebrates. It is unclear which mechanisms have influenced intron density in this protein family, which is one of the largest in the mammalian genomes. We used a combination of Hidden Markov Models (HMM) and BLAST searches to establish the comprehensive repertoire of Rhodopsin GPCRs from seven species and performed overall alignments and phylogenetic analysis using the maximum parsimony method for over 1400 receptors in 12 subgroups. We identified 14 different Ancestral Receptor Groups (ARGs) that have members in both vert…
CASE tool support for co-operative work in information systems design
1998
The need for asynchronous co-operative work in design is shown by many surveys of CASE tool use and research on design. MetaEdit+ is a metaCASE environment that allows multiple simultaneous modellers to work together on designing information systems and also information systems design methods. We describe the automatic locking strategies that enable MetaEdit+ to offer a high level of concurrency whilst guaranteeing consistency, enabling effective co-operative work. In particular we describe a new collection data structure that allows high concurrency of updates even at small sizes, fulfilling the need in CASE for largest growth of design information at the start of a project. Finally, we ev…
Transparent Model for State Management
2013
To ensure optimum governance of the state (regions, sectors, specific activities) all management system units (tasks, functions and services, normative environment, institutional framework, budget funding) have to operate in strong cooperation and consistency, which should be defined by corresponding documents. Unfortunately this logical relevance does not always exist. Documents and information are weakly connected, because of the huge complexity of units that objectively hinders implementation of the strong linkage and seriously weakens management quality. The situation can be radically improved by usage of ontological methodology for development of the back-office of the management syste…
Semantic infrastructure system with feedback: Application on traffic
2012
The Semantic Web is a powerful approach used by some intelligent applications to manage complex information in many different fields. Nevertheless, there are not standard tools to design and built the applications, therefore each problem need to be analysed separately in order to meet the requirements. In this paper is presented an overview of a system based on a semantic approach with the goal of managing real-time information. The paper studies the application of this system on ITS (Intelligent Transport Systems) as an example of a typical real-time information system. The system gathers real information from the users and the environment, making intelligent decisions and delivering real-…
Semi-strong efficiency of Bitcoin
2018
Abstract This research examines the semi-strong efficiency of Bitcoin in the Bitstamp and Mt.Gox markets, showing how the digital currency responds to monetary policy and Bitcoin events. On the one hand, we observe that Bitcoin has become more efficient over time in relation to its own events. On the other hand, Bitcoin is not affected by monetary policy news, highlighting the absence of any kind of control on Bitcoin. These findings are relevant for investors and policymakers since Bitcoin is a financial asset without any connection to the measures of central banks.
Transaction management for m-commerce at a mobile terminal
2006
Although there has been a lot of discussion of "transactions" in mobile e-commerce (m-commerce), very little attention has been paid for distributed transactional properties of the computations facilitating m-commerce. In this paper, we first present a requirement analysis and then present a wireless terminal-based transaction manager (TM) architecture. This architecture is based on the assumption that there is an application that supports certain business transaction(s) and that it uses the TM to store transactional state information and retrieve it after a communication link, application, or terminal crash. We present the design of such a TM, including the application interface, modules a…
Determinants of silent and explicit industrial design
2018
This paper investigates the relationship between the use of silent or explicit design (SD or ED) and the characteristics of firms or sectors that use each of these types of design in Argentina. The findings show that SD differs from ED and that the differences have important implications for the creation of policies to support competitiveness as well as for the development of business strategies. The study contributes to the literature by identifying three groups of dimensions. (1) Structural. Neither size nor barriers to the use of design bear relation to the use of design. (2) Dynamic. SD and ED have different effects on competitiveness based on the different links each type of design has…
Spatial mapping of price competition using logit-type market share models and store-level scanner-data
2009
This paper proposes a methodology to obtain reliable spatial maps of price competition using store-level scanner data. Specifically, a procedure to obtain a symmetric matrix of similarities between brands considering their substitutability depending on price variations is proposed. The matrix is derived from a market response model where price cross-effects are split into two components. The first component accounts for the fact that price variation in one brand can have different effects to price variation in other brands (ie j → j′≠j′ → j). The second component accounts for the fact that the price of each brand can have different effects across competing brands (ie j → j′≠j → j ″). The ma…