Search results for "Decidua"
showing 6 items of 26 documents
Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium.
2008
This study was prompted by the observation that decidual endothelial cells (DECs), unlike endothelial cells (ECs) of blood vessels in normal skin, kidney glomeruli and brain, express surface-bound C1q in physiologic pregnancy. This finding was unexpected, because deposits of C1q are usually observed in pathologic conditions and are associated with complement activation. In the case of DECs, we failed to detect immunoglobulins and C4 co-localized with C1q on the cell surface. Surprisingly, DECs expressed mRNA for the three chains of C1q and secreted detectable level of this component in serum-free medium. The ability to synthesize C1q is acquired by DECs during pregnancy and is not shared by…
An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development.
2010
Abstract Fetal trophoblast cells invading the decidua in the early phase of pregnancy establish complex interaction with the maternal extracellular matrix. We discovered that C1q was widely distributed in human decidual stroma in the absence of C4 and C3 and was actively synthesized by migrating extravillous trophoblasts. The cells expressed the messages for the three chains of C1q and secreted this complement component that interacted with the proteins of the decidual extracellular matrix. Solid phase-bound C1q promoted trophoblast adhesion and migration, and cell binding to C1q resulted in activation of ERK1/2 MAPKs. Ab inhibition experiments showed that the receptors for the globular hea…
Eiropas lapegles (Larix decidua) radiālā pieauguma saistība ar meteoroloģiskajiem faktoriem Latvijā.
2021
Klimata izmaiņu ietekmē, mainoties vides apstākļiem mežā, mainas koku sugu sastāvs. Lai nodrošinātu kvalitatīvās un kvantitatīvās prasības koksnes ražošanā, nākotnē var paredzēt meža apsaimniekošanu, izmantojot introducētu koku sugu audzēšanu, piemēram, Eiropas lapegli. Tam nepieciešams novērtēt faktorus, kas limitē konkrētas koku sugas augšanu un koksnes pieaugumu. Lai noskaidrotu, kuri ir limitējošie meteoroloģiskie faktori, kas ietekmē Eiropas lapegles ikgadējo radiālo papildpieaugumu, veikta paraugu ieguve desmit Eiropas lapegļu mežaudzēs Latvijā, iegūto paraugu datu apstrāde un analīze. Iegūtie lapegļu gadskārtas paraugi šķērsdatēti, iegūstot katras mežaudzes hronoloģiju. Lai raksturot…
Molecular investigation on the etiology of preeclampsia and new strategies for its early diagnosis
2023
Endometrial decidualization is critical for pregnancy establishment and maintenance. This process promotes endometrial remodeling allowing placental cytotrophoblasts (CTBs) invasion up to an appropriate depth to form the maternal-fetal interface. A shallow CTBs invasion compromises healthy pregnancy and it is associated with the development of severe preeclampsia (sPE). Our working hypothesis is that defective decidualization impairs the adaptation of the maternal “soil” ─the decidua─ to be invaded by CTBs and plays a pivotal role in the etiology of sPE. Previously, we have demonstrated the existence of an in vitro defective decidualization of endometrial stromal cells isolated from women w…
Decidualización defectuosa durante y después de un embarazo con preeclampsia revela una contribución materna en la etiología de la enfermedad
2020
La Preeclampsia (PE) es una enfermedad obstétrica caracterizada por hipertensión arterial en gestante previamente normotensa a partir de la semana 20 de gestación con o sin síntomas asociados y con importante morbimortalidad materno-fetal y neonatal asociada. La única cura actual es el alumbramiento. La etiología es desconocida pero hay una decidualización endometrial alterada y una invasión trofoblástica superficial involucrada que produce placentación anómala y desencadena el fenotipo clínico característico. Estudios recientes in vitro demuestran alteración en la expresión de genes involucrados en decidualización como anexina A2 (ANXA2). Esta proteína está presente en la mayoría de célula…
Using machine learning on tree-ring data to determine the geographical provenance of historical construction timbers
2023
Funder: Bavarian Climate Research Network (BayKliF)