Search results for "Defibrotide"
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Vascular atherosclerotic disease: Evaluation of white blood cell rheology and metabolism after acute intravenous administration of defibrotide
1994
Defibrotide is a single-strand polydeoxyribonucleotide, obtained by controlled depolymerization of DNA extracted from mammalian organs. It stimulates vascular prostacyclin production and secretion (1-3) and enhances fibrinolysis (1, 4-6). Several clinical trials have evidentiated that defibrotide is effective in the prophylaxis of deep vein thrombosis and in the treatment of peripheral obliterative arterial disease (for a review see ref. 7). There are several reports concerning, in vitro and in vivo, the dose-dependent activity of defibrotide on the polymorphonuclear leucocytes (PMN). From these results, the molecule influences the PMN adhesivity (8, 9) and especially PMN activation, with s…
Recurrent venous thromboembolism complicated by heparin-induced thrombocytopenia as a first manifestation of an occult cancer: a case report.
2008
Heparin-Induced Trombocytopenia (HIT) is a serious and potentially fatal complication of patients on heparins. Its management is difficult and it can be more complicated in patients with cancer because of the hemorrhagic risk carried out by direct inhibitor of thrombin, the currently approved drug for HIT. At present, it is not clear whether cancer patients also have an increased risk of HIT. We describe the case of a patient with occult cancer at the moment of the index venous thrombosis, who developed Deep Vein Thrombosis (DVT) and concomitant HIT with thrombotic complications (recurrent contralateral venous thrombosis). The management of HIT was efficaciously based on the combined use o…